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(1/1) Maximizing geographic and scientific reach through a Northern California APOLLO Network: application for Clinical Center

(1/1) 通过北加州 APOLLO 网络最大化地理和科学影响力：申请临床中心

基本信息

批准号：
9976509
负责人：
Chi-yuan Hsu
金额：
$ 13.33万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-25 至 2023-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9976509
关键词：
African American Alleles Allografting American Apolipoproteins Area Arizona Base Pairing Bioethics Biological Biometry Biopsy Specimen Blood California Chronic Kidney Failure Clinical Collaborations Country Data Data Analyses Donor person Elements End stage renal failure Enrollment Epidemiology Ethnic Origin European Evaluation Failure Genes Genetic Genetic Polymorphism Genotype Geographic Locations Geography Goals Habits Hawaii Health Hybrids Interdisciplinary Study Kidney Kidney Diseases Kidney Transplantation Knowledge Living Donors Longitudinal Studies Medical center Network-based Nevada New Mexico Oregon Organ Procurements Outcome Pathology Persons Prospective Studies Prospective cohort study Protocols documentation Race Registries Renal function Research Research Design Research Infrastructure Risk Sampling San Francisco Secure Site Socioeconomic Status Study models Transplant Recipients Transplantation United Network for Organ Sharing United States Universities Urine Utah Variant Washington Work clinical application clinical care clinical center comorbidity cost effective epidemiology study experience follow-up high risk improved indexing interest living kidney donor novel organ allocation racial difference rate of change response risk variant screening transplant centers transplant registry

项目摘要

PROJECT SUMMARY (1/1) Maximizing geographic and scientific reach through a Northern California APOLLO Network: application for Clinical Center We submit this application in response to RFA-DK-16-025. We propose a Northern California APOLLO Network based at University of California San Francisco (UCSF; the busiest kidney transplant center in the country), University of California Davis (UC Davis), California Pacific Medical Center (CPMC) and Stanford University. We have secured collaborations with the Association of Organ Procurement Organizations (AOPO), United Network for Organ Sharing (UNOS) and the Scientific Registry of Transplant Recipients (SRTR). We have also established relationships with 16 additional transplant centers in the western United States (in Hawaii, Washington, Oregon, Nevada, Utah, Arizona, New Mexico, and Southern California) who expressed interest in collaborating and partnering with us. We believe that our Northern California APOLLO Network will contribute importantly to the overall goal of the Consortium to better define the relationship between APOL1 risk status and outcomes among kidney transplant recipients and donors. We will join other Clinical Centers and obtain biological samples, genetic and clinical information from all African American kidney donors and the recipients of those kidneys across the United States, at baseline and longitudinally, and transmit those data and samples to the Scientific and Data Research Center (SDRC). Some strengths of our application (”Elements Unique to This Site”) are: i) inclusion of several high-volume kidney transplant centers; ii) coverage of a wide, contiguous geographic region; iii) multi-disciplinary research team with extensive experience in prospective cohort studies of kidney disease and multi-center consortia; iv) cost-effective “hybrid” model study design—jointly analyzing data collected as part of a research protocol together with data collected as part of clinical care (or entered into a registry)—that will greatly increase the number of person-years of follow-up and enhance study power; v) strong existing kidney transplant research infrastructure within the network, including ongoing bio-banking at UCSF of protocol allograft biopsy samples (and concurrent blood and urine samples), which will provide valuable information regarding renal pathology associated with APOL1 high-risk status.

项目总结