Age effects on memory and reward systems in decision making
年龄对决策中的记忆和奖励系统的影响
基本信息
- 批准号:10187476
- 负责人:
- 金额:$ 24.86万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-09-15 至 2024-05-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAffectAgingAlzheimer&aposs DiseaseAlzheimer&aposs disease pathologyBehavioralBindingBusinessesCaringCognitionCognitive agingCollaborationsCommunitiesComplexCorpus striatum structureCuesDecision MakingDecision Support SystemsDepositionDevelopmentDopamineDopamine ReceptorElderlyEnvironmentFaceFamilyFosteringFoundationsFunctional Magnetic Resonance ImagingFunctional disorderFutureGoalsHippocampus (Brain)HomeHumanImageIndividual DifferencesLaboratoriesLearningLinkMapsMeasuresMedialMediatingMedicalMemoryMentorsMethodsModelingNeuromodulatorOutcomePathologyPatternPerformancePersonal SatisfactionPositron-Emission TomographyProcessQuality of lifeResearchResearch ActivityResearch PersonnelResourcesRetirementRewardsRoleSchoolsShapesSolidSpecificitySystemTask PerformancesTechnologyTemporal LobeTestingTrainingTyrosineVentral StriatumWorkage effectage relatedbasecareercognitive processdesigndopamine systemexperiencefinancial decision makinghyperphosphorylated tauimprintinnovationneurochemistryneuroeconomicsneuroimagingnovelpre-clinicalpredictive modelingpredictive testprogramsprotein aggregationrelating to nervous systemresponseskillssupport networktau Proteinstau aggregationyoung adult
项目摘要
Project Summary
Aging is accompanied by profound changes in neurochemical systems as well as accumulation of aggregated
proteins. To date, the influence of these processes on cognition has been studied in isolation. The proposed
research takes novel steps to bridge these fields to develop an integrative model of how changes across
multiple neural systems interact to affect high-level decision making in aging.
Candidate and career goals: This project will support the candidate’s essential training and development in
the field of cognitive aging, with a particular focus on how decline in reward and memory systems interact to
contribute to decision making ability. The candidate has a strong track record of research defining the
functional mechanisms by which neuromodulators shape cognition. To support the candidate in launching a
sustainable, cross-disciplinary independent research program, two expert mentors will provide individualized
training. First, the candidate will train in the field of the neuroeconomics and financial decision making, which
she will apply to the field of cognitive aging. Second, the candidate will train in PET methods for assessing
Alzheimer’s disease pathology and accompanying medial temporal lobe (MTL) memory function in older
adults. This novel research program will capitalize on the candidate’s established expertise while developing
critical skills to connect two important lines of cognitive aging research.
Environment: The exceptional resources and scientific community at Lawrence Berkeley National Laboratory
and UC Berkeley Haas School of Business provide and ideal environment to foster the candidate’s
development into an innovative and successful independent investigator. The candidate will have access to
state-of-the-art human neuroimaging technology and will be supported by a rich institutional culture promoting
creative, cross-disciplinary collaborations.
Research activity: Aging is accompanied by 1) dysfunction of the dopamine system, which affects the
response to rewards in ventral striatum, and 2) aggregation of hyperphosphorylated tau, associated with MTL
degeneration and memory disruption. The proposed K99 studies will delineate the independent and interactive
roles of these processes in modulating central components of financial decision making: reward learning and
memory. These studies will combine PET imaging in healthy older adults, a novel laboratory task designed
specifically to probe striatal-MTL interactions, and a validated measure of real-world financial capacity. The
proposed R00 studies will pair the laboratory task with functional MRI to define the patterns of activation and
network activity between striatum and MTL that underlie age-related disruption in performance and best predict
individual differences in real-world financial capacity. Together, these studies will contribute to new models of
how cross-system interactions influence high-level cognition in aging while identifying potential targets for
remediating decline.
项目摘要
衰老伴随着神经化学系统的深刻变化以及聚集的
proteins.迄今为止,这些过程对认知的影响一直是孤立地研究的。拟议
研究采取了新的步骤,以弥合这些领域,以开发一个综合模型,如何改变跨越
多个神经系统相互作用以影响老龄化中的高级决策。
候选人和职业目标:该项目将支持候选人的基本培训和发展,
认知老化领域,特别关注奖励和记忆系统的下降如何相互作用,
有助于决策能力。候选人有一个强大的研究记录,定义了
神经调质塑造认知的功能机制。支持候选人发起一个
可持续的,跨学科的独立研究计划,两位专家导师将提供个性化的
训练首先,候选人将接受神经经济学和金融决策领域的培训,
她将应用于认知老化领域。其次,候选人将接受PET方法的培训,
老年人阿尔茨海默病病理学和伴随的内侧颞叶(MTL)记忆功能
成年人了这个新的研究计划将利用候选人的既定专业知识,同时发展
关键技能连接认知老化研究的两条重要路线。
环境:劳伦斯伯克利国家实验室的特殊资源和科学界
和加州大学伯克利分校哈斯商学院提供理想的环境,以培养候选人的
发展成为一个创新和成功的独立调查员。候选人将有权访问
最先进的人类神经成像技术,并将得到丰富的机构文化的支持,
创造性的跨学科合作。
研究活动:衰老伴随着1)多巴胺系统的功能障碍,这会影响大脑的功能。
腹侧纹状体对奖励的反应,以及2)与MTL相关的过度磷酸化tau蛋白的聚集
退化和记忆中断建议的K99研究将描述独立和互动的
这些过程在调节财务决策的核心组成部分中的作用:奖励学习和
记忆这些研究将在健康老年人中结合联合收割机PET成像,
特别是探测纹状体-MTL相互作用,以及真实世界财务能力的有效测量。的
拟议的R 00研究将把实验室任务与功能性MRI配对,以定义激活模式,
纹状体和MTL之间的网络活动是年龄相关的表现中断的基础,
现实世界中的个人财务能力差异。总之,这些研究将有助于新的模式,
跨系统的相互作用如何影响老年人的高层次认知,同时确定潜在的目标,
补救性下降。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Anne Shively Berry的其他文献
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{{ truncateString('Anne Shively Berry', 18)}}的其他基金
Dopaminergic mechanisms of resilience to Alzheimer's disease neuropathology
阿尔茨海默病神经病理学恢复的多巴胺能机制
- 批准号:
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- 资助金额:
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Upregulated Norepinephrine Synthesis Capacity in Aging
衰老过程中去甲肾上腺素合成能力上调
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Upregulated Norepinephrine Synthesis Capacity in Aging
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10629346 - 财政年份:2022
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Locus Coeruleus Biomarker Development for Early Detection of Alzheimers Disease in Humans
用于早期检测人类阿尔茨海默病的蓝斑生物标记物开发
- 批准号:
10194679 - 财政年份:2021
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Locus Coeruleus Biomarker Development for Early Detection of Alzheimers Disease in Humans
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Dopaminergic modulation of networks mediating cognitive flexibility in older adul
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8874736 - 财政年份:2014
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