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UCLA SPORE in Brain Cancer

加州大学洛杉矶分校孢子在脑癌中的应用

基本信息

批准号：
9982853
负责人：
Linda M Liau
金额：
$ 218.5万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-08-11 至 2022-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9982853
关键词：
Active Immunotherapy Acute Address Apoptosis Area Awareness Basic Science Bioinformatics Biological Markers Biometry Brain Brain Neoplasms California Cancer Patient Cells Clinic Clinical Clinical Research Clinical Trials Communities Companions Comprehensive Cancer Center Country Detection Development Diagnosis Disease Epigenetic Process Equilibrium Fostering Funding Glioblastoma Glioma Goals Grant Human Image Immune Evasion Immunotherapeutic agent Infrastructure International Knowledge Magnetic Resonance Imaging Malignant neoplasm of brain Metabolic Metabolism NCI Center for Cancer Research Paper Pathology Pathway interactions Patient Care Patients Phenotype Positron-Emission Tomography Public Health Publishing Radiation Reproduction spores Research Research Personnel Research Project Grants Research Support Resistance Resource Sharing Resources Scientist Specimen Survival Rate Testing Translational Research Translations United States National Institutes of Health Work anticancer research cancer type career career development checkpoint modulation clinical care clinical practice data management design immune checkpoint improved inhibitor/antagonist innovation mutant neoplastic cell neuro-oncology neuroimaging neurosurgery novel novel strategies novel therapeutic intervention novel therapeutics oncology program outcome forecast pre-clinical programs radiation resistance resistance mechanism stem cells targeted treatment therapy development therapy resistant translational approach translational research program tumor microenvironment

项目摘要

Overall: UCLA SPORE in Brain Cancer SUMMARY/ABSTRACT The objectives of the UCLA SPORE in Brain Cancer are to contribute significantly to progress in the diagnosis, prognosis, and treatment of brain cancer. These goals will be accomplished through multiple and diverse research projects involving mechanistic pre-clinical work and innovative clinical studies, with a particular focus on developing novel strategies to overcome the problem of treatment resistance. The broad, long-term objectives and aims of our brain cancer SPORE are as follows: 1) to investigate mechanisms of immune evasion following active immunotherapy, and develop rational combinations of immunotherapeutic strategies to overcome the immunosuppressive milieu of the brain tumor microenvironment; 2) to elucidate the alterations in metabolism associated with targeted therapy resistance, and exploit these metabolic vulnerabilities to induce intrinsic apoptosis of tumor cells; 3) to explore the concept of radiation-induced phenotype conversion of non-tumorigenic cells to glioblastoma-initiating cells as a mechanism for radiation resistance, and test new therapeutics to block such glioma stem cell conversion; and 4) to investigate the pathways of resistance to IDH inhibitors, and utilize novel epigenetic pathways to sensitize IDH-mutant gliomas to treatment. In order to achieve these translational research goals of our program, we propose four main projects involving: 1) active immunotherapy combined with immune checkpoint modulation for glioblastoma; 2) targeting metabolic vulnerabilities in glioblastoma cells; 3) inhibition of radiation-induced phenotype conversion to glioma-initiating stem cells; and 4) novel epigenetic treatment of IDH mutant gliomas. These translational research projects will be supported by shared resource cores in administration, biospecimen/pathology, neuroimaging, and biostatistics/bioinformatics/data management. Our program will also be responsive to SPORE themes by incorporating Developmental Research and Career Enhancement Programs in order to foster new approaches for assessing and treating brain cancer. Our diverse array of novel projects and state-of-the-art cores will likely make a significant impact on brain cancer patient care. Each project has been developed jointly by teams of basic and clinical researchers working together in a trans-disciplinary manner to address the most vexing problem in brain cancer – the development of treatment resistance. All four projects are highly translational and will reach human endpoints within the context of this SPORE grant period.

总的来说：加州大学洛杉矶分校的脑癌孢子