Alcohol Research Training in epigenetics and pathophysiology (ARTEP)

摘要： 酒精使用障碍(AUD)的特征是强迫性饮酒或失控 因为酗酒。成瘾的发展涉及到几个关键大脑的神经生物学变化。 在酒精依赖的行为表现中起作用的区域。表观遗传调控 (组蛋白和DNA化学修饰)基因表达是基因研究领域的一个重要领域。 强调基因与环境因素相互作用的重要性的神经科学。这款T32 题为“表观遗传学和病理生理学酒精研究培训”(ARTEP)的培训补助金 为直接向博士前(神经科学或心理学博士)提供培训而开发的 博士后研究员(博士、医学博士/博士毕业生)研究表观遗传和分子过程在 酒精的神经适应性和行为反应以及酒精中毒的病理生理学。少校 为NIAAA资助的酒精研究中心提供的T32培训补助金的目标 伊利诺伊大学芝加哥分校(UIC)的表观遗传学研究(CARE)将为年轻人提供培训 研究酒精成瘾的表观遗传学基础，并在这方面发展领先的成瘾研究人员 神经科学的新兴领域。除了在成瘾研究方面的出色培训外，学员还将获得 有针对性的补充培训，包括授课课程、研讨会、在全国和 国际科学会议、负责任的研究行为、研究数据处理和管理 以及手稿和赠款写作。走出ARTEP的学员将成为未来的独立 酒精研究人员推动表观遗传学和神经生物学的前沿研究，以更好地了解 AUD的病理生理学。酒精研究培训计划的首要目标是 为年轻研究人员提供关于分子和行为表观遗传机制的培训 AUD的表型。目标是：1)提供统一的培训，并应用多学科 通过让在动物领域具有专业知识的资深研究人员作为教师赞助人来采取这种方法 模型、人体研究、组织培养、人类死后脑研究、神经成像、电生理学、 精神病学、解剖学、表观遗传学、分子生物学和生物信息学，涵盖广泛的主题 上瘾。2)为研究生和研究生提供资源和科学丰富的环境 在酒精中毒的表观遗传学研究方面接受适当培训的博士研究员，使这些研究员成为独立的研究员 酒精研究人员。3)为受训者提供行政和科学领导，并将其发展为 成为领先的酒精研究人员。4)教学员如何准备研究补助金申请(F或 K拨款机制)，进行独立研究，并在大学担任教职。这 以表观遗传学为重点的培训计划在酒精中毒研究中非常独特，将加速培训 酒精研究领域下一代才华横溢的年轻科学家和临床医生。

Abstract: Alcohol use disorder (AUD) is characterized by a pattern of compulsive alcohol drinking or a loss of control over alcohol drinking. The development of addiction involves neurobiological changes in several key brain regions that play a role in the behavioral manifestations of ethanol dependence. Epigenetic regulation (Histone and DNA chemical modifications) of gene expression is an important area in the field of neuroscience that emphasizes the importance of gene interactions with environmental factors. This T32 training grant entitled “Alcohol Research Training in Epigenetics and Pathophysiology” (ARTEP) is developed in order to directly provide training to pre-doctoral (PhD in neuroscience or psychology) and post-doctoral fellows (PhD, MD/PhD graduates) on epigenetic and molecular processes that play a role in the neuroadaptive and behavioral responses to ethanol as well as the pathophysiology of alcoholism. The major objective of this T32 training grant for the NIAAA funded Alcohol Research Center entitled “Center for Alcohol Research in Epigenetics (CARE)” at the University of Illinois at Chicago (UIC) is to provide training to young researchers in the epigenetic basis of alcohol addiction and to develop leading addiction researchers in this emerging field of neuroscience. Besides outstanding training in addiction research, trainees will also receive supplemental targeted training that will include didactic courses, seminars, presentations at national and international scientific meetings, responsible research conduct, research data handling and management as well as manuscript and grant writing. Trainees coming out of ARTEP will become future independent alcohol researchers to promote cutting edge research in epigenetics and neurobiology to better understand the pathophysiology of AUD. The overarching goal of the alcohol research training program is to provide training to young researchers in epigenetic mechanisms of molecular and behavioral phenotypes of AUD. The objectives are: 1) To provide unified training and apply a multidisciplinary approach by involving established investigators as faculty sponsors with expertise in areas of animal models, human research, tissue culture, human post-mortem brain studies, neuroimaging, electrophysiology, psychiatry, anatomy, epigenetics, molecular biology, and bioinformatics to cover a wide range of topics of addiction. 2) To provide resources and a scientifically enriched environment for graduate students and post- doctoral fellows for suitable training in epigenetic studies in alcoholism so these fellows become independent alcohol researchers. 3) To provide administrative and scientific leadership to trainees and develop them to become leading alcohol researchers. 4) To teach trainees how to prepare research grant applications (F or K grant mechanisms), perform independent research and occupy faculty positions at universities. This training program focusing on epigenetics is very unique in alcoholism research and will accelerate the training of the next generation of bright young scientists and clinicians in the field of alcohol research.