Mitigating Long-term Treatment-related Morbidity in Childhood Cancer Survivors

减轻儿童癌症幸存者的长期治疗相关发病率

基本信息

  • 批准号:
    9976463
  • 负责人:
  • 金额:
    $ 81.96万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2018
  • 资助国家:
    美国
  • 起止时间:
    2018-09-01 至 2025-08-31
  • 项目状态:
    未结题

项目摘要

Cancer Relevance and Scientific Rationale: Childhood cancer survivors are at a life-long risk of chronic health conditions; by age 50, the cumulative incidence of life-threatening/fatal chronic health conditions is 53%. The two leading causes of premature mortality in childhood cancer survivors are radiation-related subsequent neoplasms (SNs) and anthracycline-related cardiac dysfunction (CD). Radiation and anthracyclines are both used in >60% of children with cancer, and there are no plans in the foreseeable future to eliminate these agents. Although there is a dose-response relation between radiation and SN and between anthracyclines and CD (regardless of the underlying primary cancer), there is significant inter-patient variability in the risk, suggesting the moderating role of genetic predisposition. The high burden of morbidity coupled with the inter-individual variability in risk, suggests a need and an opportunity to identify patients at highest risk for treatment-related morbidity, such that targeted interventions can be instituted. Broad Plan: This application harnesses and merges novel concepts from the field of molecular biology, pharmacogenomics and cancer survivorship to identify cancer patients by their personal risk of SN or CD. This award also attempts to understand the molecular pathogenesis of these complications to inform future development of targeted prevention/therapeutic strategies. The necessary infrastructure for the proposed research, including banked, annotated biospecimens (n=13,450) and pre-existing collaborations with the necessary expertise will be leveraged in this application. The goals are to: i) develop a risk prediction model for radiation-related SN and anthracycline-related CD in childhood cancer survivors; ii) replicate the optimized model in an independent cohort of childhood cancer survivors; iii) apply the optimized model to newly-diagnosed children with cancer to predict the risk of incident SN/CD; iv) determine the functional relevance of the genetic signatures. Qualifications: I am the founding Director of the Institute for Cancer Outcomes and Survivorship at the University of Alabama at Birmingham. I have over 20y of experience conducting cancer outcomes research that bridges the fields of oncology, epidemiology and genetics. Since 2000, I have been charged with shaping the pediatric oncology survivorship research agenda within the Children's Oncology Group – an NCI-supported clinical trials group, devoted exclusively to pediatric cancer research across 220 centers. I am currently serving as chair-elect for the ASCO survivorship committee. I am a Leukemia Lymphoma Scholar, a recipient of the Frank H Oski award, and am an elected member of the American Society of Clinical Investigation, and the Association for American Physicians. I have been continuously funded by NCI since 2000. With over 235 peer-reviewed publications and 15,220 citations (9,300 since 2012), my Google Scholar H-INDEX is 66 (54 since 2012) and my i10-index is 182 (167 since 2012). I am fully committed to improving the long-term health of our childhood cancer survivors, and I strongly believe that findings from this application will accelerate the pace to reduce the burden of morbidity in this population.
癌症相关性和科学依据:儿童癌症幸存者终身面临慢性健康风险

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

SMITA BHATIA其他文献

SMITA BHATIA的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('SMITA BHATIA', 18)}}的其他基金

BMT Survivor Study-2 (BMTSS-2)
BMT 幸存者研究 2 (BMTSS-2)
  • 批准号:
    9904585
  • 财政年份:
    2019
  • 资助金额:
    $ 81.96万
  • 项目类别:
BMT Survivor Study-2 (BMTSS-2)
BMT 幸存者研究 2 (BMTSS-2)
  • 批准号:
    10372068
  • 财政年份:
    2019
  • 资助金额:
    $ 81.96万
  • 项目类别:
BMT Survivor Study-2 (BMTSS-2)
BMT 幸存者研究 2 (BMTSS-2)
  • 批准号:
    10590723
  • 财政年份:
    2019
  • 资助金额:
    $ 81.96万
  • 项目类别:
Mitigating Long-term Treatment-related Morbidity in Childhood Cancer Survivors
减轻儿童癌症幸存者的长期治疗相关发病率
  • 批准号:
    9754794
  • 财政年份:
    2018
  • 资助金额:
    $ 81.96万
  • 项目类别:
Mitigating Long-term Treatment-related Morbidity in Childhood Cancer Survivors
减轻儿童癌症幸存者的长期治疗相关发病率
  • 批准号:
    10468239
  • 财政年份:
    2018
  • 资助金额:
    $ 81.96万
  • 项目类别:
Mitigating Long-term Treatment-related Morbidity in Childhood Cancer Survivors
减轻儿童癌症幸存者的长期治疗相关发病率
  • 批准号:
    10682635
  • 财政年份:
    2018
  • 资助金额:
    $ 81.96万
  • 项目类别:
Mitigating Long-term Treatment-related Morbidity in Childhood Cancer Survivors
减轻儿童癌症幸存者的长期治疗相关发病率
  • 批准号:
    10246837
  • 财政年份:
    2018
  • 资助金额:
    $ 81.96万
  • 项目类别:
Comprehensive Approach to Improve Medicine Adherence in Pediatric Leukmia
提高小儿白血病药物依从性的综合方法
  • 批准号:
    9390033
  • 财政年份:
    2014
  • 资助金额:
    $ 81.96万
  • 项目类别:
Comprehensive Approach to Improve Medicine Adherence in Pediatric Leukemia
提高小儿白血病用药依从性的综合方法
  • 批准号:
    8626018
  • 财政年份:
    2014
  • 资助金额:
    $ 81.96万
  • 项目类别:
Comprehensive Approach to Improve Medicine Adherence in Pediatric Leukmia
提高小儿白血病药物依从性的综合方法
  • 批准号:
    8987413
  • 财政年份:
    2014
  • 资助金额:
    $ 81.96万
  • 项目类别:

