National Drug Early Warning System Coordinating Center

项目总结/摘要 我们的团队热情地提交了这个建议，作为下一个NDEWS协调中心（CC）的回应 至RFA DA-20-016。CC由Cottler实验室（流行病学）牵头，研究人员来自 佛罗里达大学成瘾研究与教育中心（尼克松，戈德伯格，斯特里），帕勒什大学 纽约大学实验室和佛罗里达的机器感知和认知机器人实验室-巴伦霍尔茨） 大西洋大学。我们的CC将保持强有力的哨兵监测工作，同时扩大我们的早期预警 网络站点，增加领先的指标，超越滞后的城市一级的数据。我们将延长 NIDA资助的研究人员的工作，同时协调和分析数据，及时和系统地 notifications.新的NDEWS CC将致力于无缝过渡正在进行的工作，先进的方法， 方法，建立和参与科学咨询小组（SAG），并与所有联合体合作 1）提供一个由12个NDEWS站点组成的预警网络， 6个社区流行病学工作组站点，用于对城市、农村和郊区进行持续监测; 2） 利用社区一级既定和新的关键指标进行持续监测， 可获得性、使用和已知物质的后果，在所有地点进行标准化， 3）采用和利用新的监测方法，以确保早期发现 毒品和新兴毒品趋势的信号，包括来自DanceSafe“毒品检查员”、Rapid Street 报告（RSR）与头发测试的接触，实施虚拟健康街物质 用户网络，并开发一种创新的机器学习方法，以检测是否出现恶意软件 通过药品零售商（包括“暗网”）和社交媒体平台实时发布; 4）协调 标准化的指标定义，所有传入的监测数据与输入的NIDA，SAG，和早期 预警网络专家;促进数据的跨站点可比性;管理质量控制;组织， 协调和汇总数据，并提供组织和后勤支持; 5）传播调查结果 通过仿照佛罗里达药物相关结果监测和跟踪系统的仪表板快速 （FROST）;定期更新和警报的推送通知;网络研讨会;虚拟我们的社区我们的健康小镇 大厅会议;传统上通过官方报告、同行评议的出版物、媒体和年度会议 在CPDD和其他地方报告; 6）就以下主题进行实地流行病学调查： 紧急危机或需要; 7）为企业提供运营、行政和后勤支持， 8）培养下一代科学家掌握NDEWS方法。 NDEWS具有未实现的潜力，有了这笔资金，我们将改变文化，使NDEWS NIDA和该领域的去源在美国的药物趋势。它将提供循证预防， 采取干预战略，最终减少世界各地使用药物的有害影响。

PROJECT SUMMARY/ABSTRACT Our team enthusiastically submits this proposal to be the next NDEWS Coordinating Center (CC) in response to RFA DA-20-016. The CC is spearheaded by the Cottler Lab (Epidemiology), with investigators from University of Florida's Center for Addiction Research & Education (Nixon, Goldberger, Striley), the Palamar Lab at New York University and the Machine Perception and Cognitive Robotics Lab-Barenholtz) at Florida Atlantic University. Our CC will maintain strong sentinel surveillance efforts while expanding our Early Warning Network sites, adding leading edge indicators that extend beyond lagged city-level data. We will extend the work of NIDA-funded researchers, while harmonizing and analyzing data, with timely and systematic notifications. The new NDEWS CC will work to seamlessly transition on-going efforts, advance methods and approaches, establish and engage a Scientific Advisory Group (SAG), and collaborate with all consortium components to accomplish these Specific Aims: 1) Provide an Early Warning Network of 12 NDEWS sites and 6 Community Epidemiology Workgroup sites for ongoing surveillance of urban, rural, and suburban areas; 2) Utilize established and new key community-level indicators for ongoing surveillance to assess trends in availability, use, and consequences of NPS and known substances, standardized across all sites to facilitate cross-site analyses; 3) Incorporate and leverage novel surveillance methods to ensure early detection of signals of NPS and emerging drug trends, including data from DanceSafe “drug checkers,” Rapid Street Reporting (RSR) with hair testing for NPS exposure, the implementation of a virtual HealthStreet substance user network, and development of an innovative machine learning approach to detect emergence of NPS in real-time through drug retailers (including the “darknet”) and social media platforms; 4) Harmonize standardized indicator definitions for all incoming surveillance data with the input of NIDA, the SAG, and Early Warning Network experts; facilitate cross-site comparability of data; manage quality control; organize, coordinate, and summarize data, and provide organizational and logistical support; 5) Disseminate findings quickly via dashboards modeled after Florida Drug-related Outcomes Surveillance and Tracking System (FROST); push notifications for regular updates and alerts; webinars; virtual Our Community Our Health Town Hall meetings; and traditionally through official reports, peer-reviewed publications, media, and annual reporting at CPDD, and elsewhere; 6) Conduct on-the-ground epidemiologic investigations on topics of immediate crisis or need; 7) Provide operational, administrative, and logistical support to the enterprise and NIDA; and 8) Train the next generation of scientists in NDEWS methodology. NDEWS has unrealized potential, and with this funding, we will transform the culture so that NDEWS is NIDA's and the field's go-to source for drug trends in the US. It will provide evidence-based prevention and intervention strategies to eventually reduce the harmful effects of substance use around the world.