Magnetic Resonance Imaging for Global Atherosclerosis Risk Assessment

磁共振成像用于全球动脉粥样硬化风险评估

• 批准号: 9980464
• 负责人: Janet Wei
• 金额: $ 19.84万
• 依托单位: CEDARS-SINAI MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-01 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9980464
• 关键词: Apolipoproteins B; Area; Arterial Fatty Streak; Atherosclerosis; Biological Markers; Biometry; C-reactive protein; Cardiac; Cardiology; Cardiovascular Diseases; Cause of Death; Clinical; Clinical Trials; Contrast Media; Coronary; Coronary Arteriosclerosis; Development; Discrimination; Effectiveness; Epidemiology; Event; Future; Glycosylated hemoglobin A; Hemorrhage; High Density Lipoprotein Cholesterol; Individual; Intervention; LDL Cholesterol Lipoproteins; Laboratories; Learning; Lesion; Lipoprotein (a); Magnetic Resonance Imaging; Measurement; Measures; Mentored Patient-Oriented Research Career Development Award; Mentors; Modeling; Monitor; Myocardial Infarction; Patients; Prevention strategy; Prevention trial; Preventive; Recording of previous events; Recurrence; Reproducibility; Research Methodology; Resolution; Risk; Risk Assessment; Risk Factors; Secondary Prevention; Stroke; Techniques; Thick; Time; Training; Translational Research; United States; Weight; acute coronary syndrome; adiponectin; atherosclerosis risk; cardiovascular disorder prevention; cardiovascular disorder risk; cardiovascular imaging; cardiovascular risk factor; career; clinical application; clinically significant; coronary calcium scoring; coronary computed tomography angiography; design; high risk; improved; individual patient; mortality; novel; novel therapeutics; personalized intervention; prognostic value; public health relevance; rapid technique; recruit; tool; translational scientist; treatment response; treatment strategy; vascular bed

 DESCRIPTION (provided by applicant): This application for a Mentored Patient-Oriented Research Career Development Award entitled "Magnetic Resonance Imaging for Global Atherosclerosis Risk Assessment" is being submitted by Janet Wei, MD, to continue her professional development as a translational researcher in the inter-disciplinary field of preventive cardiology and magnetic resonance imaging (MRI) measures of atherosclerosis. Cardiovascular disease (CVD) remains the leading cause of death in the United States. Secondary prevention strategies reduce but do not eliminate the risk of recurrent CVD events and many patients are treated to reduce one event. Current risk prediction is not personalized to an individual patient's atherosclerotic burden or adverse plaque features, which have now been shown to have prognostic value. Current measures of atherosclerosis burden and adverse plaque features in individual vascular beds improve prediction of CVD events over traditional risk factors, but their clinical application is not developed for risk prediction of recurrent evens or for therapeutic response monitoring. Novel techniques have been developed for assessing coronary, carotid, and femoral atherosclerosis using MRI methods that are rapid and reproducible, have improved spatial resolution, and do not require contrast media, making atherosclerosis assessment in multiple vascular beds feasible. Because the coronary vascular bed has greater risk assessment value for cardiac events than the carotid and femoral vascular beds, Dr. Wei hypothesizes that global MRI measures of plaque burden and adverse plaque features using all three vascular beds will improve CVD risk discrimination compared to currently available individual vascular bed measures and may be useful to monitor treatment response. The proposed project builds on Dr. Wei's strengths in general clinical cardiology and basic cardiovascular imaging, and she will receive additional training in [1] CVD prevention and epidemiology, [2] MRI quantification and characterization of atherosclerotic plaque, and [3] advanced biostatistics and research methodology for risk prediction. She anticipates that this training will give her the tools to apply MRI atherosclerosis models in clinical trials for the development of personalized CVD prevention and treatment strategies.

 描述（由申请人提供）：本申请为指导的患者为导向的研究职业发展奖题为“磁共振成像全球动脉粥样硬化风险评估”正在提交的珍妮特魏，医学博士，继续她的专业发展作为一个跨学科领域的预防心脏病学和磁共振成像（MRI）动脉粥样硬化措施的转化研究员。心血管疾病（CVD）仍然是美国的主要死亡原因。二级预防策略可降低但不能消除复发性CVD事件的风险，许多患者接受治疗以减少一次事件。目前的风险预测不是个性化的个体患者的动脉粥样硬化负担或不良斑块的特点，现在已经显示出具有预后价值。目前对个体血管床中动脉粥样硬化负荷和不良斑块特征的测量改善了对CVD事件的预测，超过了传统的危险因素，但其临床应用并没有被开发用于复发事件的风险预测或治疗反应监测。已经开发了使用MRI方法评估冠状动脉、颈动脉和股动脉粥样硬化的新技术，这些方法快速且可重复，具有提高的空间分辨率，并且不需要造影剂，使得在多个血管床中进行动脉粥样硬化评估可行。由于冠状动脉血管床比颈动脉和股动脉血管床对心脏事件具有更大的风险评估价值，因此Wei博士假设，与目前可用的单个血管床相比，使用所有三个血管床对斑块负荷和不良斑块特征进行全球MRI测量将改善心血管疾病风险区分措施，并且可能有助于监测治疗反应。该拟议项目建立在Wei博士在普通临床心脏病学和基础心血管成像方面的优势基础上，她将接受[1] CVD预防和流行病学，[2]动脉粥样硬化斑块的MRI定量和表征以及[3]先进的生物统计学和风险预测研究方法的额外培训。她预计，这次培训将为她提供在临床试验中应用MRI动脉粥样硬化模型的工具，以开发个性化的CVD预防和治疗策略。

项目成果

Case report: assessment and management of myocardial infarction and non-obstructive coronary arteries (MINOCA): the role of microvascular coronary vasospasm.

病例报告：心肌梗塞和非阻塞性冠状动脉（MINOCA）的评估和治疗：微血管冠状动脉痉挛的作用。

• DOI: 10.21037/cdt.2019.07.13
• 发表时间: 2019
• 期刊: Cardiovascular diagnosis and therapy
• 影响因子: 2.4
• 作者: Marpuri,ReddySailaja;Joung,Sandy;Gadh,Adit;Dhawan,Shivani;Al-Badri,Ahmed;Pacheco,Christine;Wei,Janet;Merz,CNoelBairey
• 通讯作者: Merz,CNoelBairey