Proprioceptive Coding of Jaw Movement during Orofacial Behavior

项目摘要 将感觉信息与运动指令相结合，可以使运动具有适应性。例如, 许多对生存至关重要的口腔面部行为(咀嚼、喝酒、呼吸等)涉及更新移动 基于与物体的相互作用的轨迹(例如，将咀嚼模式与食物材料特性相匹配)。 本体感受器是提供身体位置信息的感官传入，可能起着至关重要的作用 在这一过程中的角色。然而，鉴于大多数过去本体感受器记录不是在清醒状态下执行的 对于动物来说，缺乏对清醒环境中本体感受器运动编码的清楚理解。这个项目 将靶向和记录来自小鼠下颌神经本体感受器(位于后脑中脑) 并测试三叉神经(MeV)核在口面部行为中的功能作用。目标1将描述 小鼠MeV传入的功能组织，同时开发针对这一群体的遗传工具。目标 2将在高分辨率运动跟踪期间记录来自行为动物的MeV神经元。使用这个 数据集，将建立一个系统的定量模型的MeV神经元活动在自愿口腔面部 行为。目的3将干扰MeV神经元的活动，以了解MeV神经元在口面部的功能作用 行为。该项目的完成将包括体内生理学、行为分析、 和系统/计算技术。这项培训将利用丰富的神经回路和 系统研究，特别是基于实验室在感觉和运动系统神经科学方面的专业知识 赞助商和共同赞助商。总的来说，拟议的项目将定义信息编码属性 口腔面部运动过程中的本体感受器，并探讨这一信息在口腔运动中的功能作用 行为。这些结果可以为临床上所见的颌骨运动问题的治疗策略提供参考。 戴假牙患者、颞下颌关节紊乱病等)。更广泛地说，这项工作可以提供新颖的 对本体感觉信息在运动控制中的作用的洞察，这对 对健康和病理情况下的运动有基本的了解。

Project Summary Integration of sensory information with motor commands allows movement to be adaptable. For example, many survival-critical orofacial behaviors (chewing, drinking, breathing, etc.) involve updating movement trajectories based on interaction with objects (e.g. matching chewing patterns to food material properties). Proprioceptors, which are sensory afferents that provide information about body position, likely play critical roles in this process. However, given that most past recording of proprioceptors was not performed in awake animals, a clear understanding of proprioceptor movement coding in the awake context is lacking. This project will target and record from mouse jaw-innervating proprioceptors (which lie in the hindbrain mesencephalic trigeminal (MeV) nucleus) during orofacial behavior and test their functional role. Aim 1 will characterize the functional organization of mouse MeV afferents while developing genetic tools for targeting this population. Aim 2 will record from MeV neurons in behaving animals during high-resolution movement tracking. Using this dataset, a systematic quantitative model will be built for MeV neuron activity during voluntary orofacial behavior. Aim 3 will perturb MeV neuron activity to understand the functional role of MeV neurons in orofacial behavior. Completion of this project will involve high-level training in in vivo physiology, behavioral analysis, and systems/computational techniques. This training will draw upon a rich environment for neural circuit and systems research, especially based on the expertise in sensory and motor systems neuroscience in the labs of the Sponsor and Co-Sponsor. Collectively, the proposed project will define the information coding properties of proprioceptors during orofacial movement as well as probe the functional role of this information during behavior. These results could inform strategies for treatment of jaw motor problems seen in the clinic (i.e. denture-wearing patients, temporomandibular joint disorders, etc.). More broadly, this work can provide novel insights into the role of proprioceptive information in motor control, which has wide-ranging implications for the fundamental understanding of movement in healthy and pathological contexts.