Quantitative magnetization transfer MRI for evaluation of renal fibrosis
定量磁化转移 MRI 评估肾纤维化
基本信息
- 批准号:10337329
- 负责人:
- 金额:$ 52.83万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-03-15 至 2024-01-31
- 项目状态:已结题
- 来源:
- 关键词:AcuteAngioplastyAnimal ModelBenchmarkingBiological MarkersBiophysicsCardiovascular systemChronic Kidney FailureClinicalComplexDataDevelopmentDisease ProgressionDistalEarly identificationEnd stage renal failureEvaluationEvolutionFamily suidaeFibrosisFrequenciesHealth Care CostsHealth ProfessionalHistologyHumanHypertensionImageImage AnalysisImaging TechniquesInjuryInjury to KidneyInterobserver VariabilityInterventionKidneyKidney DiseasesMagnetic Resonance ImagingMapsMeasurementMeasuresMethodsModelingMorbidity - disease rateOutcomePathogenesisPathway interactionsPatientsPerfusionPhysiologic pulsePilot ProjectsProgressive DiseasePropertyProtocols documentationRecoveryReference StandardsRelaxationRenal Replacement TherapyRenal TissueRenal Vascular DisorderRenal functionReproducibilityRisk FactorsSampling ErrorsScanningSecondary toSignal TransductionStandardizationStentsStructureTestingTherapeuticTissuesWestern Worldaging populationbaseblood pressure controlclinical applicationclinical translationdetectorfunctional improvementfunctional restorationhemodynamicshuman subjectimaging modalityinnovationinstrumentkidney biopsykidney dysfunctionkidney fibrosismortalitymouse modelnephrogenesisnon-invasive imagingnovelporcine modelrenal arteryrenal ischemiaresponsesuccesstissue biomarkers
项目摘要
Renal fibrosis is a final pathway and important biomarker of injury common to most forms of kidney disease.
For example, in renal vascular disease (RVD) progressive renal fibrosis may induce kidney injury and
hypertension. Early identification of fibrosis and adequate intervention may slow down renal disease
progression, but adequate noninvasive strategies to detect and quantify renal fibrosis are yet to be identified.
Magnetization transfer imaging (MTI) magnetic resonance imaging (MRI) is a novel noninvasive method to
evaluate the tissue macromolecular composition. We have demonstrated that MTI can assess stenotic kidney
fibrosis in murine and swine models of unilateral RVD. However, the clinical utility of MT-MRI to assess renal
fibrosis is currently limited, because it is inherently semi-quantitative. In contrast, quantitative MT (qMT), based
on biophysical compartment models, provides more objective measurement of tissue MT properties. A model
fitting of MR signal acquired with various MT pulse amplitudes and offset frequencies, combined with scan-
specific B0/B1/T1 maps, give rise to a more complete definition of tissue parameters, including a “bound pool
fraction”, a direct measure of the macromolecular content in tissue.
The hypothesis underlying this proposal is that qMT would reliably detect development of renal fibrosis
at both 1.5T and 3.0T in subjects with RVD. To test this hypothesis, which is supported by strong preliminary
data, we will initially develop, optimize, and validate qMT for evaluation of fibrosis in the post-stenotic swine
kidney. We will correlate qMT-derived renal fibrosis with reference standards, as well as with single-kidney
hemodynamics, function, and oxygenation, quantified using cutting-edge multi-detector CT (MDCT) and MRI
techniques. We will then determine the ability of qMT to predict renal recovery in pigs with RVD undergoing
revascularization. Further, we will perform a pilot study to test the ability of qMT to quantify fibrosis in the post-
stenotic human kidney, in comparison to innovative biomarkers of renal dysfunction and tissue damage.
Three specific aims will test the hypotheses: Specific Aim 1: qMT in stenotic swine kidneys is feasible,
reliable, and reproducible at 1.5 and 3.0 T. Specific Aim 2: qMT predicts renal recovery potential in response
to PTRA. Specific Aim 3: qMT in stenotic human kidneys is feasible, reproducible, and predicts recovery.
The proposed studies may therefore establish a reliable, noninvasive, and clinically feasible strategy to
quantify kidney fibrosis, a key biomarker for renal outcomes and therapeutic success.
