The early structural assembly of high-density lipoproteins

高密度脂蛋白的早期结构组装

• 批准号: DP170104046
• 负责人: A/Prof Michael Griffin
• 金额: $ 26.52万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP170104046
• 关键词: early; structural; assembly; density; lipoproteins

This project aims to study the interaction between proteins and lipids, a fundamental aspect of cellular processes in all organisms. Lipid binding by apoA-I forms high-density lipoproteins (HDL) in the bloodstream, which removes cholesterol from the body. This project will define the types of lipids that bind first to the apolipoprotein (apo) A-I and the structural mechanisms of this process. The conformation of lipid binding proteins often changes during lipid binding. However, the structural mechanisms and conformational rearrangements are poorly understood. This project expects to understand the function of HDL and the structural mechanisms of lipid binding proteins in general. The results will have far-reaching applications in biology, human health, and biotechnology, including food and biopharmaceutical processing.

该项目旨在研究蛋白质和脂质之间的相互作用，这是所有生物体细胞过程的一个基本方面。载脂蛋白A-I与脂质结合，在血液中形成高密度脂蛋白（HDL），将胆固醇从体内清除。该项目将定义首先与载脂蛋白（apo）A-I结合的脂质类型以及该过程的结构机制。脂质结合蛋白的构象在脂质结合过程中经常发生变化。然而，结构机制和构象重排知之甚少。本计画希望能了解高密度脂蛋白的功能及一般脂质结合蛋白的结构机制。研究结果将在生物学、人类健康和生物技术（包括食品和生物制药加工）方面产生深远的应用。