Biomarkers and mechanisms of metal and mixed metal exposures
金属和混合金属暴露的生物标志物和机制
基本信息
- 批准号:10353202
- 负责人:
- 金额:$ 35.08万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-08-15 至 2027-06-30
- 项目状态:未结题
- 来源:
- 关键词:AcuteAddressAdultAdverse effectsAntioxidantsArsenicAtherosclerosisAutoimmunityBiologicalBiological MarkersBiological MonitoringBlood VesselsCell modelCellsChronicChronic DiseaseClinical TrialsCollectionCommunitiesCommunity HealthDNA DamageDNA Repair GeneDNA Repair InhibitionDataDecision MakingDetectionDevelopmentDiabetes MellitusDiseaseEnvironmentEnvironmental ExposureEnvironmental HealthEnvironmental ProtectionEvaluationExperimental ModelsExposure toFutureGenerationsGoalsHealthHealth PrioritiesHealth SurveysHumanHypertensionImmuneImmune TargetingImmunologicsIndividualInflammationInflammatoryInflammatory ResponseInterventionKidney DiseasesKnowledgeLinkLungMetal exposureMetalsMicronutrientsMiningModificationNative AmericansNew MexicoNutrientNutrition SurveysOutcomeOxidation-ReductionOxidative StressOxidative Stress InductionPatternPopulationPopulation StudyProcessProductionProteinsPublishingReactive Oxygen SpeciesResearchRiskRisk AssessmentRisk ReductionSamplingScienceSeleniumSignal Recognition ParticleSignal TransductionSiteSuperfundTestingTimeToxic effectUniversitiesUraniumVanadiumWorkZincZinc Fingersbasebiological adaptation to stresscytokinecytotoxicitydietaryexperimental studyexposure pathwayexposure routeimmunoregulationimmunotoxicityinsightmacromoleculemembermetal poisoningmodel designpopulation basedprogramstherapy developmenttoxic metaltribal landsuptakewasting
项目摘要
Project #1 – BioProject on Community Exposures (BP Comm) - SUMMARY
With partnering Native American communities, the UNM Metals Exposure and Toxicity Assessment on
Tribal Lands in the Southwest (UNM METALS) team has obtained evidence for community level exposures
and health risks associated with more than 1100 abandoned uranium mine (AUM) waste sites on their tribal
lands. Biomonitoring results confirm that community members are exposed to uranium and other metals
beyond national norms, leading to concerns about potential impact on health. Based on published and
preliminary findings, we will test the hypothesis that exposure to the unique mixtures of environmental metals
associated with AUMs promotes oxidative stress and inflammatory response, processes known to promote
immune dysregulation and development of numerous chronic diseases. Furthermore, we hypothesize that
dietary mitigation strategies can be elucidated based on mechanisms of toxicity of specific metals and metal
mixtures. In Aim 1 we will work to delineate associations between metals detected by biomonitoring, and
biomarkers of oxidative stress, inflammation and immune modulation. The findings from Aim 1 are expected to
provide critical information on systemic consequences of environmental metal exposures. Although uranium
has been the focus of community concern, findings from the UNM METALS Environmental Projects and
human biomonitoring highlight that other toxic metals are prevalent in the environment and present at elevated
levels in the population. Experimental studies in Aim 2 will focus on oxidative stress generated by community-
relevant metals and metal mixtures as an underlying mechanism leading to alterations in inflammatory
response and immune modulation. We will select experimental endpoints and exposure patterns observed in
the community to optimize human relevance of Aim 2 studies. Detailed mechanistic analyses will be performed
to establish the basis for metal interactions including potential beneficial metal-metal interactions of the
antioxidant metal micronutrients (zinc/Zn and selenium/Se). Studies on Zn and Se interactions with toxic
metals and metal mixtures may inform tractable strategies for mitigating the adverse effects of environmental
metal exposures in human populations. This project is responsive to community concerns and the outcomes
are expected to 1) provide insights into biological consequences of understudied toxic metals identified in
environmental samples and elevated in biospecimens from the community, 2) expand mechanistic knowledge
of the impact of specific metals and metal mixtures as well as the basis for metal:metal interactions in human
immune cells, and 3) experimentally test the potential of mechanism-based interventions to confer protection
from environmental metal exposures. BP Comm addresses SRP mandates 1, 2 and 4: Detection and
Evaluation of Effects, Risk Assessment and Risk Reduction, respectively.
项目#1 -社区暴露生物项目(BP Comm) -摘要
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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LAURIE G HUDSON其他文献
LAURIE G HUDSON的其他文献
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{{ truncateString('LAURIE G HUDSON', 18)}}的其他基金
Illuminating the functions and translational potential of CDC42BP/MRCK kinases in ovarian cancer
阐明 CDC42BP/MRCK 激酶在卵巢癌中的功能和翻译潜力
- 批准号:
10216717 - 财政年份:2021
- 资助金额:
$ 35.08万 - 项目类别:
Mutational Signatures of a Combined Environmental Exposure: Arsenic and Ultraviolet Radiation
综合环境暴露的突变特征:砷和紫外线辐射
- 批准号:
10844717 - 财政年份:2020
- 资助金额:
$ 35.08万 - 项目类别:
Mutational Signatures of a Combined Environmental Exposure: Arsenic and Ultraviolet Radiation
综合环境暴露的突变特征:砷和紫外线辐射
- 批准号:
10330581 - 财政年份:2020
- 资助金额:
$ 35.08万 - 项目类别:
Biomarkers and mechanisms of metal and mixed metal exposures
金属和混合金属暴露的生物标志物和机制
- 批准号:
10707512 - 财政年份:2017
- 资助金额:
$ 35.08万 - 项目类别:
Zinc Chemoprevention of Arsenic Co-Carcinogenesis
锌对砷协同致癌作用的化学预防
- 批准号:
8762020 - 财政年份:2014
- 资助金额:
$ 35.08万 - 项目类别:
Zinc Chemoprevention of Arsenic Co-Carcinogenesis
锌对砷协同致癌作用的化学预防
- 批准号:
9325454 - 财政年份:2014
- 资助金额:
$ 35.08万 - 项目类别:
Arsenic co-carcinogenesis with UVR: nitrosation and oxidation of target proteins
砷与 UVR 的协同致癌作用:目标蛋白的亚硝化和氧化
- 批准号:
8856568 - 财政年份:2012
- 资助金额:
$ 35.08万 - 项目类别:
Capitalizing on NSAID enantiomer selectivity for cancer prevention and therapy(PQ
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8625502 - 财政年份:2012
- 资助金额:
$ 35.08万 - 项目类别:
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