Noninvasive Evaluation of Renal Allograft Fibrosis by MRI
MRI 无创评估同种异体移植肾纤维化
基本信息
- 批准号:9976272
- 负责人:
- 金额:$ 22.2万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-06-15 至 2022-03-31
- 项目状态:已结题
- 来源:
- 关键词:AgingAllograftingAnimal ModelAtrophicBenchmarkingBiological MarkersBiophysicsBiopsyBlood PressureChronicChronic Kidney FailureChronic rejection of renal transplantCicatrixClinicalComplexConsequentialismDataDepositionDeteriorationDevelopmentDisease ProgressionEarly DiagnosisEarly identificationEnd stage renal failureEvaluationEvolutionFamily suidaeFibrosisFrequenciesGraft SurvivalHealth Care CostsHealth ProfessionalHumanImageImaging TechniquesInjuryInjury to KidneyInterobserver VariabilityInterventionKidneyKidney TransplantationLightLiving DonorsMagnetic Resonance ImagingMapsMeasurementMeasuresMethodsModelingMonitorMorbidity - disease rateMusOutcomePathogenesisPathway interactionsPatient RecruitmentsPatientsPerfusionPhysiologic pulsePropertyProteinuriaProtocols documentationRelaxationRenal Blood FlowRenal Replacement TherapyRenal functionReproducibilitySamplingSampling ErrorsScanningSignal TransductionSpin LabelsStandardizationTechniquesTestingTherapeuticTissuesTransplant RecipientsTrichrome stainTubular formationWestern Worldaging populationbaseclinical applicationclinical translationcostgraft functionhemodynamicshuman subjectimaging modalityindexinginstrumentinterstitialkidney allograftkidney biopsykidney fibrosisliving kidney donormacromoleculemagnetic fieldmortalitynovelpost-transplantrenal ischemiasuccesstool
项目摘要
Renal fibrosis is a final pathway and important biomarker of injury common to aging and to most forms of
chronic kidney diseases (CKD). It is assessed primarily by renal biopsy, which is prohibitively invasive and is
limited by inadequate sampling. However, reliable strategies to detect renal fibrosis are yet to be identified.
These notions underscore the need for reliable noninvasive tools for early detection of kidney injury,
to enhance development and monitoring of therapeutic strategies.
CKD involves high morbidity and mortality and substantial healthcare cost, and might eventuate in end-
stage renal failure requiring renal replacement therapy. However, graft survival after kidney transplantation (KT)
is suboptimal, and deterioration in function and loss of allografts are often associated with interstitial fibrosis.
Monitoring the extent of fibrosis noninvasively could decrease the cost and potential complications associated
with repeated biopsies, and help direct and optimize management. KT recipients also undergo protocol
biopsies, which can serve as a reference and allow evaluation of techniques that aim to assess renal fibrosis.
Magnetization transfer imaging (MTI) magnetic resonance imaging (MRI) is a novel noninvasive method to
evaluate the tissue macromolecular composition. We have demonstrated that MTI can assess ischemic kidney
fibrosis in murine and swine models. However, the clinical utility of MT-MRI to assess renal fibrosis is currently
limited, because it is inherently semi-quantitative. In contrast, quantitative MT (qMT), based on biophysical
compartment models, provides more objective measurement of tissue MT properties. A model fitting of MR
signal acquired with various MT pulse amplitudes and offset frequencies, combined with scan-specific B0/B1/T1
maps, give rise to a more complete definition of tissue parameters, including a “bound pool fraction”, a direct
measure of the macromolecular content in tissue (an index of fibrosis).
The hypothesis underlying this proposal is that qMT reliably detects development of allograft fibrosis in
human subjects after KT. To test this hypothesis, we will correlate the qMT-derived bound pool fraction with
renal fibrosis as per biopsy in 20 patients 4 or 7 years after living donor KT. We will also compare the bound
pool fraction to renal blood flow, oxygenation, and function, and will test the ability of qMT to provide consistent
assessments of fibrosis at different magnetic field strengths. Two specific aims will test the hypotheses that:
Specific Aim 1: qMT provides reliable and consequential assessment of fibrosis in human kidney allografts.
