Pilot Project Program

项目摘要/摘要 加州大学天然产物神经科学卓越研究中心(CORE-NPN) 密西西比州药学院(UM)，十年前通过科布雷赠款发起，已经开发出一种 致力于评估天然产品对中枢神经系统影响的多学科团队 (CNS)。试点项目方案将以与前两个阶段大致相同的方式在第三阶段继续 它将包括三个方面的支持：1)基础科学研究，这是发展的管道 赠款申请和出版物的新数据；2)翻译研究，与密歇根大学合作 临床和翻译科学中心(CCTS)将促进先导化合物的临床评估 由CORE-NPN科学家发现；以及3)创业研究，这将使科学家 他们的商业发现得到了密歇根大学技术部门管理团队的支持。具体的 我们的目标是：具体目标1：推进发展试点项目的基础设施 在第一阶段和第二阶段培养的计划，这些计划从事基础、翻译和创业研究， 天然产物和神经科学的接口。这将确保调查人员有机会 获得对竞争性拨款申请至关重要的新数据，将他们的研究成果转化为临床 研究，并推进发现的商业化。具体目标二：提升严谨 对试点项目方案中进行的科学评估，并促进同行评议的出版物； 演示文稿和竞争性拨款申请。申请者将被邀请提交一个封面和一个 他们的项目的具体目标页面，将由PPP审查委员会审查。在这次审查之后， 8名申请者将被邀请提交一份R03风格的建议书，该建议书将接受进一步的评估和建议书 将向审查委员会提交他们的建议(Shark-Tank-Cobre)，审查委员会将要求澄清并 提供指导。申请者随后将提交修订后的A-1类提案，以解决提出的关切，这将 然后转交选管会作最后审查和建议。有待选管会批准的建议 将提交给NIGMS进行审查和最终批准。具有该主题专业知识的外部评审员 如有必要，可邀请其提供建议。收件人将被要求发表一篇Ignite-Cobre-Talk 每季度介绍他们的进展；此外，获奖者将被要求向 EAC在他们对我们的计划的年度审查中。具体目标3：推进可持续发展基础设施 包括对参加试点项目计划的调查人员进行正式指导的计划。这是 公私合作伙伴关系在第一阶段和第二阶段取得成功的基石，并将在第三阶段继续。 将被指派至少一名导师来帮助指导这位年轻科学家的项目。导师将被挑选出来 根据他们的专业知识和调查员的需要。购买力平价评估指标和基准将是 每两年评估一次并向选管会汇报。

PROJECT SUMMARY/ABSTRACT The Center of Research Excellence in Natural Products Neuroscience (CORE-NPN) at The University of Mississippi School of Pharmacy (UM), initiated ten years ago through a COBRE grant, has developed a multidisciplinary team committed to evaluating the effects of natural products on the central nervous system (CNS). The Pilot Project Program will continue in Phase III in much the same manner as in the previous two phases and will include three areas of support: 1) basic science research, which is the pipe-line for developing new data for grant applications and publications; 2) translational research, which, in conjunction with the UM Center for Clinical and Translational Science (CCTS) will facilitate the clinical evaluation of lead compounds discovered by CORE-NPN scientists; and 3) entrepreneurial research, which will allow scientists to advance their commercial discoveries with support from the UM Division of Technology management team. The Specific Aims to accomplish our goals are: Specific Aim 1: To advance the infrastructure of developmental Pilot Project Programs cultivated during Phase I and II that engage in basic, translational, and entrepreneurial research at the interface of natural products and neuroscience. This will ensure that investigators have the opportunity to obtain new data that are critical for competitive grant applications, translate their research findings to clinical studies, and to advance the commercialization of discoveries. Specific Aim 2: To enhance the rigorous assessment of the science conducted in the Pilot Project Program and promote peer-reviewed publications, presentations, and competitive grant applications. Applicants will be invited to submit a cover page and a Specific Aims page for their project which will be reviewed by the PPP Review Committee. Following this review, eight applicants will be invited to submit an R03-style proposal which will be further evaluated and proposers will present their proposals (Shark-Tank-COBRE) to the review committee, who will seek clarifications and provide guidance. Applicants will then submit a revised A-1 like proposal, addressing concerns raised which will then be forwarded to the EAC for final review and recommendation. Pending approval by the EAC, proposals will be submitted to the NIGMS for review and final approval. Outside reviewers with expertise on the subject may be invited, if necessary, for recommendations. Recipients will be required to deliver an Ignite-COBRE-Talk every quarter on their progress; additionally, recipients will be expected to present their research findings to the EAC during their annual review of our program. Specific Aim 3: To advance an infrastructure of developmental programs that include formal mentoring of investigators enrolled in the Pilot Project Program. This is the cornerstone of the success the PPP experienced in Phase I and II and will continue in Phase III. Each PPP PI will be assigned at least one mentor to help guide the young scientist's project. The mentor will be selected based on their expertise and the needs of the investigator. PPP evaluation metrics and benchmarks will be assessed and reported to the EAC biannually.