UAB Training Program In Neuroscience

摘要 这是一个新的T32培训计划在伯明翰（UAB）的亚拉巴马大学的建议。这是一 针对神经退行性疾病基础和转化方法的博士前学生的重点课程。 建立这一新计划的理由是基于三个关键因素：1）美国的老龄化 人口，这将很快导致受神经退行性疾病影响的患者数量的增长， 2)神经科学工具和技术的快速发展，以及3）对 神经科学作为一个学科的博士生。该培训计划的主要目标是实现跨- 文化培训;我们寻求让学生接触生物机制和研究方法 在神经退行性疾病，而不是那种单一的疾病培训，他们可能会得到工作在一个 个人研究实验室。该计划将为高级博士预科学生提供支持， 研究阶段的训练。大多数学生将进入神经变性训练计划从 UAB研究生生物医学科学计划，每年招收约80名学生，或UAB医学 科学家培训计划，每年招收8名学生。计划的培训任用期 每个学生的课程是两年。第1年共申请2个名额，随后申请4个名额 年学生将在24位高素质导师之一的监督下工作。其中三个是初级的 导师，并有计划的导师发展和共同辅导。该计划包含所需的 第一年和第二年的神经变性教学课程工作，一个新开发的正式课程 在实验的严谨性，新工具和技术的培训，在翻译途径和药物教学 发展，神经退行性疾病杂志俱乐部，年度务虚会，导师和成果评估。 我们的核心理念是，我们寻求通过提供一个强大的培训途径， 翻译研究这种独特的重点将使我们的学生在治疗中发挥主导作用 在提供至关重要的服务所需的不同技能组合和企业范围内进行发现， 需要未来的治疗。

Abstract This is a proposal for a new T32 training program at the University of Alabama at Birmingham (UAB). This is a focused program for predoctoral students in basic and translational approaches to neurodegenerative disease. The rationale for establishing this new program is founded on three critical factors: 1) The aging of the US population, which will soon lead to growth in the numbers of patients affected by neurodegenerative disease, 2) Rapid advances in tools and technologies in the neurosciences, and 3) The increasing interest in neurosciences as a discipline by PhD students. A primary goal of this Training Program is to achieve cross- cultural training; we seek to expose students to the biological mechanisms and research approaches used across neurodegenerative disease, rather than the kind of single-disease training they might get working in an individual research laboratory. This program will provide support for advanced pre-doctoral students in the research phase of their training. Most students will enter the Neurodegeneration Training Program from the UAB Graduate Biomedical Science Program, which admits about 80 students annually, or the UAB Medical Scientist Training Program, which admits 8 students annually. Planned duration of appointment to the training program is two years for each student. A total of 2 slots are requested in Year 1, and 4 slots in subsequent years. Students will work under the supervision of one of 24 highly qualified mentors. Three of these are junior mentors, and there are plans for mentor development and co-mentoring. The program incorporates required didactic course work in neurodegeneration in both the first and second years, a newly developed formal course in experimental rigor, training in new tools and technologies, instruction in the translational pathway and drug development, a journal club on Neurodegeneration, an annual retreat, and mentor and outcomes evaluations. Our core philosophy is that we seek to enable the cures of the future by providing a robust training pathway in translational research. This unique emphasis will enable our students to take leading roles in therapeutic discovery across the spectrum of different skills sets and enterprises which are required to deliver the vitally needed treatments of the future.