Comparative electrophysiology: Visual event-related potentials and oscillations

人类视觉事件相关电位(ERPs)和脑电(EEG)测量了各种不同的 视觉加工过程中的不同认知操作。视觉事件相关电位和脑电是诊断和诊断脑血管疾病的重要工具 研究神经学和精神病理障碍，除了揭示健康的大脑是如何转变的 将视觉输入到适当的反应中。然而，不可能确切地确定大脑的哪些区域 生成与部署视觉注意力、视觉工作相关的特定ERP组件和EEG振荡 内存存储和监控任务性能。这个项目的续签将支持我们的本地化工作 视觉任务执行过程中诱发的事件相关电位成分来源和振荡特征 使用人类和非人类灵长类动物。在后者中，我们将记录非侵入性事件相关电位和脑电 与脑内局部场电位的记录同步。这些录音将被用来表演 从头部内部对神经生成器进行正向建模。来自猴子的初步证据和 执行相同视觉任务的人类与猕猴的事件相关电位具有同源性 脑电中特定频段的分量和调制提供了部署的指标 视觉注意，视觉信息在视觉工作记忆中的存储，以及性能监控。通过 在同时研究人类和猴子的同时，这个项目将允许临床医生和卫生研究人员使用 视觉和反应诱发的脑电活动和事件相关电位成分的非侵入性记录 访问特定的大脑区域是否正常工作，并开发特定的动物模型 精神错乱。

Human visual event-related potentials (ERPs) and the electroencephalogram (EEG) measure a variety of different cognitive operations during visual processing. Visual ERPs and EEG are vital tools in diagnosing and studying neurological and psychopathological disorders, in addition to revealing how the health brain turns visual inputs into appropriate responses. However, it is not possible to definitively determine what brain areas generate specific ERP components and EEG oscillations related to deploying visual attention, visual working memory storage, and monitoring task performance. The renewal of this project will support our work localizing the sources of ERP components and oscillatory signatures elicited during the performance of visual tasks using both humans and nonhuman primates. In the latter we will record noninvasive ERPs and EEG simultaneously with intracranial recordings of local field potentials. These recordings will be used to perform forward modeling of the neural generators from inside the head. Preliminary evidence from monkeys and humans performing identical visual tasks demonstrates homology between human and macaque ERP components and the modulation of specific frequency bands in the EEG providing indices of the deployment of visual attention, the storage of visual information in visual working memory, and performance monitoring. By concurrently studying humans and monkeys this project will allow clinicians and health researchers to use the visually and response evoked EEG activity and ERP components recorded noninvasively from humans to access whether specific brain regions are functioning properly and also to develop animal models of specific disorders.