Smart template for prostate biopsy guidance

物理科学公司(PSI)，与布里格姆和妇女的放射科合作， 医院（BWH），建议开发一种双动智能模板，以帮助经会阴靶向前列腺 在磁共振成像（MRI）下进行活检和随后的局部治疗程序- 指导尽管MRI成像在识别前列腺癌方面具有高灵敏度，但不准确的放置 将活检针插入器官的MRI突出区域通常无法确认癌症的存在并导致 重复昂贵的活检和潜在的延迟治疗。PSI/BWH团队开发了一种被动式 网格智能模板技术，能够准确插入活检针并定位到 可疑的前列腺癌组织其临床疗效已在多名患者中得到证实。这 然而，技术需要进一步改进，先进的工程和临床评估，以支持 商业化在这个快速通道计划中，我们建议通过消除 无源网格，可实现无数的进入点，以及针的自动定位和成角。的 成角度的插入将能够避免会阴结构，例如疤痕组织和其它区域， 活检针偏转。还将监测活检过程中的患者移动， 将使用定制算法校正活检针轨迹，以获得准确的活检针 转移到靶癌症病灶。首先评估双动作智能模板， 在会阴动物模型中进行优化，然后利用3 T细胞在人类患者中体内测试其功效。 BWH的MRI扫描仪。

Physical Sciences Inc. (PSI), in collaboration with the Department of Radiology at Brigham and Women’s Hospital (BWH), proposes to develop a double-action Smart Template to aid transperineal targeted prostate biopsies and subsequent focal therapy procedures performed under magnetic resonance imaging (MRI)- guidance. Despite the high sensitivity in identifying prostate cancer with MRI imaging, inaccurate placement of the biopsy needle into the MRI highlighted area of the organ often fails to confirm cancer presence and leads to repeated costly biopsies and potentially delayed treatment. The PSI/BWH team has developed a passive grid Smart Template technology that enables accurate insertion of the biopsy needle and positioning into a suspicious prostate cancer tissue. Its clinical efficacy has already been demonstrated in multiple patients. This technology however requires further improvement, advanced engineering, and clinical evaluation to support commercialization. In this Fast-Track program we propose to further advance the technology by eliminating the passive grid, enabling countless entry points, and automated positioning and angulation of the needle. The angled insertion will enable avoidance of the perineal structures such as scar tissue and other areas that cause deflection of biopsy needle. Patient movement during the biopsy procedures will also be monitored, and the biopsy needle trajectory will be corrected using a custom algorithm for the accurate biopsy needle displacement to the target cancer lesion. The double-action Smart Template will be first evaluated and optimized in perineal animal models, and then its efficacy will be tested in vivo in human patients utilizing a 3T MRI scanner at BWH.