Understanding the role of methionine oxidation in amyloid formation

了解蛋氨酸氧化在淀粉样蛋白形成中的作用

• 批准号: DP110103528
• 负责人: A/Prof Michael Griffin
• 金额: $ 28.5万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2015-06-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP110103528
• 关键词: Understanding; role; methionine; oxidation; amyloid

Amyloid deposition is associated with many debilitating systemic and neurological diseases, including Alzheimer's disease. This project aims to understand the effect of protein oxidation on the process of amyloid fibril formation. This knowledge will assist in the discovery of the triggers of these disorders and may identify methods of combating them.

淀粉样蛋白沉积与许多衰弱的全身和神经系统疾病有关，包括阿尔茨海默病。本项目旨在了解蛋白质氧化对淀粉样原纤维形成过程的影响。这一知识将有助于发现这些疾病的诱因，并可能确定与之抗争的方法。