Core D - Energy Balance and Body Composition Core

核心 D - 能量平衡和身体成分核心

基本信息

批准号：
9982358
负责人：
Changcheng Zhou
金额：
$ 19.13万
依托单位：
UNIVERSITY OF KENTUCKY
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-08-01 至 2023-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9982358
关键词：
Acclimatization Adipose tissue Animals Area Blood Pressure Body Composition Body Water Body Weight Cardiovascular Diseases Cells Chronic Collaborations Communities Conscious Consultations Coupled Data Diabetes Mellitus Diet Eating Energy Metabolism Equipment Exercise Experimental Models Fatty acid glycerol esters Fees Food Energy Fostering Funding Genetic Genome Growth Health care facility Human Resources Indirect Calorimetry Individual Institution Intervention Kentucky Laboratories Longitudinal Studies Magnetic Resonance Imaging Malignant Neoplasms Measurement Metabolism Methods Modernization Mus Neurodegenerative Disorders Obese Mice Obesity Obesity Epidemic Obesity associated disease Phase Physical activity Pilot Projects Principal Investigator Proteins Recommendation Regulation Research Research Design Research Personnel Resources Running Services Standardization Structure Study models System Therapeutic Thinness Time Tissues Training United States National Institutes of Health Water consumption Weight animal care base cardiovascular risk factor energy balance experience feeding health disparity improved insight mid-career faculty obesity development operation outreach program programs time use

项目摘要

The Energy Balance and Body Composition Core (Core D) serves investigators across the institution to quantify energy balance and body composition in mice. Accurate quantification of these parameters is essential for studies focused on obesity, with wide-spread capabilities for metabolism-related studies. The core houses 24 LabMaster TSE® chambers that quantify food and water intake, physical activity and indirect calorimetry in mice, a common model for studies focused on the effect of diet or genetics on the development of obesity. The Core also houses an EchoMRI® to quantify lean and fat mass and total body water in conscious mice. Both systems allow for non-invasive longitudinal assessment of energy balance and body composition. Competent core staff maintain and oversee the use of the LabMaster TSE® system and train personnel in use of the EchoMRI®. Core Directors assist in study design and data handling and analysis. Over 50 Principal Investigators use the LabMaster TSE® system annually for studies on >700 mice/year, while the EchoMRI® is used by more than 25 laboratories annually. These systems are not duplicated at the institution or within the Commonwealth, and are vital to our ability to reduce the epidemic of obesity in Kentucky. In Phase III of the program, we will broaden our focus to include obesity as a risk factor for cardiovascular diseases, diabetes, cancer and neurodegenerative diseases. This will increase use of the system to support an anticipated larger user base with targeted growth within these areas across the institution. We will also purchase a new system, from institutional support, that will markedly expand capabilities of this core in quantifying energy metabolism in mice. Also, during Phase III of the program the core for this system, including all equipment, will be relocated to a modern animal care facility within a new research building that is dedicated to the study of these health disparities. We anticipate that this core will transition to self-sustaining capacity over the course of Phase III support of the COCVD.

能量平衡和身体成分核心（核心D）为整个机构的调查人员提供服务量化小鼠的能量平衡和身体成分。这些参数的准确量化是对于重点是肥胖的研究至关重要，具有与代谢相关的研究的广泛能力。核心房屋24个LabmasterTSE®腔室，可量化食物和水的摄入量，体育锻炼和间接小鼠的量热法，这是一种集中于饮食或遗传学对发展的影响的常见研究模型肥胖。核心还包含一个eChomri®，以量化瘦肉和脂肪质量以及全身水有意识的老鼠。这两个系统都允许对能量平衡和身体的非侵入性纵向评估作品。有能力的核心人员维护和监督LabmasterTSE®系统的使用和训练使用Echomri®的人员。核心主管协助研究设计和数据处理和分析。超过50名主要研究人员每年使用LabmasterTSE®系统进行> 700只鼠标的研究，而 Echomri®每年25个以上的实验室使用。这些系统在机构或英联邦内部，对我们减少肥胖流行的能力至关重要肯塔基。在该计划的第三阶段中，我们将扩大重点，将肥胖作为危险因素包括心血管疾病，糖尿病，癌症和神经退行性疾病。这将增加使用的使用支持预期的较大用户群，并在这些领域内有针对性增长的系统机构。我们还将从机构支持中购买一个新系统，该系统将显着扩展该核心在量化小鼠能量代谢方面的能力。同样，在该计划的第三阶段期间该系统的核心，包括所有设备，将被搬迁到新的动物护理设施中致力于研究这些健康差异的研究大楼。我们预计这个核心将会在COCVD的第三阶段支持过程中，过渡到自我维持的能力。