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Cryo-Electron Microscopy and Tomography Core

Cryo-Electron Microscopy and Tomography Core
冷冻电子显微镜和断层扫描核心
批准号：
9977948
负责人：
Peijun Zhang
金额：
$29.74万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
项目状态：
已结题
起止时间：
2007-08-27 至 2022-07-31
来源：
https://reporter.nih.gov/project-details/9977948
关键词：
BuffersComplementComplexCore ProteinCryoelectron MicroscopyDetectionDevicesHIVHIV-1HeterogeneityMethodologyMethodsMicroscopicMolecular ConformationMorphologyNegative StainingParticle SizePlayProteinsResolutionRoleSamplingStructural ProteinStructureX-Ray Crystallographybaseelectron tomographyimage reconstructionimprovedinstrumentationparticleprotein complexprotein structure

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中文摘要
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英文摘要
Cryo-EM Core Abstract The Cryo-EM Core will be an important component of the PCHPI structure determination pipeline, playing a major role in Project 1 and significantly contributing to Projects 2, 3 and 4, and tackling new HIV-host protein complexes as they become available. The Core will screen complexes produced in the Protein Core or by collaborators for their suitability for Cryo-EM or Cryo-ET structure determination and will determine the structures of HIV-host protein complexes at atomic or near-atomic resolution, using single particle methodologies. In addition, the Cryo-EM Core will develop methods to analyze structural heterogeneity within samples, an issue that complicates current EM-based analytical approaches.
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Cryo EM/ET Core
Cryo EM/ET Core
Structure and function of membrane receptor signaling complex in bacterial chemot
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国内基金
海外基金
Complement C6蛋白抑制DNA损伤修复增敏甲状腺乳头状癌放射性碘治疗的作用及其机制
  • 批准号：
    --
  • 项目类别：
    青年科学基金项目
  • 资助金额：
    30万元
  • 批准年份：
    2022
  • 负责人：
    刘宇佳
  • 依托单位：
    杭州医学院