Pediatric Infectious Diseases, Enteric Health and Malnutrition in Pakistan (PIDEMP) Research Training Program

巴基斯坦儿科传染病、肠道健康和营养不良 (PIDEMP) 研究培训计划

• 批准号: 10249216
• 负责人: Syed Asad Ali
• 金额: $ 27.94万
• 依托单位: AGA KHAN UNIVERSITY (PAKISTAN)
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10249216
• 关键词: Acute-Phase Reaction; Address; Area; Bioethics; Biometry; Child; Childhood; Chronic; Clinical Markers; Clinical Nutrition; Clinical Research; Communicable Diseases; Country; Data Science; Development; Disease; Doctor of Philosophy; Educational workshop; Enteral; Epidemiology; Exposure to; Failure; Foundations; Functional disorder; Gastroenterology; Goals; Grant; Growth; Health; Immunization; Immunologics; Immunology; Impairment; Infectious Diseases Research; Inflammation; Laboratories; Malnutrition; Mucous Membrane; Neurocognitive; Nutritional Study; Oral; Organoids; Pakistan; Pathway interactions; Research; Research Personnel; Research Project Grants; Research Training; Scientist; Series; Short-Term Course; Small Intestines; Training; Training Programs; Underweight; Universities; Vaccines; Virginia; burden of illness; enteric pathogen; immunogenicity; low and middle-income countries; neglect; nutrition; programs; skills; socioeconomics

Project Summary/Abstract Approximately half of all children in Pakistan are stunted, 15% are wasted, and 40% are underweight. Stunting serves as a clinical marker for lifelong impairments in physical, immunological (including reduced vaccine immunogenicity), neurocognitive, and socioeconomic potential. Environmental Enteric Dysfunction (EED) is thought to be a key factor underlying malnutrition and subsequently stunting in children residing in low-and- middle income countries (LMICs) such as Pakistan. EED is an acquired, subclinical, small intestinal condition attributed to a continuous burden of immune stimulation by fecal-oral exposure to enteropathogens leading to a persistent acute phase response and chronic inflammation. EED is an excellent example of the interplay between infectious diseases and chronic malnutrition. Limited expertise and a paucity of formal training programs in pediatric infectious diseases and gastroenterology and nutrition in Pakistan are impeding progress in addressing this significant burden of disease. Through this proposal, we aim to build sustainable capacity in pediatric infectious disease and gastroenterology and nutrition research, specifically related to EED and its complications such as vaccine failure, undernutrition and subsequent growth failure in children residing in Pakistan. Training through this grant will leverage ongoing collaborative research projects and didactic (doctoral and graduate) programs currently offered at the Aga Khan University (AKU), Pakistan. We will achieve this via three training pathways of varying durations. Track I will include a series of short-term courses and workshops to be conducted on topics covering advanced wet bench laboratory skills, epidemiology, clinical nutrition and bioethics, all with an infectious diseases focus. Track II will leverage graduate programs (Master’s) in Epidemiology and Biostatistics and Clinical Research at AKU and in Data Science at the University of Virginia, USA for training candidates. Track III will produce PhD scholars working in the fields of mucosal immunology, organoids, developmental origins of health and diseases as well as clinical nutrition. Two prior successful cycles of this grant have firmly laid the foundation of infectious diseases research at AKU. We plan to leverage this framework in the next five years by producing a cadre of local, independent scientists studying the interplay of communicable and non-communicable diseases, which remain a neglected area of research throughout the world, and particularly in LMICs such as Pakistan. The overall impact of this training program will be to empower in-country local researchers to significantly reduce the burden of EED with an overarching goal of pediatric infectious disease and gastroenterology and nutrition research in Pakistan.

项目总结/文摘