肾纤维化是大多数肾脏疾病常见的最终损伤途径和重要的生物标志物。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Lilach O Lerman其他文献
Endothelium-dependent coronary microvascular dysfunction is associated with advanced coronary plaque characteristics in patients with nonobstructive coronary atherosclerosis
内皮依赖性冠状动脉微血管功能障碍与非阻塞性冠状动脉粥样硬化患者的晚期冠状动脉斑块特征相关
- DOI:
- 发表时间:
2019 - 期刊:
- 影响因子:0
- 作者:
Shigeo Godo;Michel T Corban;Takumi Toya;Rajiv Gulati;Lilach O Lerman;Amir Lerman - 通讯作者:
Amir Lerman
Coronary microvascular endothelial dysfunction is associated with advanced coronary plaque characteristics in patients with early coronary atherosclerosis
冠状动脉微血管内皮功能障碍与早期冠状动脉粥样硬化患者的晚期冠状动脉斑块特征相关
- DOI:
- 发表时间:
2019 - 期刊:
- 影响因子:0
- 作者:
Shigeo Godo;Michel T Corban;Takumi Toya;Rajiv Gulati;Lilach O Lerman;Amir Lerman - 通讯作者:
Amir Lerman
Coronary microvascular endothelial dysfunction is an independent predictor of larger epicardial plaque area and higher plaque burden
冠状动脉微血管内皮功能障碍是较大心外膜斑块面积和较高斑块负荷的独立预测因素
- DOI:
- 发表时间:
2018 - 期刊:
- 影响因子:0
- 作者:
Michel T Corban;Shigeo Godo;Rajiv Gulati;Lilach O Lerman;Amir Lerman - 通讯作者:
Amir Lerman
Coronary microvascular endothelial dysfunction is associated with plaque vulnerability in patients with early coronary atherosclerosis
早期冠状动脉粥样硬化患者冠状动脉微血管内皮功能障碍与斑块易损性相关
- DOI:
- 发表时间:
2018 - 期刊:
- 影响因子:0
- 作者:
Shigeo Godo;Michel T Corban;Rajiv Gulati;Lilach O Lerman;Amir Lerman - 通讯作者:
Amir Lerman
1027-189 Chronic endothelin receptor antagonism preserves endothelial function in a transgenic mouse model of alzheimer's disease
- DOI:
10.1016/s0735-1097(04)91902-x - 发表时间:
2004-03-03 - 期刊:
- 影响因子:
- 作者:
Ahmad A Elesber;Piero Bonetti;Joerg Herrmann;Julie Woodrum;Steven Younkin;Lilach O Lerman;Amir Lerman - 通讯作者:
Amir Lerman
Lilach O Lerman的其他文献
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{{ truncateString('Lilach O Lerman', 18)}}的其他基金
Noninvasive Evaluation of Renal Allograft Fibrosis by MRI
MRI 无创评估同种异体移植肾纤维化
- 批准号:
9976272 - 财政年份:2020
- 资助金额:
$ 52.83万 - 项目类别:
Quantitative magnetization transfer MRI for evaluation of renal fibrosis
定量磁化转移 MRI 评估肾纤维化
- 批准号:
10549318 - 财政年份:2020
- 资助金额:
$ 52.83万 - 项目类别:
Noninvasive Evaluation of Renal Allograft Fibrosis by MRI
MRI 无创评估同种异体移植肾纤维化
- 批准号:
10176331 - 财政年份:2020
- 资助金额:
$ 52.83万 - 项目类别:
Obesity-induced mesenchymal stem cell senescence
肥胖引起的间充质干细胞衰老
- 批准号:
10062968 - 财政年份:2018
- 资助金额:
$ 52.83万 - 项目类别:
Obesity-induced mesenchymal stem cell senescence
肥胖引起的间充质干细胞衰老
- 批准号:
10312008 - 财政年份:2018
- 资助金额:
$ 52.83万 - 项目类别:
MSC-derived microvesicles in metabolic syndrome and renovascular disease
间充质干细胞衍生的微泡在代谢综合征和肾血管疾病中的作用
- 批准号:
9231450 - 财政年份:2015
- 资助金额:
$ 52.83万 - 项目类别:
Hypoxia and inflammatory injury in human renovascular hypertension
人类肾血管性高血压的缺氧和炎症损伤
- 批准号:
8722682 - 财政年份:2014
- 资助金额:
$ 52.83万 - 项目类别:
Noninvasive assessment of renal fibrosis using magnetization transfer MRI
使用磁化转移 MRI 无创评估肾纤维化
- 批准号:
9352889 - 财政年份:2014
- 资助金额:
$ 52.83万 - 项目类别:
Low-Energy Shockwave Treatment Distal To Peripheral Vascular Disease
低能量冲击波治疗远端周围血管疾病
- 批准号:
8617434 - 财政年份:2014
- 资助金额:
$ 52.83万 - 项目类别:
Hypoxia and inflammatory injury in human renovascular hypertension
人类肾血管性高血压的缺氧和炎症损伤
- 批准号:
9049492 - 财政年份:2014
- 资助金额:
$ 52.83万 - 项目类别:
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