Mentoring and research in translational neuroscience of integrative medicine

中西医结合转化神经科学的指导和研究

• 批准号: 9976464
• 负责人: Helen Lavretsky
• 金额: $ 18.99万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-01 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9976464
• 关键词: Acute; Address; Aging; Anterior; Antidepressive Agents; Award; Biological Markers; Brain; Clinical; Clinical Investigator; Clinical Research; Cognition Disorders; Cognitive; Communities; Complementary Medicine; Complementary therapies; Control Groups; Data; Depressed mood; Development; Diffusion; Disease; Disease remission; Doctor of Medicine; Educational Curriculum; Educational process of instructing; Elderly; Emotional; Environment; Epigenetic Process; Escitalopram; Exhibits; Faculty; Functional Magnetic Resonance Imaging; Funding; Future; Gene Expression; Genes; Genomics; Glutamates; Graduate Degree; Grant; Health; Health Benefit; Health education; Heart failure; Hippocampus (Brain); Immunity; Impaired cognition; Inflammation; Integrative Medicine; Life; Link; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Major Depressive Disorder; Measures; Medical Students; Meditation; Memory; Mental Depression; Mental Health; Mentors; Mentorship; Meta-Analysis; Mid-Career Clinical Scientist Award (K24); Midcareer Investigator Award in Patient-Oriented Research; Mind-Body Intervention; Mood Disorders; Morbidity - disease rate; Movement; Names; National Institute of Mental Health; National Research Service Awards; Neuronal Plasticity; Neurophysiology - biologic function; Neurosciences; Outcome; Output; Parents; Patients; Pharmacotherapy; Physicians; Pilot Projects; Play; Postdoctoral Fellow; Prediction of Response to Therapy; Prevalence; Prevention; Prevention approach; Preventive; Protocols documentation; Protons; Psychiatry; Publications; Randomized; Recovery of Function; Relapse; Relaxation; Research; Research Personnel; Research Project Grants; Research Training; Resources; Rest; Role; Sampling; Schedule; Short-Term Memory; Standardization; Structure; Suicide; System; Tai Ji; Targeted Research; Testing; Time; Training; Training Programs; Training and Education; Translational Research; Treatment Efficacy; Tsunami; United States National Institutes of Health; Viral; Waiting Lists; White Matter Hyperintensity; arm; base; career; career development; cognitive performance; depressive symptoms; diffusion anisotropy; doctoral student; evidence base; executive function; experience; follow-up; gamma-Aminobutyric Acid; genomic biomarker; geriatric depression; high risk; imaging biomarker; improved; inflammatory marker; innovative technologies; interest; memory process; mood symptom; mortality; multimodality; neuroimaging; neuromechanism; neuroregulation; next generation; patient oriented; patient oriented research; perfusion imaging; peripheral blood; personalized intervention; predicting response; professor; programs; prospective; relating to nervous system; response; response biomarker; secondary outcome; symptomatic improvement; transcriptome; translational neuroscience; treatment response; vaccine response

Abstract/Summary Patient-oriented translational research in complementary and integrative medicine (CIM) has an urgent need for developing a pipeline of qualified investigators given increased public interest in the use of CIM approaches and the limited evidence base for their efficacy for treatment and prevention of major disorders. The next generation of CIM researchers will benefit from the dedicated mentorship of experienced midcareer clinical investigators. Helen Lavretsky, M.D., M.S., a Professor of Psychiatry at UCLA, was named the Semel Scholar in Integrative Mental Health, and is a clinical investigator dedicated to patient-oriented research in integrative medicine and mental health. Dr. Lavretsky has a strong record of research, publication, teaching and mentoring. Her mentored K23 (2001-2007), and the first K-24 (2010-2015) career development grants from the NIMH, and several subsequent R01 research grants from the NIMH and NCCIH focused on developing combination and complementary treatment and prevention approaches for late-life mood and cognitive disorders. Dr. Lavretsky mentors junior faculty, graduate and post-doctoral students, resident physician, and medical students. Of the 22 trainees mentored during the first K24 award, 11 (50%) now have their own NIH grants or other career grants, and others are still engaged in clinical research and training. This proposed K24 Midcareer Investigator Award in Patient-Oriented Research will provide protected time and help expand Dr. Lavretsky's research and mentoring program in translational neuroscience of mind-body interventions, and to extend mentorship to junior CIM investigators. The main aims of this program will be: 1: Testing the health benefits of mind-body interventions; 2: Applying innovative technologies to test the neuroplastic and genomic mechanisms of action of integrative medicine therapies; and 3: Developing the pipeline of future researchers of CIM. Dr. Lavretsky is developing a curriculum for training of junior investigators in translational science of integrative medicine for the UCLA CTSI program, as well as a Graduate Degree course in positive neuroscience of integrative medicine, and plans to submit an application to NCCIH for a T-32 NRSA Institutional Research Training Grant in the next two years. These training grants will allow the development of a CIM-targeted research training program at the UCLA. Combined with existing resources and reputation of the UCLA CTSI and Collaborative Centers for Integrative Medicine, this would attract an increasing pool of the most qualified and promising future CIM researchers. The proposed research and additional training will build upon findings from previous research; especially the NCCIH-funded R-01 study of Tai Chi. The K-24 award proposed project will expand to the pilot studies of multimodal MRI to focus on 1) a pilot study of MRS/ DTI/ fMRI, and 2) gene expression predictors of response to Tai Chi. This K24 application aims to provide mentoring and a research environment to develop an exceptionally strong and diverse group of CIM researchers who will play leading roles in the future of integrative medicine research.

