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Core F: Induced Pluripotent Stem Cell Core

核心F：诱导多能干细胞核心

基本信息

批准号：
10188386
负责人：
Mathew Mark Blurton-Jones
金额：
$ 27.84万
依托单位：
UNIVERSITY OF CALIFORNIA-IRVINE
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-06-15 至 2025-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10188386
关键词：
Aged, 80 and over Aging Alzheimer&apos s Disease Alzheimer&apos s disease risk Award Biological Biological Markers California Cell Line Cell physiology Cells Cellular biology Clustered Regularly Interspaced Short Palindromic Repeats Code Cognitive Collaborations Communities Consent Controlled Study Data Data Set Dementia Development Differentiation and Growth Down Syndrome Ethics Exhibits Fibroblasts Foundations Funding Generations Genes Genetic Genetic Diseases Genetic Risk Genetic study Genome engineering Genotype Goals Grant Human Impairment Late Onset Alzheimer Disease Link Longevity Mosaicism Mutation Neurochip PLCG2 gene Participant Pathologic Pathology Peripheral Blood Mononuclear Cell Population Postdoctoral Fellow Presenile Alzheimer Dementia Quantitative Trait Loci Research Research Personnel Resources Risk Risk Factors Sampling Single Nucleotide Polymorphism Skin Special Population Stem Cell Research Students System TREM2 gene Teacher Professional Development Training Training and Education United States United States National Institutes of Health Universities Untranslated RNA Variant Work base brain cell clinical biomarkers cohort cost data management education research gene correction genome wide association study induced pluripotent stem cell innovation mRNA Expression neuropathology next generation novel therapeutic intervention outreach polygenic risk score protein expression recruit repository resilience risk variant stem cell growth tau Proteins

项目摘要

Core F: Induced Pluripotent Stem Cell Core Project Summary/Abstract Genome wide association studies have identified almost 30 genes that are associated with altered risk of developing late-onset Alzheimer's disease (AD). Yet, precisely how those genes impact the function of human cells to either promote or protect against the development or progression of AD remains unclear. One promising approach that is increasingly being used to examine such questions involves the use of induced pluripotent stem cells (iPSCs), which can be generated from control and AD subjects and then differentiated into the key brain cells implicated in AD. In 2013, the UCI Alzheimer's disease research center (ADRC) became the first ADRC to establish an induced Pluripotent Stem Cell (iPSC) Core. Since then, the core has generated and provided iPSC lines from AD, MCI and control subjects to researchers around the world who are using these lines to examine the impact of AD genes on human cellular function. In the current application, the iPSC Core will continue to embrace new advances in AD genetics and CRISPR gene editing to generate and distribute additional highly unique iPSC lines from UCI's three ADRC cohorts (UDS, DS, and 90+). Through five specific aims, the iPSC Core will collaborate with AD researchers worldwide (Aims 1-5), employ innovative genetic studies and genome engineering to facilitate the study of genetic AD risk factors in late- onset AD and specialized AD populations (Aims 1, 3, 4), and educate the research and lay communities about the scientific applications and implications of AD iPSCs (Aim 5).

核心F：诱导多能干细胞核心