MRI-Compatible Robot for Real-Time Image-Guided Stereotactic Neurosurgical Procedures: A Novel Platform Technology

用于实时图像引导立体定向神经外科手术的 MRI 兼容机器人：一种新颖的平台技术

• 批准号: 10181508
• 负责人: Reza Monfaredi
• 金额: $ 49.79万
• 依托单位: CHILDREN'S RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-20 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10181508
• 关键词: Ablation; Address; Anesthesia procedures; Area; Arthroscopy; Biopsy; Brain; Brain Neoplasms; Brain imaging; Cadaver; Cephalic; Child; Childhood; Clinical; Clinical Research; Complex; Complication; Consumption; Development; Devices; Diagnostic Procedure; Disease; Ensure; Epilepsy; Freedom; Funding; Goals; Head; Hemorrhage; Hospitals; Hour; Human; Image; Image-Guided Surgery; Injections; Intervention; Logistics; Magnetic Resonance Imaging; Malignant Neoplasms; Manuals; Maps; Medical Device; Medical center; Methods; Morbidity - disease rate; Needle biopsy procedure; Needles; Neoplasm Metastasis; Neurosurgeon; Neurosurgical Procedures; Operative Surgical Procedures; Outcome; Pain; Parkinson Disease; Patient Care; Patients; Pediatric Hospitals; Phase; Planning Techniques; Positioning Attribute; Postoperative Hemorrhage; Procedures; Research; Rewards; Risk; Robot; Robotics; Safety; Structure; Supervision; Surgeon; System; Techniques; Technology; Testing; Time; United States; United States National Institutes of Health; Validation; Visualization; Work; X-Ray Computed Tomography; base; blind; clinical development; cost; cranium; design; design and construction; experience; image guided; image guided intervention; imaging modality; improved; instrument; interest; mortality; neurosurgery; novel; operation; procedure safety; real-time images; robotic system; soft tissue; tumor

Project Summary/Abstract This project aims to develop a novel MRI-compatible robotic system with an integrated imaging coil array to enable in-bore real-time interventional procedures, improve the targeting accuracy, shorten the pre-operative path planning time, and intra-operative surgery time. Currently, neurosurgeons often use pre-operative MRI to plan the path manually and place the instrument in the brain outside of the MRI room either manually using a passive stereotactic frame, or by using non-MRI compatible robots such as ROSA. Performing neurosurgical procedures using real-time MRI-guidance requires an enabling technology for in-bore interventions. Although an MRI-compatible commercial device has been recently introduced, ClearPoint, for real-time MRI-guided targeting, it is passive and thus requires time consuming manual adjustment. It is also not appropriate for multi- target application as it is locally mounted on the skull. For tumor biopsy and ablation, path planning currently requires the neurosurgeon to perform extensive manual preoperative planning which can require one hour or more. Despite extensive pre-planning, intra-operative re-planning is sometimes required once the skull is opened. Lastly, current imaging head coils have been designed specifically for diagnostic procedures, encompassing the patient’s head and limiting access to the surgical area. Consequently, current procedures are time-intensive, especially for multi-target procedures. There are no existing medical device technologies that can address all the major neurosurgery challenges of: 1) lengthy blind procedure time for single-/multi-target procedures, 2) limited brain access due to the MR imaging coil, and 3) extensive manual path planning. We propose to develop an MRI-compatible and low-profile novel robotic system with embedded movable coil array for real-time in-bore application featured with automatic path planning techniques. The specific aims of the proposed research are to (1) Design, construct, and test an MRI-compatible robot with an automatic path planner, (2) Develop an embedded MR coil array, and (3) Integrate the system components and evaluate the system accuracy. The successful completion of the proposed project will provide the necessary technical feasibility and workflow validation information to support development of clinically viable system for human trial in the next phase.

项目总结/文摘