Methodologic Core

方法论核心

• 批准号: 9979769
• 负责人: PATRICK J HEAGERTY
• 金额: $ 15.27万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-21 至 2022-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9979769
• 关键词: Adopted; Algorithms; Biomedical Research; Characteristics; Clinic; Clinical Informatics; Clinical Research; Clinical Services; Clinical Trials; Code; Collaborations; Collection; Computerized Medical Record; Conduct Clinical Trials; Data; Data Collection; Data Science; Development; Diagnosis; Diagnostic; Disease; Dose; Elements; Fostering; Foundations; Goals; Health Services Research; Health Technology; Informatics; Information Retrieval; Infrastructure; International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10); Lead; Leadership; Machine Learning; Medical Imaging; Methodology; Methods; Mission; Modernization; Monitor; Musculoskeletal; Musculoskeletal Diseases; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Natural Language Processing; Outcome; Patient Care; Patient Outcomes Assessments; Patients; Pharmaceutical Preparations; Pharmacy facility; Phase; Phenotype; Positioning Attribute; Pragmatic clinical trial; Prevention; Procedures; Process; Provider; Radiology Specialty; Randomized; Reporting; Reproducibility; Research; Research Design; Secure; Statistical Methods; Structure; System; Telephone; Universities; Use Effectiveness; Visualization software; Washington; clinical center; comparative effectiveness; computerized data processing; convolutional neural network; data management; data quality; data visualization; design; electronic structure; flexibility; health care delivery; health care service utilization; image processing; mHealth; machine learning method; novel; operation; patient subsets; quality assurance; research data dissemination; statistics; trial design

The goal of the Methodologic Core is to support high-impact clinical research focusing on the diagnosis, treatment, and prevention of musculoskeletal diseases. Specifically, the Methodologic Core will provide the contemporary data science infrastructure necessary for studies that leverage electronic medical records (EMR), and for trials that collect patient reported outcomes. We will organize around three major activities: rigorous and novel study designs; secondary use of EMR data for research; and primary data collection and pragmatic clinical trial conduct. In particular, the linkage of multiple EMR systems is opening new opportunities for large-scale clinical research, but also demands new methods for the extraction of reliable information, and for the design of trials that can tailor to the characteristics of patients and health care delivery systems. The University of Washington Center for Biomedical Statistics (CBS) has provided informatics and statistical leadership to multiple observational and randomized studies focusing on musculoskeletal disorders, and is uniquely positioned to provide the foundation for expanded impact within the broad scope of the NIAMS mission.

方法学核心的目标是支持高影响力的临床研究，重点是 肌肉骨骼疾病的诊断、治疗和预防。具体来说，方法论 核心将提供研究所需的当代数据科学基础设施， 利用电子病历（EMR），以及收集患者报告结果的试验。 我们将围绕三大活动组织：严谨新颖的研究设计;二次利用 用于研究的EMR数据;以及原始数据收集和实用的临床试验实施。在 特别是多个电子病历系统的联动，为大规模电子病历的发展带来了新的机遇 临床研究，但也需要新的方法来提取可靠的信息， 设计适合患者和医疗服务特点的试验 系统.华盛顿大学生物医学统计中心（CBS）提供了 多项观察性和随机研究的信息学和统计学领导力， 在肌肉骨骼疾病，并具有独特的地位，为扩大 在NIAMS使命的广泛范围内的影响。