Fred & Pamela Buffett Cancer Center Support Grant

项目概要/摘要：总体 内布拉斯加大学弗雷德和帕梅拉·巴菲特癌症中心（Fred & Pamela Buffett Cancer Center，FPBCC） 医学中心致力于开发新的治疗和预防癌症的策略， 创新的跨学科研究，一流的教育计划，最高质量的病人护理， 向得不到充分服务的人群提供服务。巴菲特癌症中心致力于减轻 癌症通过跨学科的转化癌症研究，导致癌症治疗的新疗法， 以及提高癌症幸存者的福祉。作为美国唯一一家NCI指定的癌症中心， 内布拉斯加州，我们非常敏感的服务不足的人口在我们的集水区的需求（跨 内布拉斯加州和西部爱荷华州），包括妇女、少数民族和儿童，以及医学上的 我们地区的贫困农村居民。巴菲特癌症中心的84名成员积极参与 在跨学科的FPBCC研究计划，包括分子和生化病因学 癌症基因和分子调控计划（CGMR），以及 胃肠癌计划（GICP）。FBPCC是一个矩阵，每个学院都有成员， 联合国军事委员会各研究所以及内布拉斯加大学-林肯分校和内布拉斯加大学的成员 - 奥马哈FPBCC主任还领导Eppley癌症研究所，该研究所拥有30名终身教职/终身教职领先的教师 约会. FPBCC主任直接向联合国监测委员会负责人报告，并在联合国监测委员会任职。 财政大臣理事会和内布拉斯加州医学的高级领导团队，两个最高级和 学术和临床企业的责任内阁。耗资3.23亿美元的巴菲特癌症中心 (625 2017年将在一个设施中开设癌症研究和护理，并提供充足的空间 FPBCC增长。自上次审查以来，FPBCC加强了跨学科研究合作， 为招募30名新成员提供支持（包括GICP的共同领导人和 生物信息学共享资源），用于增强共享研究设施，并用于试点资金 多学科合作研究项目。FPBCC在跨学科领域有着良好的记录， 癌症研究和强有力的合作证据桥接所有的研究计划。巴菲特癌症 中心的研究已导致1409出版物，其中23%是跨计划的合作，23% 是项目内合作，9%两者都是。FPBCC外部资助的癌症研究组合 目前每年超过3430万美元的同行评审支持（> 46% NCI）表明， 巴菲特癌症中心成员的跨学科癌症研究合作，专注于解决 癌症相关的问题。

Project Summary/Abstract: Overall The Fred & Pamela Buffett Cancer Center (Buffett Cancer Center or FPBCC) at the University of Nebraska Medical Center is committed to developing new strategies for the treatment and prevention of cancer through innovative interdisciplinary research, premier educational programs, the highest quality patient care, and outreach to underserved populations. The Buffett Cancer Center is dedicated to reducing the burden of cancer through interdisciplinary translational cancer research leading to new therapies for cancer treatment as well as enhancing the well-being of cancer survivors. As the only NCI-designated Cancer Center in Nebraska, we are very sensitive to the needs of the underserved populations in our catchment area (across the state of Nebraska and western Iowa), including women, minorities and children as well as the medically underserved rural residents in our region. The 84 members of the Buffett Cancer Center are actively involved in the interdisciplinary FPBCC Research Programs including the Molecular and Biochemical Etiology Program (MBEP), the Cancer Genes and Molecular Regulation Program (CGMR), and the Gastrointestinal Cancer Program (GICP). The FBPCC is a matrix with Members in each of the Colleges and Institutes at UNMC, as well as Members at the University of Nebraska - Lincoln and the University of Nebraska - Omaha. The FPBCC Director also leads the Eppley Cancer Institute, with 30 tenure/tenure-leading faculty appointments. The FPBCC Director reports directly to the Chancellor of UNMC and serves on the UNMC Chancellor's Council and the Nebraska Medicine's Senior Leadership Team, the two most senior and responsible cabinets of the the academic and the clinical enterprise. A new $323 M Buffett Cancer Center (625,000 gsf) will open in 2017 integrating cancer research and care in one facility and provide ample room FPBCC growth. Since the last review, the FPBCC enhanced interdisciplinary research collaborations by providing support for recruitment of 30 new Members (including the co-leaders of the GICP and the Director of the Bioinformatics Shared Resource), for enhancements to shared research facilities, and for pilot funding for collaborative multidisciplinary research projects. The FPBCC has a robust track record of transdisciplinary cancer research and strong evidence of collaborations bridging all of the Research Programs. Buffett Cancer Center research has resulted in 1409 publications of which 23% are inter-programmatic collaborations, 23% are intra-programmatic collaborations and 9% are both. FPBCC externally funded cancer research portfolio which currently exceeds $34.3 M annually in peer-reviewed support (> 46% NCI) demonstrates university-wide transdisciplinary cancer research collaborations by Buffett Cancer Center Members focused on resolving cancer-related problems.