Pediatric Infectious Diseases, Enteric Health and Malnutrition in Pakistan (PIDEMP) Research Training Program

巴基斯坦儿科传染病、肠道健康和营养不良 (PIDEMP) 研究培训计划

• 批准号: 9983246
• 负责人: Syed Asad Ali
• 金额: $ 28.26万
• 依托单位: AGA KHAN UNIVERSITY (PAKISTAN)
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9983246
• 关键词: Acute-Phase Reaction; Address; Area; Bioethics; Biometry; Child; Childhood; Chronic; Clinical Markers; Clinical Nutrition; Clinical Research; Communicable Diseases; Country; Data Science; Development; Disease; Doctor of Philosophy; Educational workshop; Enteral; Epidemiology; Exposure to; Failure; Foundations; Functional disorder; Gastroenterology; Goals; Grant; Growth; Health; Immunization; Immunologics; Immunology; Impairment; Infectious Diseases Research; Inflammation; Laboratories; Malnutrition; Mucous Membrane; Neurocognitive; Nutritional Study; Oral; Organoids; Pakistan; Pathway interactions; Research; Research Personnel; Research Project Grants; Research Training; Scientist; Series; Short-Term Course; Small Intestines; Training; Training Programs; Underweight; Universities; Vaccines; Virginia; burden of illness; enteric pathogen; immunogenicity; low and middle-income countries; neglect; nutrition; programs; skills; socioeconomics

Project Summary/Abstract Approximately half of all children in Pakistan are stunted, 15% are wasted, and 40% are underweight. Stunting serves as a clinical marker for lifelong impairments in physical, immunological (including reduced vaccine immunogenicity), neurocognitive, and socioeconomic potential. Environmental Enteric Dysfunction (EED) is thought to be a key factor underlying malnutrition and subsequently stunting in children residing in low-and- middle income countries (LMICs) such as Pakistan. EED is an acquired, subclinical, small intestinal condition attributed to a continuous burden of immune stimulation by fecal-oral exposure to enteropathogens leading to a persistent acute phase response and chronic inflammation. EED is an excellent example of the interplay between infectious diseases and chronic malnutrition. Limited expertise and a paucity of formal training programs in pediatric infectious diseases and gastroenterology and nutrition in Pakistan are impeding progress in addressing this significant burden of disease. Through this proposal, we aim to build sustainable capacity in pediatric infectious disease and gastroenterology and nutrition research, specifically related to EED and its complications such as vaccine failure, undernutrition and subsequent growth failure in children residing in Pakistan. Training through this grant will leverage ongoing collaborative research projects and didactic (doctoral and graduate) programs currently offered at the Aga Khan University (AKU), Pakistan. We will achieve this via three training pathways of varying durations. Track I will include a series of short-term courses and workshops to be conducted on topics covering advanced wet bench laboratory skills, epidemiology, clinical nutrition and bioethics, all with an infectious diseases focus. Track II will leverage graduate programs (Master’s) in Epidemiology and Biostatistics and Clinical Research at AKU and in Data Science at the University of Virginia, USA for training candidates. Track III will produce PhD scholars working in the fields of mucosal immunology, organoids, developmental origins of health and diseases as well as clinical nutrition. Two prior successful cycles of this grant have firmly laid the foundation of infectious diseases research at AKU. We plan to leverage this framework in the next five years by producing a cadre of local, independent scientists studying the interplay of communicable and non-communicable diseases, which remain a neglected area of research throughout the world, and particularly in LMICs such as Pakistan. The overall impact of this training program will be to empower in-country local researchers to significantly reduce the burden of EED with an overarching goal of pediatric infectious disease and gastroenterology and nutrition research in Pakistan.

项目总结/摘要 巴基斯坦大约一半的儿童发育不良，15%消瘦，40%体重不足。发育迟缓 作为身体、免疫（包括减少疫苗） 免疫原性）、神经认知和社会经济潜力。环境性肠功能障碍（EED） 被认为是造成居住在低海拔地区的儿童营养不良和随后发育迟缓的一个关键因素， 中等收入国家（LMIC），如巴基斯坦。EED是一种获得性的亚临床小肠疾病 这归因于粪便-口腔暴露于肠道病原体导致的免疫刺激的持续负担， 持续急性期反应和慢性炎症。EED是一个很好的例子， 传染病和慢性营养不良。专业知识有限，缺乏正规培训方案， 巴基斯坦的儿科传染病、胃肠病学和营养学正在阻碍解决 这一重大疾病负担。通过这项提案，我们的目标是建立儿科的可持续能力， 传染病、胃肠病学和营养学研究，特别是与EED及其并发症有关的研究 例如疫苗接种失败、营养不良以及居住在巴基斯坦的儿童随后发育不良。培训 通过这笔赠款将利用正在进行的合作研究项目和教学（博士和研究生） 巴基斯坦阿加汗大学（AKU）目前提供的课程。我们将通过三项培训来实现这一目标。 不同持续时间的路径。第一轨道将包括一系列短期课程和讲习班， 主题涵盖先进的湿台实验室技能、流行病学、临床营养和生物伦理学， 传染病的焦点。轨道二将利用流行病学研究生课程（硕士）， AKU的生物统计学和临床研究以及美国弗吉尼亚大学的数据科学培训 候选人轨道三将产生博士学者在粘膜免疫学，类器官， 健康和疾病的发展起源以及临床营养。此前两次成功的循环 拨款为AKU的传染病研究奠定了坚实的基础。我们计划利用这个框架 在接下来的五年里，通过培养一批当地的独立科学家， 和非传染性疾病，这仍然是世界各地被忽视的研究领域， 特别是在巴基斯坦等中低收入国家。这一培训方案的总体影响将是增强国内 当地的研究人员，以显着减少负担的EED与一个总体目标，儿科感染 疾病和胃肠病学和营养研究在巴基斯坦。