摘要/总结 迫切需要以患者为中心的补充和整合医学（CIM）转化研究 鉴于公众对使用 CIM 方法的兴趣日益浓厚，开发了一批合格的研究人员 其治疗和预防重大疾病功效的证据基础有限。下一个 一代 CIM 研究人员将受益于经验丰富的中期临床临床的专门指导 调查人员。海伦·拉夫列茨基 (Helen Lavretsky)，医学博士、理学硕士，加州大学洛杉矶分校精神病学教授，被任命为塞梅尔学者 综合心理健康博士，是一名临床研究者，致力于以患者为导向的综合心理健康研究 医学和心理健康。拉夫列茨基博士在研究、出版、教学和 指导。她指导了 K23 (2001-2007)，并获得了第一批 K-24 (2010-2015) 职业发展补助金 NIMH 以及随后 NIMH 和 NCCIH 提供的几项 R01 研究资助重点关注开发 针对晚年情绪和认知的组合和补充治疗和预防方法 失调。拉夫列茨基博士指导初级教师、研究生和博士后学生、住院医师和 医学生。在首届 K24 奖项期间接受指导的 22 名学员中，11 名 (50%) 现在拥有自己的 NIH 补助金或其他职业补助金，其他人仍在从事临床研究和培训。 拟议的 K24 职业生涯中期研究者奖以患者为导向的研究将提供受保护的时间和 帮助扩大拉夫列茨基博士在身心转化神经科学方面的研究和指导项目 干预措施，并向初级 CIM 研究人员提供指导。该计划的主要目标是： 1： 测试身心干预措施的健康益处； 2：应用创新技术进行测试 综合医学疗法的神经塑性和基因组作用机制； 3：开发 CIM 未来研究人员的管道。拉夫列茨基博士正在开发初级培训课程 加州大学洛杉矶分校 CTSI 项目的整合医学转化科学研究人员，以及 综合医学积极神经科学研究生学位课程，并计划提交申请 NCCIH 在未来两年内申请 T-32 NRSA 机构研究培训补助金。这些培训补助金将 允许在 UCLA 开发针对 CIM 的研究培训计划。结合现有 加州大学洛杉矶分校 CTSI 和综合医学合作中心的资源和声誉，这将 吸引越来越多最有资格和最有前途的未来 CIM 研究人员。拟议的研究 额外的培训将建立在先前研究结果的基础上；特别是 NCCIH 资助的 R-01 太极拳研究。 K-24 奖项拟议项目将扩展到多模态 MRI 的试点研究，以重点关注 1) MRS/DTI/fMRI 初步研究，2) 太极反应的基因表达预测因子。这个K24 应用程序旨在提供指导和研究环境，以发展异常强大和 多元化的 CIM 研究人员群体将在未来的综合医学研究中发挥主导作用。

项目成果

Yoga Prevents Gray Matter Atrophy in Women at Risk for Alzheimer's Disease: A Randomized Controlled Trial.

• DOI: 10.3233/jad-215563
• 发表时间: 2022
• 期刊: JOURNAL OF ALZHEIMERS DISEASE
• 影响因子: 4
• 作者: Krause-Sorio, Beatrix;Siddarth, Prabha;Kilpatrick, Lisa;Milillo, Michaela M.;Aguilar-Faustino, Yesenia;Ercoli, Linda;Narr, Katherine L.;Khalsa, Dharma S.;Lavretsky, Helen
• 通讯作者: Lavretsky, Helen