Specific Aim 2: Renal fibrosis assessed by qMT in human kidney allografts is reproducible at 1.5 T and 3.0 T.
The proposed studies may therefore establish a reliable, noninvasive, and clinically feasible strategy to
quantify kidney fibrosis, a key biomarker for renal aging, disease progression, and outcomes.
肾纤维化是衰老和大多数形式的肾损伤的最终途径和重要的生物标志物
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Lilach O Lerman其他文献
Endothelium-dependent coronary microvascular dysfunction is associated with advanced coronary plaque characteristics in patients with nonobstructive coronary atherosclerosis
内皮依赖性冠状动脉微血管功能障碍与非阻塞性冠状动脉粥样硬化患者的晚期冠状动脉斑块特征相关
- DOI:
- 发表时间:
2019 - 期刊:
- 影响因子:0
- 作者:
Shigeo Godo;Michel T Corban;Takumi Toya;Rajiv Gulati;Lilach O Lerman;Amir Lerman - 通讯作者:
Amir Lerman
Coronary microvascular endothelial dysfunction is associated with advanced coronary plaque characteristics in patients with early coronary atherosclerosis
冠状动脉微血管内皮功能障碍与早期冠状动脉粥样硬化患者的晚期冠状动脉斑块特征相关
- DOI:
- 发表时间:
2019 - 期刊:
- 影响因子:0
- 作者:
Shigeo Godo;Michel T Corban;Takumi Toya;Rajiv Gulati;Lilach O Lerman;Amir Lerman - 通讯作者:
Amir Lerman
Coronary microvascular endothelial dysfunction is an independent predictor of larger epicardial plaque area and higher plaque burden
冠状动脉微血管内皮功能障碍是较大心外膜斑块面积和较高斑块负荷的独立预测因素
- DOI:
- 发表时间:
2018 - 期刊:
- 影响因子:0
- 作者:
Michel T Corban;Shigeo Godo;Rajiv Gulati;Lilach O Lerman;Amir Lerman - 通讯作者:
Amir Lerman
Coronary microvascular endothelial dysfunction is associated with plaque vulnerability in patients with early coronary atherosclerosis
早期冠状动脉粥样硬化患者冠状动脉微血管内皮功能障碍与斑块易损性相关
- DOI:
- 发表时间:
2018 - 期刊:
- 影响因子:0
- 作者:
Shigeo Godo;Michel T Corban;Rajiv Gulati;Lilach O Lerman;Amir Lerman - 通讯作者:
Amir Lerman
1027-189 Chronic endothelin receptor antagonism preserves endothelial function in a transgenic mouse model of alzheimer's disease
- DOI:
10.1016/s0735-1097(04)91902-x - 发表时间:
2004-03-03 - 期刊:
- 影响因子:
- 作者:
Ahmad A Elesber;Piero Bonetti;Joerg Herrmann;Julie Woodrum;Steven Younkin;Lilach O Lerman;Amir Lerman - 通讯作者:
Amir Lerman
Lilach O Lerman的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Lilach O Lerman', 18)}}的其他基金
Quantitative magnetization transfer MRI for evaluation of renal fibrosis
定量磁化转移 MRI 评估肾纤维化
- 批准号:
10337329 - 财政年份:2020
- 资助金额:
$ 22.2万 - 项目类别:
Quantitative magnetization transfer MRI for evaluation of renal fibrosis
定量磁化转移 MRI 评估肾纤维化
- 批准号:
10549318 - 财政年份:2020
