UECC ANIMAL FACILITY IMPROVEMENT GRANT

描述（由申请人提供）： 内布拉斯加大学医学中心（UNMC）致力于追求动物研究的卓越标准。保持实验动物护理评估和认证协会（AAALAC）的认证是UNMC用来衡量这一目标实现情况的手段之一。比较医学（CM）于2001年8月1日重组为目前的配置，以巩固和集中所有生物医学动物研究和教学的动物护理计划在UNMC校园和1校外位置。CM支持动物护理计划，包括5个独立的动物设施和3个专门的手术设施在奥马哈校园和1个校外位置，并支持动物研究的4所学院，1所学校，2个研究所，9个中心和研究生院的教师。在2001-02财政年度，CM为超过82名主要研究者提供了超过475份动物方案的动物资源服务。UNMC校园的赠款总额为5080万美元，其中包括NIH的2780万美元资金，比过去五年增加了107%。联合国监测委员会的目标是在2005年左右每年获得1亿美元的研究经费。在2002-2003财政年度第二季度，联合国监测委员会收到了1 000万美元的联邦研究赠款。UNMC大约99.9%的动物使用发生在主校区。约16，952平方米英尺目前正在对4230号楼进行翻修，以提供一个校园范围内的远程啮齿动物检疫和再衍生设施，该设施将利用柔性薄膜隔离器进行动物饲养。新的43，821平方米英尺动物设施，在达勒姆研究中心（DRC）正在建设中的伦敦西区的校园。我们在主校区的第二大动物园，Eppley癌症中心（UECC），建于1972年。2001年，研究副校长办公室将UECC动物护理人员、设备和设施整合到CM下。此后，在通风微隔离笼和罩方面进行了大量投资，以增加现有空间中的动物饲养密度。UECC现有的两个高压灭菌器需要更换为更大容量的机器，以适应这种“最先进”的动物护理所发生的巨大变化。由于小型高压灭菌器的限制，不可能增加高密度外壳。这些限制也削弱了屏障住房，如果不在不久的将来纠正，这将破坏我们提供足够的无病毒抗体啮齿动物用于研究的能力。因此，这一设施在联合国军事委员会大院中的翻修优先次序最高。本提案将提供与翻修有关的信息，项目完成后，联合国监测委员会将能够为UECC的研究动物提供数量和质量更好的动物饲养。

DESCRIPTION (provided by applicant): The University of Nebraska Medical Center (UNMC) is committed to pursue a standard of excellence in animal research. Maintaining accreditation by the Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC) is one of the means used by UNMC to measure accomplishment of this objective. Comparative Medicine (CM) was reorganized to its present configuration on August 1,2001 to consolidate and centralize the animal care program for all biomedical animal research and teaching on the UNMC campus and 1 off-campus location. CM supports animal care programs encompassing 5 separate animal facilities and 3 dedicated surgical facilities on the Omaha campus and 1 off-campus location, and supports animal research for the faculty of 4 colleges, 1 school, 2 institutes, 9 centers and Graduate Studies. In fiscal year 2001-02, CM provided animal resource services to over 82 principal investigators with over 475 animal protocols. Grant awards for the UNMC Campus totaled $50.8M including $27.8M in NIH funding, a 107% increase over the previous five years. UNMC's goal is to obtain an annual total of $100M in research funding around the year of 2005. UNMC received $10M in federal research grants during the second quarter of fiscal year 2002-2003. Approximately 99.9% percent of the animal use at UNMC occurs on the main campus complex. Approximately 16, 952 sq. ft. of space is currently under renovation in building 4230 to provide a campus-wide remote rodent quarantine and re-derivation facility that will utilize flexible film isolators for animal holding. A new 43, 821 sq. ft. animal facility, at Durham Research Center (DRC) is under construction on the West end of the campus. Our second largest vivarium on the main campus, the Eppley Cancer Center (UECC), was built in 1972. The Office of the Vice Chancellor for Research integrated the UECC animal care personnel, equipment, and facilities under CM in 2001. Significant investments in ventilated microisolator caging and hoods have since been made to increase animal housing density in existing space. UECC's two existing autoclaves need to be replaced with larger capacity machines to accommodate the tremendous changes that have occurred in this "state of the art" care available for animals. Additional high-density housing is not possible due to the limitations of the undersized autoclaves. These limitations have also weakened the barrier housing, which undermines our ability to provide enough viral antibody free rodents for research if not corrected in the near future. This facility, therefore, has the highest renovation priority on the UNMC campus. This proposal will provide information relative to this renovation and completion of the project will allow UNMC to provide improved quantity and quality animal housing for research animals at the UECC.