Smart template for prostate biopsy guidance

前列腺活检指导智能模板

• 批准号: 10000931
• 负责人: Jesung Park
• 金额: $ 58.46万
• 依托单位: PHYSICAL SCIENCES, INC
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-01 至 2023-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10000931
• 关键词: Algorithms; Animal Model; Animals; Anogenital region; Area; Autopsy; Biopsy; Businesses; Cancer Detection; Cancer Etiology; Cessation of life; Cicatrix; Clinical; Collaborations; Computers; Custom; Detection; Development; Devices; Early Diagnosis; Engineering; Ensure; Evaluation; Family suidae; Goals; Hospitals; Human; Image; Image Guided Biopsy; Infection; Lesion; Location; Magnetic Resonance Imaging; Malignant Neoplasms; Malignant neoplasm of prostate; Marketing; Measures; Methods; Modeling; Monitor; Morbidity - disease rate; Morphologic artifacts; Motion; Movement; Muscle; Needle biopsy procedure; Needles; Organ; PSA level; Pathology; Patient Schedules; Patients; Phase; Positioning Attribute; Principal Investigator; Procedures; Prostate; Radiology Specialty; Resources; Robotics; Scientist; Screening for Prostate Cancer; Seed Implantation; Severities; Structure; Survival Rate; System; Technology; Tissues; Translating; Transrectal Ultrasound; United States; Woman; base; clinical efficacy; commercialization; cost; design; diagnostic accuracy; image guided; improved; in vivo Model; in vivo evaluation; men; multidisciplinary; physical science; procedure cost; programs; prostate biopsy; prototype; pubis bone structure; research clinical testing; screening; success

Physical Sciences Inc. (PSI), in collaboration with the Department of Radiology at Brigham and Women’s Hospital (BWH), proposes to develop a double-action Smart Template to aid transperineal targeted prostate biopsies and subsequent focal therapy procedures performed under magnetic resonance imaging (MRI)- guidance. Despite the high sensitivity in identifying prostate cancer with MRI imaging, inaccurate placement of the biopsy needle into the MRI highlighted area of the organ often fails to confirm cancer presence and leads to repeated costly biopsies and potentially delayed treatment. The PSI/BWH team has developed a passive grid Smart Template technology that enables accurate insertion of the biopsy needle and positioning into a suspicious prostate cancer tissue. Its clinical efficacy has already been demonstrated in multiple patients. This technology however requires further improvement, advanced engineering, and clinical evaluation to support commercialization. In this Fast-Track program we propose to further advance the technology by eliminating the passive grid, enabling countless entry points, and automated positioning and angulation of the needle. The angled insertion will enable avoidance of the perineal structures such as scar tissue and other areas that cause deflection of biopsy needle. Patient movement during the biopsy procedures will also be monitored, and the biopsy needle trajectory will be corrected using a custom algorithm for the accurate biopsy needle displacement to the target cancer lesion. The double-action Smart Template will be first evaluated and optimized in perineal animal models, and then its efficacy will be tested in vivo in human patients utilizing a 3T MRI scanner at BWH.

物理科学公司 (PSI) 与布莱根妇女医院放射科合作 医院 (BWH) 提议开发一种双作用智能模板，以帮助经会阴靶向前列腺 在磁共振成像（MRI）下进行活检和随后的局部治疗程序- 指导。尽管 MRI 成像识别前列腺癌的灵敏度很高，但前列腺癌的放置不准确 将活检针插入器官的 MRI 突出区域通常无法确认癌症的存在和线索 重复昂贵的活检和可能延迟的治疗。 PSI/BWH 团队开发了一种被动式 网格智能模板技术，能够准确插入活检针并定位到 可疑的前列腺癌组织。其临床疗效已在多名患者身上得到证实。这 然而，技术需要进一步改进、先进的工程和临床评估来支持 商业化。在这个快速通道计划中，我们建议通过消除 无源网格，可实现无数的入口点以及针的自动定位和角度。这 成角度插入将能够避免会阴结构，例如疤痕组织和其他导致 活检针偏转。活检过程中患者的活动也将受到监测，并且 活检针轨迹将使用定制算法进行校正，以获得准确的活检针 转移到目标癌症病灶。双动智能模板将首先被评估并 在会阴动物模型中进行优化，然后使用 3T 在人类患者体内测试其功效 BWH 的 MRI 扫描仪。