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Comparative electrophysiology: Visual event-related potentials and oscillations

比较电生理学：视觉事件相关电位和振荡

基本信息

批准号：
9980405
负责人：
GEOFFREY F WOODMAN
金额：
$ 32.1万
依托单位：
VANDERBILT UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-12-01 至 2022-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9980405
关键词：
Address Animal Model Area Attention Brain Brain region Cognitive Cohort Studies Complex Data Diagnosis Disease Electrodes Electroencephalogram Electrophysiology (science)Elements Event-Related Potentials Exhibits Feedback Frequencies Funding Goals Grant Head Health Human Image Individual Information Storage Macaca Magnetic Resonance Imaging Measures Medial Methods Microelectrodes Modeling Monitor Monkeys Nature Neurologic Neurons Output Performance Prefrontal Cortex Primates Process Psychologist Research Research Personnel Short-Term Memory Surface Task Performances Testing Tissue Model Visual Visual attention Visual system structure Work brain health comparative electric field executive function human data indexing information processing innovation neural model nonhuman primate operation programs relating to nervous system response source localization success temporal measurement theories tool visual cognition visual control visual information visual performance visual processing

项目摘要

Human visual event-related potentials (ERPs) and the electroencephalogram (EEG) measure a variety of different cognitive operations during visual processing. Visual ERPs and EEG are vital tools in diagnosing and studying neurological and psychopathological disorders, in addition to revealing how the health brain turns visual inputs into appropriate responses. However, it is not possible to definitively determine what brain areas generate specific ERP components and EEG oscillations related to deploying visual attention, visual working memory storage, and monitoring task performance. The renewal of this project will support our work localizing the sources of ERP components and oscillatory signatures elicited during the performance of visual tasks using both humans and nonhuman primates. In the latter we will record noninvasive ERPs and EEG simultaneously with intracranial recordings of local field potentials. These recordings will be used to perform forward modeling of the neural generators from inside the head. Preliminary evidence from monkeys and humans performing identical visual tasks demonstrates homology between human and macaque ERP components and the modulation of specific frequency bands in the EEG providing indices of the deployment of visual attention, the storage of visual information in visual working memory, and performance monitoring. By concurrently studying humans and monkeys this project will allow clinicians and health researchers to use the visually and response evoked EEG activity and ERP components recorded noninvasively from humans to access whether specific brain regions are functioning properly and also to develop animal models of specific disorders.

人的视觉事件相关电位（ERPs）和脑电图（EEG）测量的各种