Alcohol Research Training in epigenetics and pathophysiology (ARTEP)

表观遗传学和病理生理学酒精研究培训 (ARTEP)

• 批准号: 10188341
• 负责人: SUBHASH C. PANDEY
• 金额: $ 30.32万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10188341
• 关键词: Epigenetic Process; Functional disorder; Research Training; alcohol research

Abstract: Alcohol use disorder (AUD) is characterized by a pattern of compulsive alcohol drinking or a loss of control over alcohol drinking. The development of addiction involves neurobiological changes in several key brain regions that play a role in the behavioral manifestations of ethanol dependence. Epigenetic regulation (Histone and DNA chemical modifications) of gene expression is an important area in the field of neuroscience that emphasizes the importance of gene interactions with environmental factors. This T32 training grant entitled “Alcohol Research Training in Epigenetics and Pathophysiology” (ARTEP) is developed in order to directly provide training to pre-doctoral (PhD in neuroscience or psychology) and post-doctoral fellows (PhD, MD/PhD graduates) on epigenetic and molecular processes that play a role in the neuroadaptive and behavioral responses to ethanol as well as the pathophysiology of alcoholism. The major objective of this T32 training grant for the NIAAA funded Alcohol Research Center entitled “Center for Alcohol Research in Epigenetics (CARE)” at the University of Illinois at Chicago (UIC) is to provide training to young researchers in the epigenetic basis of alcohol addiction and to develop leading addiction researchers in this emerging field of neuroscience. Besides outstanding training in addiction research, trainees will also receive supplemental targeted training that will include didactic courses, seminars, presentations at national and international scientific meetings, responsible research conduct, research data handling and management as well as manuscript and grant writing. Trainees coming out of ARTEP will become future independent alcohol researchers to promote cutting edge research in epigenetics and neurobiology to better understand the pathophysiology of AUD. The overarching goal of the alcohol research training program is to provide training to young researchers in epigenetic mechanisms of molecular and behavioral phenotypes of AUD. The objectives are: 1) To provide unified training and apply a multidisciplinary approach by involving established investigators as faculty sponsors with expertise in areas of animal models, human research, tissue culture, human post-mortem brain studies, neuroimaging, electrophysiology, psychiatry, anatomy, epigenetics, molecular biology, and bioinformatics to cover a wide range of topics of addiction. 2) To provide resources and a scientifically enriched environment for graduate students and post- doctoral fellows for suitable training in epigenetic studies in alcoholism so these fellows become independent alcohol researchers. 3) To provide administrative and scientific leadership to trainees and develop them to become leading alcohol researchers. 4) To teach trainees how to prepare research grant applications (F or K grant mechanisms), perform independent research and occupy faculty positions at universities. This training program focusing on epigenetics is very unique in alcoholism research and will accelerate the training of the next generation of bright young scientists and clinicians in the field of alcohol research.

摘要： 酒精使用障碍（AUD）的特征是强迫性饮酒或失控的模式 因为喝酒成瘾的发展涉及几个关键大脑的神经生物学变化 在酒精依赖的行为表现中起作用的区域。表观遗传调控 基因表达的组蛋白和DNA化学修饰（Histone and DNA chemical modifications）是基因修饰领域的重要领域。 强调基因与环境因素相互作用重要性的神经科学。T32 题为“表观遗传学和病理生理学酒精研究培训”（ARTEP）的培训赠款是 开发，以直接提供培训，以博士前（博士在神经科学或心理学）， 博士后研究员（博士，医学博士/博士毕业生）在表观遗传和分子过程中发挥作用， 对酒精的神经适应性和行为反应以及酒精中毒的病理生理学。主要 该T32培训补助金的目的是为NIAAA资助的酒精研究中心，名为“酒精中心 芝加哥伊利诺斯大学（UIC）的“表观遗传学研究（CARE）”是为年轻的 研究人员在酒精成瘾的表观遗传基础，并发展领先的成瘾研究人员在这方面 神经科学的新兴领域除了在成瘾研究方面的出色培训外， 有针对性的补充培训，包括教学课程、研讨会、在国家和 国际科学会议、负责任的研究行为、研究数据处理和管理 以及手稿和资助写作。从ARTEP毕业的学员将成为未来的独立人士 酒精研究人员促进表观遗传学和神经生物学的前沿研究，以更好地了解 AUD的病理生理机制。酒精研究培训计划的总体目标是 为年轻的研究人员提供分子和行为的表观遗传机制方面的培训 AUD表型目标是：1）提供统一的培训，并采用多学科 方法通过涉及既定的研究人员作为教师赞助商与动物领域的专业知识 模型，人类研究，组织培养，人类死后大脑研究，神经成像，电生理学， 精神病学，解剖学，表观遗传学，分子生物学和生物信息学，以涵盖广泛的主题， 成瘾2)为研究生和博士后提供资源和科学丰富的环境， 博士研究员在酒精中毒的表观遗传学研究中进行适当的培训， 酒精研究者3)为学员提供行政和科学领导，并培养他们 成为领先的酒精研究者。4)教导学员如何准备研究资助申请（F或 K赠款机制），进行独立研究，并在大学担任教职。这 专注于表观遗传学的培训计划在酒精中毒研究中非常独特，将加速培训 在酒精研究领域的下一代聪明的年轻科学家和临床医生。