Pilot Project Program

试点项目计划

• 批准号: 10182737
• 负责人: KRISTINE L WILLETT
• 金额: $ 25.55万
• 依托单位: UNIVERSITY OF MISSISSIPPI
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-15 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10182737
• 关键词: Address; Applications Grants; Area; Award; Basic Science; Benchmarking; Budgets; Centers of Research Excellence; Clinical Research; Clinical Sciences; Collaborations; Coupled; Data; Development; Enrollment; Ensure; Extramural Activities; Feedback; Foundations; Goals; Grant; Industrialization; Infrastructure; Investments; Lead; Mentors; Mississippi; National Institute of General Medical Sciences; Natural Products; Neuraxis; Neurosciences; Peer Review; Pharmacy Schools; Phase; Pilot Projects; Process; Program Evaluation; Program Reviews; Publications; Recommendation; Reporting; Research; Research Personnel; Review Committee; Science; Scientist; Secure; Shark; Study Section; Technology; Time; Translating; Translational Research; United States National Institutes of Health; Universities; Vision; Writing; base; clinical center; clinical practice; commercialization; data acquisition; design; experience; insight; member; multidisciplinary; programs; research clinical testing; success

PROJECT SUMMARY/ABSTRACT The Center of Research Excellence in Natural Products Neuroscience (CORE-NPN) at The University of Mississippi School of Pharmacy (UM), initiated ten years ago through a COBRE grant, has developed a multidisciplinary team committed to evaluating the effects of natural products on the central nervous system (CNS). The Pilot Project Program will continue in Phase III in much the same manner as in the previous two phases and will include three areas of support: 1) basic science research, which is the pipe-line for developing new data for grant applications and publications; 2) translational research, which, in conjunction with the UM Center for Clinical and Translational Science (CCTS) will facilitate the clinical evaluation of lead compounds discovered by CORE-NPN scientists; and 3) entrepreneurial research, which will allow scientists to advance their commercial discoveries with support from the UM Division of Technology management team. The Specific Aims to accomplish our goals are: Specific Aim 1: To advance the infrastructure of developmental Pilot Project Programs cultivated during Phase I and II that engage in basic, translational, and entrepreneurial research at the interface of natural products and neuroscience. This will ensure that investigators have the opportunity to obtain new data that are critical for competitive grant applications, translate their research findings to clinical studies, and to advance the commercialization of discoveries. Specific Aim 2: To enhance the rigorous assessment of the science conducted in the Pilot Project Program and promote peer-reviewed publications, presentations, and competitive grant applications. Applicants will be invited to submit a cover page and a Specific Aims page for their project which will be reviewed by the PPP Review Committee. Following this review, eight applicants will be invited to submit an R03-style proposal which will be further evaluated and proposers will present their proposals (Shark-Tank-COBRE) to the review committee, who will seek clarifications and provide guidance. Applicants will then submit a revised A-1 like proposal, addressing concerns raised which will then be forwarded to the EAC for final review and recommendation. Pending approval by the EAC, proposals will be submitted to the NIGMS for review and final approval. Outside reviewers with expertise on the subject may be invited, if necessary, for recommendations. Recipients will be required to deliver an Ignite-COBRE-Talk every quarter on their progress; additionally, recipients will be expected to present their research findings to the EAC during their annual review of our program. Specific Aim 3: To advance an infrastructure of developmental programs that include formal mentoring of investigators enrolled in the Pilot Project Program. This is the cornerstone of the success the PPP experienced in Phase I and II and will continue in Phase III. Each PPP PI will be assigned at least one mentor to help guide the young scientist's project. The mentor will be selected based on their expertise and the needs of the investigator. PPP evaluation metrics and benchmarks will be assessed and reported to the EAC biannually.

项目总结/摘要 自然产品神经科学卓越研究中心（CORE-NPN） 密西西比药学院（UM），十年前通过COBRE赠款发起，已经开发了一种 致力于评估天然产品对中枢神经系统的影响的多学科团队 （CNS）。试点项目计划将在第三阶段继续进行，其方式与前两个阶段大致相同 分三个阶段，包括三个支持领域：1）基础科学研究，这是发展的管道 资助申请和出版物的新数据; 2）转化研究，与UM一起 临床和转化科学中心（CCTS）将促进先导化合物的临床评价 由CORE-NPN科学家发现; 3）创业研究，这将使科学家能够推进 他们的商业发现与技术管理团队的UM部门的支持。具体 具体目标1：推进发展试点项目的基础设施建设 在第一阶段和第二阶段培养的项目，从事基础，转化和创业研究， 天然产物和神经科学的界面。这将确保调查人员有机会 获得对竞争性资助申请至关重要的新数据，将他们的研究成果转化为临床应用， 研究，并促进发现的商业化。具体目标2：加强 评估试点项目计划中进行的科学研究，并促进同行评审的出版物， 演讲和竞争性赠款申请。申请人将被邀请提交封面和 他们的项目将由PPP审查委员会审查的具体目标页面。在这次审查之后， 八个申请者将被邀请提交一份R 03风格的建议书，该建议书将被进一步评估， 将向审查委员会提出他们的建议（鲨鱼坦克-COBRE），审查委员会将寻求澄清， 提供指导。然后，申请人将提交一份修订后的A-1类提案，解决提出的问题， 然后提交给选管会进行最终审查并提出建议。在选举管理委员会批准之前， 将提交给NIGMS进行审查和最终批准。具有该主题专门知识的外部审查员 如有必要，可请其提出建议。收件人将被要求提供一个点燃-COBRE-谈 每个季度的进展情况;此外，获奖者将被要求向 EAC在我们的计划的年度审查期间。具体目标3：推进发展的基础设施 包括对参加试点项目计划的研究者进行正式指导的计划。这是 这是公私伙伴关系在第一和第二阶段取得成功的基石，并将在第三阶段继续下去。每个PPP PI 将被指派至少一名导师来帮助指导年轻科学家的项目。导师将被选中 根据他们的专业知识和调查员的需要。PPP评估指标和基准将 每半年进行一次评估并向EAC报告。