相似海外基金

Alabama Agricultural and Mechanical University ALSAMP Bridge to the Doctorate: Navigating BD Scholars’ Successful Transition to STEM Graduate Programs
阿拉巴马农业机械大学 ALSAMP 通往博士学位的桥梁:引导 BD 学者成功过渡到 STEM 研究生项目
  • 批准号:
    2404955
  • 财政年份:
    2024
  • 资助金额:
    $ 81.96万
  • 项目类别:
    Standard Grant
Conference: Second Joint Alabama--Florida Conference on Differential Equations, Dynamical Systems and Applications
会议:第二届阿拉巴马州-佛罗里达州微分方程、动力系统和应用联合会议
  • 批准号:
    2342407
  • 财政年份:
    2024
  • 资助金额:
    $ 81.96万
  • 项目类别:
    Standard Grant
IUCRC Planning Grant The University of Alabama: Center to Accelerate Recipe Development for Additive Manufacturing of Metals (CARDAMOM)
IUCRC 规划拨款阿拉巴马大学:加速金属增材制造配方开发中心 (CARDAMOM)
  • 批准号:
    2333363
  • 财政年份:
    2024
  • 资助金额:
    $ 81.96万
  • 项目类别:
    Standard Grant
RAPID: DRL AI: A Career-Driven AI Educational Program in Smart Manufacturing for Underserved High-school Students in the Alabama Black Belt Region
RAPID:DRL AI:针对阿拉巴马州黑带地区服务不足的高中生的智能制造领域职业驱动型人工智能教育计划
  • 批准号:
    2338987
  • 财政年份:
    2023
  • 资助金额:
    $ 81.96万
  • 项目类别:
    Standard Grant
Conference: Joint Alabama--Florida Conference on Differential Equations, Dynamical Systems and Applications
会议:阿拉巴马州-佛罗里达州微分方程、动力系统和应用联合会议
  • 批准号:
    2243027
  • 财政年份:
    2023
  • 资助金额:
    $ 81.96万
  • 项目类别:
    Standard Grant
Conference: HBCU Excellence in Research and EPSCoR Regional Outreach Workshop at Alabama State University (HERO-ASU)
会议:阿拉巴马州立大学 HBCU 卓越研究和 EPSCoR 区域外展研讨会 (HERO-ASU)
  • 批准号:
    2404231
  • 财政年份:
    2023
  • 资助金额:
    $ 81.96万
  • 项目类别:
    Standard Grant
RET Site: Engaging and Training Alabama STEM Teachers in Sensing Technologies
RET 网站:让阿拉巴马州 STEM 教师参与传感技术并对其进行培训
  • 批准号:
    2302144
  • 财政年份:
    2023
  • 资助金额:
    $ 81.96万
  • 项目类别:
    Standard Grant
Equipment: Facilitating Optical X-Ray Techniques for Research and Organized Training at Alabama State University (FOXTROT-ASU)
设备: 阿拉巴马州立大学 (FOXTROT-ASU) 促进光学 X 射线技术研究和组织培训
  • 批准号:
    2324575
  • 财政年份:
    2023
  • 资助金额:
    $ 81.96万
  • 项目类别:
    Standard Grant
NRT: Alabama Collaborative for Contemporary Education in Precision Timing (ACCEPT)
NRT:阿拉巴马州精密计时当代教育合作组织 (ACCEPT)
  • 批准号:
    2244074
  • 财政年份:
    2023
  • 资助金额:
    $ 81.96万
  • 项目类别:
    Standard Grant
Louis Stokes Renewal STEM Pathways and Research Alliance: Alabama LSAMP
Louis Stokes 更新 STEM 途径和研究联盟:阿拉巴马州 LSAMP
  • 批准号:
    2308715
  • 财政年份:
    2023
  • 资助金额:
    $ 81.96万
  • 项目类别:
    Continuing Grant
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了