PET Insert for Preclinical PET-MRI

用于临床前 PET-MRI 的 PET 插入物

• 批准号: 10188952
• 负责人: Christopher A Flask
• 金额: $ 41.29万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-15 至 2023-07-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10188952
• 关键词: 3-Dimensional; Advisory Committees; Alzheimer' s Disease; Area; Cardiovascular Diseases; Clinical Sciences; Comprehensive Cancer Center; Computer software; Cystic Fibrosis; Detection; Diabetes Mellitus; Digestive System Disorders; Faculty; Genes; Genetic Diseases; Goals; Healthcare; Image; Image Analysis; Immunology; Inflammation; Inflammatory Bowel Diseases; Institution; Licensing; Magnetic Resonance Imaging; Metabolism; Morphologic artifacts; Motion; Multiple Sclerosis; National Institute of Diabetes and Digestive and Kidney Diseases; Neurodegenerative Disorders; Patient Care; Performance; Physiologic Monitoring; Policies; Positron-Emission Tomography; Research; Research Personnel; Resolution; Signal Transduction; Stroke; System; Translational Research; Universities; cancer genetics; cost; experience; image visualization; imaging agent; imaging study; improved; metabolic imaging; molecular imaging; pre-clinical; programs; radio frequency; ranpirnase; respiratory; soft tissue; technology development

Project Summary We propose to purchase a new Cubresa MRI-Compatible PET insert to be combined with our existing 9.4T Bruker Biospec preclinical MRI scanner at Case Western Reserve University (CWRU). This new PET insert will create the first preclinical PET-MRI capability in Cleveland that will efficiently synergize our extensive preclinical PET and MRI imaging research programs to support 25 major users with research in the areas of PET and MRI technology developments, molecular imaging agents, new gene editing strategies, metabolism, inflammation, and immunology. With this new PET-MRI capability, these investigators will be able to combine the unmatched sensitivity of 3D PET imaging with the high spatial resolution and wide range of selectable soft tissue contrasts provided by MRI. The proposed system will also result in significantly reduced imaging costs and inherent 3D PET-MRI image co-registration in comparison to sequential PET-CT and MRI. The proposed system will also include: 1) PET- optimized radiofrequency coils enabling high-sensitivity MRI signal detection; 2) respiratory gating to limit motion artifacts; 3) multiple VivoQuant software licenses to provide efficient image visualization and analysis; and 4) physiologic monitoring and control capabilities necessary for effective metabolic imaging studies. These capabilities will broadly benefit an interdisciplinary group of investigators with the ultimate goal of improving health care for patients with cancer, genetic diseases including cystic fibrosis, inflammatory bowel disease, neurodegenerative diseases such as Alzheimer’s Disease and multiple sclerosis, cardiovascular disease, diabetes, and stroke. This new preclinical PET-MRI capability will be available to all regional investigators and will be operated by the Imaging Research Core at CWRU which is an integral component of multiple research centers at CWRU including the Case Comprehensive Cancer Center (NCI P30 CA043703), the Digestive Diseases Research Core Center (NIDDK P30 DK097948), the Clinical and Translational Science Collaborative (NCATS UL1 TR002548), and the Cystic Fibrosis Research Center. This ongoing support for the Imaging Research Core is in addition to the direct institutional support of $100,000 to partially offset the cost for this new PET imaging insert. An advisory committee with highly experienced PET and MRI faculty at CWRU and external institutions will oversee the organization and usage of the system and recommend policies to maintain system performance and maximize utilization.

项目摘要 我们建议购买一种新的Cubresa MRI兼容PET衬垫， 凯斯西储大学现有9.4 T Bruker Biospec临床前MRI扫描仪 （CWRU）。这种新的PET插入物将在克利夫兰创建第一个临床前PET-MRI功能， 将有效地协同我们广泛的临床前PET和MRI成像研究计划， 支持25个主要用户在PET和MRI技术发展领域的研究， 分子成像剂，新的基因编辑策略，代谢，炎症， 免疫学有了这种新的PET-MRI功能，这些研究人员将能够将联合收割机 具有高空间分辨率和宽范围的3D PET成像的无与伦比的灵敏度 MRI提供的可选软组织对比度。拟议的系统还将导致 显着降低成像成本和固有的3D PET-MRI图像配准， 与连续PET-CT和MRI进行比较。拟议的系统还将包括：1）PET- 优化射频线圈，实现高灵敏度MRI信号检测; 2）呼吸门控 限制运动伪影; 3）多个VivoQuant软件许可证，以提供有效的图像 可视化和分析;以及4）生理监测和控制能力， 有效的代谢成像研究。这些能力将广泛有利于跨学科 一组研究人员的最终目标是改善癌症患者的医疗保健， 遗传性疾病，包括囊性纤维化、炎症性肠病、神经退行性疾病、 疾病如阿尔茨海默病和多发性硬化症，心血管疾病，糖尿病， 和中风这种新的临床前PET-MRI功能将提供给所有区域研究者 并将由CWRU的成像研究核心操作，CWRU是CWRU的一个组成部分， CWRU的多个研究中心，包括病例综合癌症中心（NCI P30 CA 043703），消化系统疾病研究核心中心（NIDDK P30 DK 097948），临床 和转化科学合作（NCATS UL 1 TR 002548），以及囊性纤维化 研究中心这种对成像研究核心的持续支持是对直接 100，000美元的机构支持，以部分抵消这种新的PET成像插件的成本。一个 咨询委员会与经验丰富的PET和MRI教师在CWRU和外部 各机构将监督该系统的组织和使用情况，并提出政策建议， 保持系统性能并最大化利用率。