UAB Research and Education Program in Neuroscience

摘要 这是阿拉巴马大学继续颁发R25研究教育奖的建议。 伯明翰(UAB)。该计划将支持神经科学领域正在追求职业生涯的住院医生 把临床实践和科研结合起来，培养他们成为内科科学家。 在过去的二十年里，人们投入了大量的努力和资源来理解 神经系统在健康和疾病中的功能，其结果是知识的巨大扩展 包括遗传学、基因组学、神经肿瘤学、神经化学、突触方面的基本发现 可塑性、神经发育和行为。然而，很明显，两国之间仍然存在着尚未弥合的差距 这些进展及其在人类健康方面的应用。迫切需要下一代内科医生-科学家 包括：i)将关于神经系统的几个领域的发现整合到多模式和多模式中 维度框架；以及二)制定翻译途径，将这一知识应用于重要的 生物医学和行为问题。 这项更新提案中的新的和令人兴奋的倡议如下：1)大卫·斯坦德尔特博士 继续担任项目主任，但他已与新任副主任中野一郎博士合作；2) 范围已经扩大，现在不仅包括神经学、神经外科和神经病理学，而且 与NINDS任务一致的工作区内的放射科和麻醉科住院医师；3) 导师们围绕四个主题组织起来，即神经肿瘤学、神经退行性变、突触 可塑性和脑血管疾病；4)教学成分得到加强，包括在 实验的严格性。 方案主任和副主任都是有既定轨道的内科科学家 研究和培训方面的记录。受该计划支持的居民将在他们的 住院医师培训，并在实习结束后继续提供研究奖学金。来自所有国家的参与者 各学科将进行为期两年的全日制科研培训。他们的研究经验将是 由结构化的指导计划支持，并在严格的专业实验教学中提供支持 技能培训、拨款撰写和负责任的研究行为。该计划的目标将是使 住院医生和研究员在神经学研究领域发展事业，并为他们成功地 竞争个人奖学金或指导职业发展奖。作为一家机构，UAB是 非常适合从事神经科学的研究教育，并开发 内科医生--将应用今天的发现来解决明天的挑战的科学家。

Abstract This is a proposal for continuation of an R25 research education award at the University of Alabama at Birmingham (UAB). This program will support residents in neuroscience fields who are pursuing careers combining clinical practice and research, and foster their development as physician-scientists. Over the past two decades, considerable efforts and resources have been devoted to understanding nervous system function in health and disease, and the result has been a vast expansion of knowledge encompassing fundamental discoveries in genetics, genomics, neuro-oncology, neurochemistry, synaptic plasticity, neural development, and behavior. It is clear, however, that there remains an unmet gap between these advances and applications to human health. A pressing need for next-generation physician-scientists includes: i) integrate discoveries about the nervous system from several domains into multi-modal and multi- dimensional frameworks; and ii) formulate translational pathways to apply this knowledge to important biomedical and behavioral problems. The new and exciting initiatives in this renewal proposal are as follows: 1) Dr. David Standaert continues as Program Director, but he has been teamed with the new Associate Director, Dr. Ichiro Nakano; 2) the scope has been expanded and now includes not only neurology, neurosurgery, and neuropathology but also radiology and anesthesiology residents who are working areas consistent with the NINDS mission; 3) the mentors have been organized around the four themes, that is, neuro-oncology, neurodegeneration, synaptic plasticity, and cerebrovascular disease; 4) didactic components are strengthened, including a formal course in experimental rigor. The Program Director and Associate Director are both physician-scientists with established track records in research and training. Residents supported by this program will initiate their research during their residency training, and continue it into a period of research fellowship following residency. Participants from all disciplines will engage in a total of two years in full time research training. Their research experience will be supported by a structured mentoring program along with didactic teaching in experimental rigor, professional skills training, grant writing, and responsible conduct of research. The goal of the program will be to enable residents and fellows to develop a career in neurological research, and to prepare them to successfully compete for individual fellowships or mentored career development awards. As an institution, UAB is exceptionally well positioned to undertake research education in the neurosciences, and to develop the physician-scientists who will apply today’s discoveries to solve the challenges of tomorrow.