Imaging Research Shared Resource

影像研究共享资源 项目总结/摘要 影像研究共享资源（Imaging SR）是Case Comprehensive Cancer的重要资产 中心（案例CCC）成员的研究，通过科学计划参与的广度和 仅去年一年，就有超过45名研究者使用了这一SR，其中54%的人 2010年，中心的7个项目中有6个项目使用了 Sr.成像SR的使命是为所有癌症研究者提供一系列全面的 临床前和临床成像能力，可提供癌症的体内和原位成像评估。的 成像SR是一个机构设施，集成了国家的最先进的和全面的成像能力， 用于癌症的动物模型，以及儿童和成人患者。实现这些努力的是成像SR的 已建立的运营和管理基础设施，包括设备齐全的临床前成像设施 现场动物房;研究专用的人类MRI扫描仪;以及研究放射化学 包括回旋加速器和多个热室的设施。成像SR的具体目标是： 1.为癌症研究者提供临床前和临床研究成像服务。 2.提供成像专业知识，设计有效的癌症成像实验。 3.提供特定项目的定量图像分析功能。 4.合成用于PET癌症研究的常规和新型放射性示踪剂。 5.培训新用户正确和安全地操作成像系统。 在上次审查中，成像SR被评为优秀至卓越。在整个供资周期 （2012-2016年），影像SR为83名注册用户提供了服务，其中48名（58%）是Case CCC 成员，代表所有7个案例CCC计划。 影像学高级代表还可以访问该部提供的全部影像学资源 凯斯西储大学（CWRU）/大学医院（UH）克利夫兰 医疗中心，包括多个临床成像扫描仪。额外的临床前成像功能 位于克利夫兰诊所（CC）的Lerner研究所（LRI），包括一个新的临床前 MRI扫描仪和多种体内生物发光和荧光扫描仪。总体而言，成像SR 为癌症研究人员提供了一个有效和具有成本效益的机会， 癌症发生和发展的途径以及新的治疗策略和方法， 早期癌症检测，最终目标是改善护理和延长癌症患者的寿命。

IMAGING RESEARCH SHARED RESOURCE PROJECT SUMMARY/ABSTRACT The Imaging Research Shared Resource (Imaging SR) is an essential asset to Case Comprehensive Cancer Center (Case CCC) members' research, illustrated by the breadth of scientific program involvement and reflected in the number of investigators who use this SR. Last year alone, over 45 investigators, 54% of whom were Case CCC members, accounting for 71% of total usage, from 6 out of the Center’s 7 Programs used the SR. The mission of the Imaging SR is to provide all cancer investigators with a comprehensive array of preclinical and clinical imaging capabilities to deliver in vivo and in situ imaging assessments of cancer. The Imaging SR is an institutional facility integrating state-of-the-art and comprehensive imaging capabilities both for animal models of cancer, as well as pediatric and adult patients. Enabling these efforts is the Imaging SR’s established operational and administrative infrastructure including a fully equipped preclinical imaging facility with onsite animal housing; a research-dedicated human MRI scanner; as well as research radiochemistry facilities including a cyclotron and multiple hot cells. The Specific Aims of the Imaging SR are to: 1. Provide preclinical and clinical research imaging services to cancer investigators. 2. Provide imaging expertise to design effective cancer imaging experiments. 3. Provide project-specific quantitative image analysis capabilities. 4. Synthesize both conventional and novel radiotracers for PET cancer studies. 5. Train new users in the proper and safe operation of the imaging systems. At last review, the Imaging SR was rated Excellent to Outstanding Merit. Throughout the current funding cycle (2012-2016), the Imaging SR provided services to 83 registered users, 48 (58%) of whom are Case CCC members, representing all 7 of the Case CCC programs. The Imaging SR also has access to the full breadth of imaging resources provided by the Department of Radiology at Case Western Reserve University (CWRU) / University Hospitals (UH) Cleveland Medical Center including multiple clinical imaging scanners. Additional preclinical imaging capabilities are housed at the Lerner Research Institute (LRI) at Cleveland Clinic (CC) including a new preclinical MRI scanner and multiple in vivo bioluminescence and fluorescence scanners. Overall, the Imaging SR presents an efficient and cost-effective opportunity for cancer investigators to comprehensively evaluate novel pathways in cancer initiation and progression as well as new therapeutic strategies and methodologies for early cancer detection with the ultimate goal of improved care and longer lives of cancer patients.