2020 Protein Procession, Trafficking and Secretion GRC/GRS

2020 蛋白质加工、运输和分泌 GRC/GRS

• 批准号: 9978451
• 负责人: Alan D Attie
• 金额: $ 1.1万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-04-19 至 2022-08-19
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9978451
• 关键词: Acetylation; African American; Alzheimer' s Disease; Antigen Presentation; Behavioral; Biogenesis; Cell Adhesion; Cell physiology; Cellular biology; Collaborations; Diabetes Mellitus; Discipline; Disease; Endocrine System Diseases; Environment; Faculty; Financial Support; Heart; Hormone secretion; Hybrids; London; Malignant Neoplasms; Mass Spectrum Analysis; Membrane Lipids; Methods; Microscopy; Obesity; Organelles; Parkinson Disease; Pathway interactions; Peptide Hydrolases; Peptide Signal Sequences; Peptides; Phosphorylation; Play; Post-Translational Protein Processing; Postdoctoral Fellow; Protein-Folding Disease; Proteins; Research; Research Personnel; Role; Scientist; Signal Pathway; Signaling Protein; Structure of beta Cell of islet; Time; Woman; Work; autism spectrum disorder; career; college; cost; detection of nutrient; distraction; exosome; experience; glycosylation; graduate student; human disease; insulin regulation; insulin secretion; interest; lipid transport; meetings; membrane biogenesis; nervous system disorder; posters; programs; protein aggregation; protein misfolding; proteostasis; symposium; trafficking; training opportunity; tumor growth; urban setting

Project Summary The secretory pathway plays a central role in a staggering number of basic cellular processes, including organelle biogenesis, proteostasis, regulated hormone secretion, antigen presentation, cell adhesion, and tumor growth. In addition, lipid trafficking employs the secretory apparatus and is crucial for proper membrane biogenesis and lipid signaling pathways. Consequently, this pathway is at the heart of a wide range of human diseases, including neurological diseases (Alzheimer's, Parkinson's), behavioral diseases (autism), cancer, obesity, and endocrine diseases, most notably diabetes. The Protein Processing, Trafficking and Secretion Gordon Research Conference will bring together the following topics related to cell biology in the context of human disease: protein folding and misfolding, glycosylation in the secretory pathway, regulation of insulin secretion and nutrient sensing in pancreatic b-cells, protein aggregation in the context of neurological diseases, lipid transport in the secretory pathway, proteases in the secretory pathway, and exosomes. In addition, the conference will emphasize two types of methods that have been critically important in this field; microscopy and mass spectrometry. The combination of topics and themes makes this a unique conference with a unique niche in several fields. A major feature of this conference is the inclusion and participation of trainees and early-stage investigators. The speakers at the 2020 Conference will be comprised of 44% women, 2 African-Americans, and one Ethiopean-Australian. At the 2018 Conference, 47% of the attendees were graduate students and post-docs, more than the Gordon Conference average of 41%. All of the speakers listed in the preliminary program have accepted our invitation. We have reserved 12 speaker slots for short presentations chosen from the submitted abstracts. The conference venue is Colby Sawyer College, in New London, NH. It provides excellent facilities for a low cost. The venue is a pleasant environment that is free from the distractions of an urban setting, providing ample time and space for informal interactions. Historically, this has resulted in numerous collaborations and extensive networking. For young scientists, this leads to valuable career-long relationships.

项目摘要 分泌途径在数量惊人的基本细胞过程中发挥着核心作用， 包括细胞器生物发生、蛋白质稳态、调节激素分泌、抗原呈递 细胞粘附和肿瘤生长。此外，脂质运输利用分泌器 并且对于适当的膜生物发生和脂质信号传导途径至关重要。因此，这 这一通路是包括神经系统疾病在内的一系列人类疾病的核心 （阿尔茨海默氏症，帕金森氏症），行为疾病（自闭症），癌症，肥胖和内分泌 疾病，尤其是糖尿病。蛋白质的加工、运输和分泌 研究会议将汇集与细胞生物学相关的以下主题， 蛋白质折叠和错误折叠，分泌途径中的糖基化， 胰腺B细胞中胰岛素分泌和营养感测的调节， 神经系统疾病的背景，分泌途径中的脂质转运， 分泌途径和外泌体。此外，会议将强调两种类型的 在这一领域至关重要的方法;显微镜和质谱法。 主题和主题的结合使这成为一个独特的会议，具有独特的利基， 几个领域。本次会议的一大特点是学员的包容和参与 和早期调查员2020年会议的发言人将由44% 两名非裔美国人，一名澳大利亚人。在2018年的会议上，47%的 与会者是研究生和博士后，比戈登会议更多 平均41%。所有在初步计划中列出的发言者都接受了我们的 邀请.我们已预留12个讲者名额，供从提交的 摘要。会议地点是新罕布什尔州新伦敦的科尔比索耶学院。它提供 优良的设施，低成本。场地是一个愉快的环境，是免费的， 城市环境的干扰，为非正式的互动提供充足的时间和空间。 从历史上看，这导致了许多合作和广泛的网络。为年轻 科学家，这导致了宝贵的职业生涯长期的关系。