Quantitative Magnetic Resonance Imaging Phantoms

定量磁共振成像体模

基本信息

  • 批准号:
    9980388
  • 负责人:
  • 金额:
    $ 74.51万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2019
  • 资助国家:
    美国
  • 起止时间:
    2019-08-01 至 2023-05-31
  • 项目状态:
    已结题

项目摘要

PROJECT SUMMARY The overall goal of this SBIR Phase II proposal is to refine and evaluate advanced quantitative magnetic resonance imaging (MRI) phantoms that mimic the simultaneous presence of fat, iron and fibrosis. Fat, iron and fibrosis are three principal histological coexisting features of many important disease states. Phantoms are highly controlled test objects that accurately reflect tissue characteristics in both normal and pathological tissues. Emerging quantitative MRI methods introduced in the past ~5 years are increasingly used for non- invasive diagnosis, staging and treatment monitoring in both clinical care and clinical trials. However, the lack of viable MRI phantoms that mimic the combination of fat, iron and fibrosis experienced in disease states is a major barrier to the development of new quantitative MRI biomarkers, as well as effective quality assurance in clinical environments. Such phantoms are also needed for quality assurance and qualification of MRI scanners for use in multicenter drug development trials. This collaborative Phase II proposal between Calimetrix, LLC, and the University of Wisconsin-Madison will build upon the successful proof-of-concept prototype developed in an STTR Phase I project. Specifically, this proposal will refine and evaluate novel quantitative MRI phantoms for the validation and quality assurance of MRI techniques to assess fat, iron and fibrosis in tissue. The investigative team will optimize and determine the manufacturing accuracy of the phantom (Aim 1), as well as its manufacturing precision (Aim 2), will conduct accelerated shelf-life testing (Aim 3), and will evaluate the phantom in a multi-center study across various sites, MRI vendors, and two field strengths (Aim 4). Successful design, development and validation of advanced phantoms that accurately reflect tissue characteristics are a critical step in the development and dissemination of quantitative imaging biomarkers, which will have major impact by reducing cost, improving safety, and improving early diagnosis and treatment of disease, affecting the health of millions of Americans.
项目摘要 该SBIR第二阶段提案的总体目标是完善和评估先进的定量磁 磁共振成像(MRI)幻象,其模拟脂肪、铁和纤维化的同时存在。脂肪、铁 和纤维化是许多重要疾病状态的三个主要组织学共存特征。体模是 高度受控的测试对象,准确反映正常和病理组织特征 组织中在过去的5年中,新兴的定量MRI方法越来越多地用于非MRI检查。 临床护理和临床试验中的侵入性诊断、分期和治疗监测。但缺乏 模拟疾病状态中经历的脂肪、铁和纤维化的组合的可行的MRI幻影是一种 这是开发新的定量MRI生物标志物的主要障碍, 临床环境。这样的幻影也需要质量保证和资格的MRI扫描仪 用于多中心药物开发试验。 加州大学和威斯康星大学麦迪逊分校之间的第二阶段合作提案将 基于STTR第一阶段项目中开发的成功概念验证原型。具体来说, 该提案将完善和评估新的定量MRI体模,用于验证和质量保证, MRI技术评估组织中的脂肪、铁和纤维化。调查小组将优化和确定 体模的制造精度(目标1)及其制造精度(目标2)将进行 加速有效期测试(目标3),并将在多个研究中心的多中心研究中评价体模, MRI供应商和两个场强(目标4)。成功设计、开发和验证先进的 准确反映组织特征的体模是发展和传播的关键步骤 定量成像生物标志物,这将通过降低成本,提高安全性, 改善疾病的早期诊断和治疗,影响数百万美国人的健康。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(1)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Jean H. Brittain其他文献

Jean H. Brittain的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Jean H. Brittain', 18)}}的其他基金

Advanced Quantitative Magnetic Resonance Imaging Phantoms for Nonalcoholic Fatty Liver Disease
用于非酒精性脂肪肝疾病的先进定量磁共振成像模型
  • 批准号:
    10698927
  • 财政年份:
    2023
  • 资助金额:
    $ 74.51万
  • 项目类别:

相似海外基金

Rational design of rapidly translatable, highly antigenic and novel recombinant immunogens to address deficiencies of current snakebite treatments
合理设计可快速翻译、高抗原性和新型重组免疫原,以解决当前蛇咬伤治疗的缺陷
  • 批准号:
    MR/S03398X/2
  • 财政年份:
    2024
  • 资助金额:
    $ 74.51万
  • 项目类别:
    Fellowship
CAREER: FEAST (Food Ecosystems And circularity for Sustainable Transformation) framework to address Hidden Hunger
职业:FEAST(食品生态系统和可持续转型循环)框架解决隐性饥饿
  • 批准号:
    2338423
  • 财政年份:
    2024
  • 资助金额:
    $ 74.51万
  • 项目类别:
    Continuing Grant
Re-thinking drug nanocrystals as highly loaded vectors to address key unmet therapeutic challenges
重新思考药物纳米晶体作为高负载载体以解决关键的未满足的治疗挑战
  • 批准号:
    EP/Y001486/1
  • 财政年份:
    2024
  • 资助金额:
    $ 74.51万
  • 项目类别:
    Research Grant
Metrology to address ion suppression in multimodal mass spectrometry imaging with application in oncology
计量学解决多模态质谱成像中的离子抑制问题及其在肿瘤学中的应用
  • 批准号:
    MR/X03657X/1
  • 财政年份:
    2024
  • 资助金额:
    $ 74.51万
  • 项目类别:
    Fellowship
CRII: SHF: A Novel Address Translation Architecture for Virtualized Clouds
CRII:SHF:一种用于虚拟化云的新型地址转换架构
  • 批准号:
    2348066
  • 财政年份:
    2024
  • 资助金额:
    $ 74.51万
  • 项目类别:
    Standard Grant
The Abundance Project: Enhancing Cultural & Green Inclusion in Social Prescribing in Southwest London to Address Ethnic Inequalities in Mental Health
丰富项目:增强文化
  • 批准号:
    AH/Z505481/1
  • 财政年份:
    2024
  • 资助金额:
    $ 74.51万
  • 项目类别:
    Research Grant
ERAMET - Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
ERAMET - 快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
  • 批准号:
    10107647
  • 财政年份:
    2024
  • 资助金额:
    $ 74.51万
  • 项目类别:
    EU-Funded
BIORETS: Convergence Research Experiences for Teachers in Synthetic and Systems Biology to Address Challenges in Food, Health, Energy, and Environment
BIORETS:合成和系统生物学教师的融合研究经验,以应对食品、健康、能源和环境方面的挑战
  • 批准号:
    2341402
  • 财政年份:
    2024
  • 资助金额:
    $ 74.51万
  • 项目类别:
    Standard Grant
Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
  • 批准号:
    10106221
  • 财政年份:
    2024
  • 资助金额:
    $ 74.51万
  • 项目类别:
    EU-Funded
Recite: Building Research by Communities to Address Inequities through Expression
背诵:社区开展研究,通过表达解决不平等问题
  • 批准号:
    AH/Z505341/1
  • 财政年份:
    2024
  • 资助金额:
    $ 74.51万
  • 项目类别:
    Research Grant
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了