Proprioceptive Coding of Jaw Movement during Orofacial Behavior

项目摘要 将感觉信息与运动指令相结合，可以使运动具有适应性。为 例如，许多对生存至关重要的口腔面部行为(咀嚼、饮酒、呼吸等)涉及到 基于与对象的交互(例如匹配咀嚼)更新移动轨迹 从图案到食品材料属性)。本体感受器，这是一种感觉传入，提供 有关身体位置的信息，可能在这一过程中起着关键作用。然而，鉴于 过去大多数本体感受器的记录都不是在清醒的动物中进行的，这是一个明显的 缺乏对清醒环境中本体感受器运动编码的理解。这个项目 将从小鼠下颌神经本体感受器(位于后脑)进行靶向和记录 并测试它们在口面部行为中的功能作用。 目标1将描述小鼠MeV传入细胞在发育过程中的功能组织 针对这一群体的基因工具。目标2将记录来自MeV神经元的行为 在高分辨率运动跟踪期间的动物。使用该数据集，系统的量化 将建立口腔面部自主行为时MeV神经元活动的模型。《目标3》将扰乱 MEV神经元活动以了解MEV神经元在口面部的功能作用 行为。该项目的完成将涉及体内生理学的高水平培训， 行为分析和系统/计算技术。这项培训将利用一位富有的 神经电路和系统研究的环境，特别是基于 发起人和共同发起人的实验室里的感觉和运动系统神经科学。 总的来说，拟议的项目将定义信息编码属性 口腔面部运动过程中的本体感受器以及这一信息的功能作用 在行为过程中。这些结果可以为颌骨运动问题的治疗策略提供参考。 在临床上(如戴假牙的患者、颞下颌关节紊乱病等)。更多 总的来说，这项工作可以为本体感信息在运动中的作用提供新的见解。 控制，这对于对运动的基本理解具有广泛的影响 健康和病态的背景。

Project Summary Integration of sensory information with motor commands allows movement to be adaptable. For example, many survival-critical orofacial behaviors (chewing, drinking, breathing, etc.) involve updating movement trajectories based on interaction with objects (e.g. matching chewing patterns to food material properties). Proprioceptors, which are sensory afferents that provide information about body position, likely play critical roles in this process. However, given that most past recording of proprioceptors was not performed in awake animals, a clear understanding of proprioceptor movement coding in the awake context is lacking. This project will target and record from mouse jaw-innervating proprioceptors (which lie in the hindbrain mesencephalic trigeminal (MeV) nucleus) during orofacial behavior and test their functional role. Aim 1 will characterize the functional organization of mouse MeV afferents while developing genetic tools for targeting this population. Aim 2 will record from MeV neurons in behaving animals during high-resolution movement tracking. Using this dataset, a systematic quantitative model will be built for MeV neuron activity during voluntary orofacial behavior. Aim 3 will perturb MeV neuron activity to understand the functional role of MeV neurons in orofacial behavior. Completion of this project will involve high-level training in in vivo physiology, behavioral analysis, and systems/computational techniques. This training will draw upon a rich environment for neural circuit and systems research, especially based on the expertise in sensory and motor systems neuroscience in the labs of the Sponsor and Co-Sponsor. Collectively, the proposed project will define the information coding properties of proprioceptors during orofacial movement as well as probe the functional role of this information during behavior. These results could inform strategies for treatment of jaw motor problems seen in the clinic (i.e. denture-wearing patients, temporomandibular joint disorders, etc.). More broadly, this work can provide novel insights into the role of proprioceptive information in motor control, which has wide-ranging implications for the fundamental understanding of movement in healthy and pathological contexts.