- 资助金额:
$ 22.2万 - 项目类别:
Noninvasive Evaluation of Renal Allograft Fibrosis by MRI
MRI 无创评估同种异体移植肾纤维化
- 批准号:
10176331 - 财政年份:2020
- 资助金额:
$ 22.2万 - 项目类别:
Obesity-induced mesenchymal stem cell senescence
肥胖引起的间充质干细胞衰老
- 批准号:
10062968 - 财政年份:2018
- 资助金额:
$ 22.2万 - 项目类别:
Obesity-induced mesenchymal stem cell senescence
肥胖引起的间充质干细胞衰老
- 批准号:
10312008 - 财政年份:2018
- 资助金额:
$ 22.2万 - 项目类别:
MSC-derived microvesicles in metabolic syndrome and renovascular disease
间充质干细胞衍生的微泡在代谢综合征和肾血管疾病中的作用
- 批准号:
9231450 - 财政年份:2015
- 资助金额:
$ 22.2万 - 项目类别:
Hypoxia and inflammatory injury in human renovascular hypertension
人类肾血管性高血压的缺氧和炎症损伤
- 批准号:
8722682 - 财政年份:2014
- 资助金额:
$ 22.2万 - 项目类别:
Noninvasive assessment of renal fibrosis using magnetization transfer MRI
使用磁化转移 MRI 无创评估肾纤维化
- 批准号:
9352889 - 财政年份:2014
- 资助金额:
$ 22.2万 - 项目类别:
Low-Energy Shockwave Treatment Distal To Peripheral Vascular Disease
低能量冲击波治疗远端周围血管疾病
- 批准号:
8617434 - 财政年份:2014
- 资助金额:
$ 22.2万 - 项目类别:
Hypoxia and inflammatory injury in human renovascular hypertension
人类肾血管性高血压的缺氧和炎症损伤
- 批准号:
9049492 - 财政年份:2014
- 资助金额:
$ 22.2万 - 项目类别:
相似海外基金
Establishment of novel osteochondral allografting combined with growth factor- collagen-binding domain fusion technology
新型同种异体骨软骨移植联合生长因子-胶原蛋白结合域融合技术的建立
- 批准号:
26462277 - 财政年份:2014
- 资助金额:
$ 22.2万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Translating PTH Therapy as an Adjuvant for Structural Allografting
将 PTH 疗法转化为结构性同种异体移植的佐剂
- 批准号:
8344380 - 财政年份:2012
- 资助金额:
$ 22.2万 - 项目类别:
Composite Allografting for Promoting Survival of Corneal Transplants
复合同种异体移植促进角膜移植的存活
- 批准号:
7878675 - 财政年份:2009
- 资助金额:
$ 22.2万 - 项目类别:
Composite Allografting for Promoting Survival of Corneal Transplants
复合同种异体移植促进角膜移植的存活
- 批准号:
7677758 - 财政年份:2009
- 资助金额:
$ 22.2万 - 项目类别:
Augmenting Antitumor Immunity after Allografting
增强同种异体移植后的抗肿瘤免疫力
- 批准号:
7466112 - 财政年份:2008
- 资助金额:
$ 22.2万 - 项目类别:
Augmenting Antitumor Immunity after Allografting
增强同种异体移植后的抗肿瘤免疫力
- 批准号:
8010394 - 财政年份:2008
- 资助金额:
$ 22.2万 - 项目类别:
Augmenting Antitumor Immunity after Allografting
增强同种异体移植后的抗肿瘤免疫力
- 批准号:
8208131 - 财政年份:2008
- 资助金额:
$ 22.2万 - 项目类别:
Augmenting Antitumor Immunity after Allografting
增强同种异体移植后的抗肿瘤免疫力
- 批准号:
7575273 - 财政年份:2008
- 资助金额:
$ 22.2万 - 项目类别:
Augmenting Antitumor Immunity after Allografting
增强同种异体移植后的抗肿瘤免疫力
- 批准号:
7765518 - 财政年份:2008
- 资助金额:
$ 22.2万 - 项目类别:














{{item.name}}会员




