Pilot Project Program

试点项目计划

• 批准号: 10182737
• 负责人: KRISTINE L WILLETT
• 金额: $ 25.55万
• 依托单位: UNIVERSITY OF MISSISSIPPI
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-15 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10182737
• 关键词: Address; Applications Grants; Area; Award; Basic Science; Benchmarking; Budgets; Centers of Research Excellence; Clinical Research; Clinical Sciences; Collaborations; Coupled; Data; Development; Enrollment; Ensure; Extramural Activities; Feedback; Foundations; Goals; Grant; Industrialization; Infrastructure; Investments; Lead; Mentors; Mississippi; National Institute of General Medical Sciences; Natural Products; Neuraxis; Neurosciences; Peer Review; Pharmacy Schools; Phase; Pilot Projects; Process; Program Evaluation; Program Reviews; Publications; Recommendation; Reporting; Research; Research Personnel; Review Committee; Science; Scientist; Secure; Shark; Study Section; Technology; Time; Translating; Translational Research; United States National Institutes of Health; Universities; Vision; Writing; base; clinical center; clinical practice; commercialization; data acquisition; design; experience; insight; member; multidisciplinary; programs; research clinical testing; success

PROJECT SUMMARY/ABSTRACT The Center of Research Excellence in Natural Products Neuroscience (CORE-NPN) at The University of Mississippi School of Pharmacy (UM), initiated ten years ago through a COBRE grant, has developed a multidisciplinary team committed to evaluating the effects of natural products on the central nervous system (CNS). The Pilot Project Program will continue in Phase III in much the same manner as in the previous two phases and will include three areas of support: 1) basic science research, which is the pipe-line for developing new data for grant applications and publications; 2) translational research, which, in conjunction with the UM Center for Clinical and Translational Science (CCTS) will facilitate the clinical evaluation of lead compounds discovered by CORE-NPN scientists; and 3) entrepreneurial research, which will allow scientists to advance their commercial discoveries with support from the UM Division of Technology management team. The Specific Aims to accomplish our goals are: Specific Aim 1: To advance the infrastructure of developmental Pilot Project Programs cultivated during Phase I and II that engage in basic, translational, and entrepreneurial research at the interface of natural products and neuroscience. This will ensure that investigators have the opportunity to obtain new data that are critical for competitive grant applications, translate their research findings to clinical studies, and to advance the commercialization of discoveries. Specific Aim 2: To enhance the rigorous assessment of the science conducted in the Pilot Project Program and promote peer-reviewed publications, presentations, and competitive grant applications. Applicants will be invited to submit a cover page and a Specific Aims page for their project which will be reviewed by the PPP Review Committee. Following this review, eight applicants will be invited to submit an R03-style proposal which will be further evaluated and proposers will present their proposals (Shark-Tank-COBRE) to the review committee, who will seek clarifications and provide guidance. Applicants will then submit a revised A-1 like proposal, addressing concerns raised which will then be forwarded to the EAC for final review and recommendation. Pending approval by the EAC, proposals will be submitted to the NIGMS for review and final approval. Outside reviewers with expertise on the subject may be invited, if necessary, for recommendations. Recipients will be required to deliver an Ignite-COBRE-Talk every quarter on their progress; additionally, recipients will be expected to present their research findings to the EAC during their annual review of our program. Specific Aim 3: To advance an infrastructure of developmental programs that include formal mentoring of investigators enrolled in the Pilot Project Program. This is the cornerstone of the success the PPP experienced in Phase I and II and will continue in Phase III. Each PPP PI will be assigned at least one mentor to help guide the young scientist's project. The mentor will be selected based on their expertise and the needs of the investigator. PPP evaluation metrics and benchmarks will be assessed and reported to the EAC biannually.

项目摘要/摘要 大学天然产品卓越研究中心神经科学（Core-NPN） 密西西比州药学院（UM）于十年前通过毛刺赠款启动，开发了一个 多学科团队致力于评估天然产品对中枢神经系统的影响 （CNS）。试点项目计划将以与前两个相同的方式继续以III阶段继续 阶段，将包括三个支持领域：1）基础科学研究，这是开发的管道 赠款应用程序和出版物的新数据； 2）转化研究，与UM结合 临床和转化科学中心（CCTS）将促进铅化合物的临床评估 由核心-NPN科学家发现； 3）企业家研究，这将使科学家能够晋升 他们的商业发现在UM技术管理团队的支持下。具体 实现我们的目标的目的是：特定目标1：推进发展试点项目的基础设施 在第一阶段和第二阶段培养的计划，从事基础，转化和企业家研究 天然产品和神经科学的界面。这将确保调查人员有机会 获取对竞争性赠款应用程序至关重要的新数据，将其研究结果转化为临床 研究，并推进发现的商业化。特定目标2：增强严格的 对试点项目计划进行的科学的评估，并促进经同行评审的出版物， 演示文稿和竞争性赠款申请。将邀请申请人提交封面和一个 其项目的具体目标页面将由​​PPP审查委员会审查。在此评论之后， 将邀请八名申请人提交R03风格的提案，并将进一步评估建议者 将向审查委员会提出他们的建议（鲨鱼tank-cobre），后者将寻求澄清和 提供指导。然后，申请人将提交经修订的A-1等提案，以解决提出的问题，这将 然后将其转发给EAC进行最终审查和建议。 EAC的批准，提案 将提交给Nigms进行审查和最终批准。外部评论者具有该主题专业知识 如有必要，可以邀请建议。将需要接收者提供点火式曲折 每个季度的进步；此外，希望接受者将其研究结果提交给 EAC在对我们计划的年度审查期间。特定目标3：推进发展基础设施 计划的计划包括对试点项目计划入学的调查人员的正式指导。这是 PPP在第一阶段和第二阶段经历的成功的基石将继续在第三阶段。每个PPP PI 将至少分配一位导师，以帮助指导年轻科学家的项目。导师将被选中 基于他们的专业知识和调查员的需求。 PPP评估指标和基准将是 每两年一次评估并报告给EAC。