Radial Echo Volumar Imaging

径向回波容积成像

• 批准号: 9980730
• 负责人: Victor Andrew Stenger
• 金额: $ 32.51万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-15 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9980730
• 关键词: 3-Dimensional; Acceleration; Algorithms; Benign; Brain; Brain imaging; Breathing; Computer software; Detection; Development; Diffusion; Dimensions; Echo-Planar Imaging; Frequencies; Functional Magnetic Resonance Imaging; Healthcare; Image; Magnetic Resonance Imaging; Maps; Methodology; Methods; Modeling; Modernization; Modification; Morphologic artifacts; Motion; Nature; Noise; Periodicity; Phase; Physiologic pulse; Physiological; Predisposition; Property; Protons; Radial; Research Personnel; Research Project Grants; Research Project Summaries; Research Proposals; Resolution; Rest; Rotation; Running; Sampling; Scanning; Scheme; Signal Transduction; Slice; Speed; Structure; Techniques; Technology; Time; Translations; base; blood oxygen level dependent; density; flexibility; image reconstruction; imaging approach; imaging modality; improved; innovation; interest; motion sensitivity; novel; perfusion imaging; reconstruction; resilience; success; temporal measurement

Project Summary This research project “Radial Echo Volumar Imaging” proposes the development of MRI acquisition and reconstruction methods based on a novel versatile non-Cartesian sampling concept for fast motion-corrected imaging. The technique expands upon Echo Planar Imaging (EPI), which is the most widely utilized fast MRI acquisition and is the standard method for various applications ranging from functional MRI to diffusion and perfusion imaging. Recently EPI has also been shown to be promising for rapid structural imaging including simultaneous multi-parametric MRI. Most modern EPI approaches are based on volumetric imaging methods as they permit high isotropic spatial resolution, improved Signal to Noise Ratio per unit time, and parallel imaging acceleration along the third dimension. A challenge of volumetric imaging however is the requirement for segmentation due to gradient and physiological limitations that leads to increased motion sensitivity and other physiological effects. Radial sampling offers several advantages with regards to segmented acquisitions including robustness to motion due to intrinsic self-navigation from oversampling the center of k-space. Radial sampling also has the benefit of producing benign “streaking” aliasing artifacts compared to Cartesian allowing for large accelerations and an efficient use of parallel imaging methods. A further advantage of radial sampling is that the in-plane dimension is sampled quickly by frequency encoding leading to higher in-plane resolution and less distortion with low time penalty. In this project we propose to utilize these advantages to develop innovative methodology for rapid and robust brain imaging that should also prove to be important for many other imaging applications including body MRI. The Scientific Premise of this proposal is that an optimal rapid MRI acquisition can be obtained by using three- dimensional radial EPI trajectories and generalized model-based reconstructions. We propose an innovative Radial Echo Volumar Imaging (REVI) acquisition created by adding gradient encoding along the third direction of a radial EPI acquisition to create SMS and 3D rotated “Stack-of-Stars” sampling for high parallel imaging acceleration while allowing for optimal tradeoffs in temporal and spatial resolutions. The self-navigation properties of the radial trajectories will provide motion robustness and continuous golden-angle rotation will permit variable temporal resolutions and reordering of the acquisition. The multi-echo nature of REVI will also allow for simultaneous multi-parametric structural scanning. The proposed technology requires no special hardware and can be run on any scanner by any investigator.

项目概要 该研究项目“径向回波体积成像”提出了 MRI 采集和成像技术的发展 基于新颖的通用非笛卡尔采样概念的快速运动校正重建方法 成像。该技术扩展了回波平面成像 (EPI)，这是使用最广泛的快速 MRI 采集，是从功能性 MRI 到扩散和扫描等各种应用的标准方法 灌注成像。最近，EPI 也被证明在快速结构成像方面具有广阔的前景，包括 同时多参数 MRI。大多数现代 EPI 方法都基于体积成像方法 因为它们允许高各向同性空间分辨率、提高每单位时间的信噪比以及并行 沿三维的成像加速度。然而，体积成像的一个挑战是要求 用于由于梯度和生理限制导致运动敏感性增加的分割 其他生理效应。 径向采样在分段采集方面具有多种优势，包括稳健性 由于对 k 空间中心进行过采样而产生的固有自导航而产生的运动。径向采样还具有 与笛卡尔相比，产生良性“条纹”混叠伪像的好处是允许大加速度 以及并行成像方法的有效使用。径向采样的另一个优点是面内采样 通过频率编码快速采样尺寸，从而实现更高的面内分辨率和更少的失真 时间惩罚低。在这个项目中，我们建议利用这些优势来开发创新方法 用于快速、稳健的脑成像，这对于许多其他成像应用也很重要 包括身体核磁共振成像。 该提案的科学前提是，可以通过使用三个来获得最佳的快速 MRI 采集： 维度径向 EPI 轨迹和基于广义模型的重建。我们提出了一个创新的 通过沿第三方向添加梯度编码创建径向回波容积成像 (REVI) 采集 径向 EPI 采集以创建 SMS 和 3D 旋转“星栈”采样以实现高并行成像 加速，同时允许时间和空间分辨率的最佳权衡。自我导航 径向轨迹的特性将提供运动鲁棒性，并且连续的黄金角旋转将 允许可变的时间分辨率和采集的重新排序。 REVI 的多回波性质也将 允许同时进行多参数结构扫描。所提出的技术不需要特殊的 硬件，可以由任何调查员在任何扫描仪上运行。