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Cerebellar Transcranial Direct Current Stimulation to Augment Chronic Aphasia Treatment

小脑经颅直流电刺激增强慢性失语症治疗

基本信息

批准号：
9982292
负责人：
Rajani Sebastian
金额：
$ 23.63万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-08-01 至 2022-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9982292
关键词：
Affect Aftercare Anodes Aphasia Area Behavioral Brain Cathodes Cerebellum Chronic Clinical Management Clinical Research Cognition Cognitive Communication Communities Complex Coupled Cross-Over Trials Data Double-Blind Method Financial compensation Functional Magnetic Resonance Imaging Goals Homologous Gene Human Individual Interpersonal Relations Intervention Language Language Development Language Disorders Language Therapy Left Lesion Life Mentors Mission Names National Institute on Deafness and Other Communication Disorders Neuronal Plasticity Outcome Parietal Participant Pattern Performance Phase Randomized Recovery Rehabilitation therapy Research Research Personnel Research Proposals Residual state Rest Stroke Structure Structure-Activity Relationship Techniques Testing Therapeutic Training Work chronic stroke cognitive function computerized design disability effectiveness evaluation improved insight language outcome neuroimaging neuroregulation novel strategies post stroke recruit relating to nervous system skills stroke survivor stroke-induced aphasia treatment comparison trial design

项目摘要

Project Summary Aphasia is one of the leading causes of disability following stroke. Individuals with post-stroke aphasia are left with some degree of chronic deficit for which current rehabilitative treatments are variably effective. A small growing body of evidence suggests that transcranial direct current stimulation (tDCS) may be useful for enhancing the effects of behavioral aphasia treatment. The candidate proposes a comprehensive training plan that seeks to expand her understanding of brain plasticity associated with tDCS aphasia treatment by providing extensive training in neuromodulatory technique, structure–function relationships in chronic aphasia, behavioral aphasia treatment, cerebellar mechanisms of cognitive functions, and advanced neuroimaging techniques. This research proposal will permit the candidate to apply these skills in understanding language recovery and treatment of naming deficits in chronic stroke survivors with aphasia with large lesions. Specifically, this proposal aims to study the effects of right cerebellar tDCS on naming and functional connectivity changes of the language network in chronic stroke survivors with aphasia. During the mentored phase, the candidate will evaluate the benefits of tDCS + computerized naming therapy compared to computerized naming therapy alone on trained and untrained items immediately after intervention and through 2 months post-therapy. This will allow us to evaluate the potential benefits and sustainability of cerebellar tDCS in stroke survivors with large lesions and the generalization of trained items to untrained items. During the independent phase, the candidate will examine the topography of network modulation by right cerebellar tDCS in individuals with chronic aphasia by using resting-state fMRI. This will enable us to evaluate the polarity- specific changes in brain network dynamics induced by cerebellar tDCS to provide a plausible mechanistic account of neuroplasticity and explain behavioral changes that are modulated by cerebellar tDCS in aphasia.

项目摘要失语症是中风后残疾的主要原因之一。中风后失语症患者留下了某种程度的慢性缺陷，目前的康复治疗对这些缺陷非常有效。一越来越多的证据表明，经颅直流电刺激（tDCS）可能有助于增强行为性失语症治疗的效果。候选人提出全面的培训计划该研究旨在通过提供以下内容来扩大她对与tDCS失语症治疗相关的大脑可塑性的理解：在神经调节技术，慢性失语症的结构-功能关系，行为性失语症治疗、认知功能的小脑机制和高级神经影像学技术.这项研究计划将允许候选人应用这些技能在理解语言大病灶失语症慢性卒中幸存者命名缺陷的恢复和治疗。具体来说，这项建议旨在研究右侧小脑tDCS对命名和功能的影响。慢性卒中失语症幸存者语言网络的连通性改变在指导期间，阶段，候选人将评估tDCS +计算机命名疗法与在干预后立即对训练和未训练的项目进行计算机命名治疗，并通过治疗后2个月。这将使我们能够评估小脑tDCS的潜在益处和可持续性在大病灶的中风幸存者和训练项目的泛化到未经训练的项目。期间独立阶段，考生将检查右侧小脑tDCS的网络调制拓扑在慢性失语症患者中进行的研究。我们就能评估极性- 小脑tDCS诱导的脑网络动力学的特定变化，以提供合理的机制说明神经可塑性和解释失语症中小脑tDCS调节的行为变化。