Integrating Wastewater-Based Epidemiology into the National Drug Early Warning System Coordinating Center to Track Community Health Trends

将基于废水的流行病学纳入国家药物预警系统协调中心，以跟踪社区健康趋势

• 批准号: 10375878
• 负责人: Linda B. Cottler
• 金额: $ 15.25万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-05-01 至 2022-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10375878
• 关键词: Address; Amphetamines; Behavior; Biological; Businesses; COVID-19; Chemicals; Chemistry; Collection; Communication; Communities; Community Health; Complement; Consumption; Data; Data Set; Drug Targeting; Drug abuse; Drug usage; Economics; Environmental Health; Epidemiology; Event; Fentanyl; Festival; Fingerprint; Florida; Health; Health Professional; Health trends; Heroin; Hot Spot; Hour; Human; Individual; Industry; Legal; Life Style; Location; Mass Spectrum Analysis; Measurement; Measures; Methods; Monitor; Parents; Patient Self-Report; Pattern; Pharmaceutical Preparations; Plants; Population; Population Sizes; Prevalence; Process; Public Health; Quarantine; Sampling; Scientist; Sentinel; Site; Sports; Surveys; System; Techniques; Testing; Time; Toxicology; Universities; Urban Community; Validation; Visualization software; Water; Work; aged; analog; base; cost; cost effective; data dissemination; data integration; epidemiologic data; epidemiology study; fighting; global health; illicit drug use; innovation; interest; multidisciplinary; new therapeutic target; novel; novel therapeutics; programs; public health intervention; rapid technique; response; sample collection; substance use; success; surveillance data; surveillance study; tool; trend; wastewater epidemiology; wastewater samples; wastewater screening

SUMMARY Wastewater-based epidemiology (WBE) is an innovative and cost-effective approach that complements traditional, yet important, self-reporting methods and biospecimen testing to construct drug use trends on a community scale. WBE has been successfully applied to estimate consumption of targeted illegal drugs and has more recently been applied to detect the emergence of new psychoactive substances (NPS) in varied settings such as large urban communities and during/after smaller focused events (e.g., festivals, sports events). Yet, this approach has not formally been integrated into the National Drug Early Warning System (NDEWS) Coordinating Center, a platform which provides experts and communities with the most timely information on emerging substance use trends through traditional and novel surveillance data as well as on- the-ground epidemiologic investigations. Therefore this proposal aims to provide accurate up-to-date wastewater chemical/drug surveillance data from designated partner sites of the NDEWS Coordinating Center and wastewater industry, calculate drug consumption over time, and align our approach with existing NDEWS surveillance data to help identify hot spots or new emerging trends across communities on a national scale. This will be accomplished through 2 aims: 1) Coordinate collection and analysis of wastewater samples from NDEWS Sentinel Site locations for known drugs/metabolites and NPS using high-end mass spectrometry approaches and 2) Validate and disseminate actionable WBE data by comparing data from on-going drug use surveillance studies as part of NDEWS with WBE generated drug trends, integrate WBE data with public health and utility information to develop a visualization tool and disseminate information via the NDEWS Coordinating Center and through 2 way regular communication with our water industry and public health partners and their local communities. Our proof-of-concept proposal will provide the benefits of easy integration of WBE into the existing NDEWS framework, and data sets that are immediately available to the NDEWS partners which will, importantly, inform current and emerging drug use trends that can be used to refine public health measures.

摘要 基于废水的流行病学(WBE)是一种创新且经济高效的方法，它补充了 传统而又重要的自我报告方法和生物素测试，以构建药物使用趋势 社区规模。WBE已成功地应用于估计靶向非法药物的消费量和 最近被应用于检测各种不同类型的新精神活性物质(NP)的出现 环境，如大型城市社区和在较小的重点活动期间/之后(例如，节日、体育 事件)。然而，这一做法尚未正式纳入国家毒品预警系统 (NDEWS)协调中心，为专家和社区提供最及时的 通过传统和新的监测数据以及关于-- 实地流行病学调查。因此，本提案旨在提供准确的最新信息 来自NDEWS协调指定伙伴地点的废水化学/药物监测数据 中心和废水行业，计算随时间推移的药物消耗，并使我们的方法与 现有的NDEWS监视数据，可帮助确定热点或新的新兴趋势 全国范围内的社区。这将通过两个目标来实现：1)协调收集和 NDEWS哨兵现场废水样本中已知药物/代谢物和NPS的分析 使用高端质谱学方法和2)通过以下方式验证和传播可操作的WBE数据 将作为NDEWS一部分的正在进行的药物使用监测研究的数据与WBE产生的药物进行比较 趋势，将WBE数据与公共卫生和公用事业信息集成，以开发可视化工具和 通过NDEWS协调中心和通过双向定期沟通传播信息 我们的水务行业和公共卫生合作伙伴及其当地社区。我们的概念验证提案将 提供将WBE轻松集成到现有NDEWS框架的好处，以及符合以下条件的数据集 立即提供给NDEWS合作伙伴，这将重要地告知当前和新出现的药物使用情况 可用于完善公共卫生措施的趋势。