Core A: Administrative Core

核心A：行政核心

基本信息

批准号：
10188755
负责人：
Alexander Bukreyev
金额：
$ 8.06万
依托单位：
UNIVERSITY OF TEXAS MED BR GALVESTON
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-04-15 至 2026-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10188755
关键词：
Address Administrator Advisory Committees Biometry Clinical Management Collaborations Communication Containment Core Facility Coronavirus Data Decision Making Dengue Development Ebola virus Electronic Mail Ensure Evaluation Evaluation Research Experimental Designs Funding Future Genetic Transcription Goals Grant Human Resources Immune response Infection Information Dissemination Institution Intellectual Property Investigation Knowledge Laboratories Lead Leadership Marburgvirus Medical Mission Molecular National Institute of Allergy and Infectious Disease Occupational activity of managing finances Online Systems Pediatric Hospitals Policies Preparation Process Productivity Progress Reports Reporting Research Research Personnel Research Project Grants Resource Allocation Resources Scientific Evaluation Scientist Security Site Site Visit Strategic Planning Structure System Texas United States National Institutes of Health Universities Vertebrates Videoconferencing Virus Diseases Work biosafety level 4 facility experience meetings member novel strategies operation pathogenic virus product development programs synergism

项目摘要

ADMINISTRATIVE CORE (Core A): PROJECT SUMMARY/ABSTRACT The Administrative Core is responsible for the strategic planning, overall management, and coordination of the Program Project (P01) “Molecular Mechanisms of the Dysregulated Immune Response to Ebola Virus”. It provides governance, financial oversight, and operational management functions to facilitate the execution of the overall research plan, thereby enabling the Program to fulfill its mission to characterize the transcriptional, posttranscriptional, and posttranslational mechanisms following Ebola virus infection that lead to the dysregulated immune response. The Administrative Core will provide an organizational and programmatic structure to promote research productivity and synergy through scientific interactions. The Core will provide oversight in setting priorities, including decision-making processes involving the continual evaluation of research by the PIs and an advisory board. Core personnel will ensure that the Program includes biostatistical rigor and is compliant with issues involving the use of vertebrate animals, select agents, and BSL-4 facilities, and will ensure that regulatory expertise is available for future product development activities. Management activities are carried out with the advice of the External Advisory Committee in close collaboration with Core leadership. Emails, teleconferencing, and videoconferencing are maximally utilized to facilitate communication between the University of Texas Medical Branch, the lead institution for the P01, and participating institutions.

行政核心（核心A）：项目摘要/摘要行政核心负责战略规划，整体管理和协调计划项目（P01）“免疫反应对埃博拉病毒的失调的分子机制”。它提供治理，财务监督和运营管理职能，以促进执行总体研究计划，从而使该计划能够履行其使命以表征转录的特征，埃博拉病毒感染后的转录后和翻译后机制，导致免疫反应失调。行政核心将提供组织和程序化通过科学互动来促进研究生产力和协同作用的结构。核心将提供确定优先级的监督，包括决策过程，涉及对研究的持续评估由PI和顾问委员会组成。核心人员将确保该计划包括生物统计严格，并且符合涉及使用脊椎动物，精选代理和BSL-4设施的问题，并将确保可用于未来产品开发活动的监管专业知识。管理活动是在外部咨询委员会的建议下与核心领导层密切合作。电子邮件，电信和视频会议最大地用于促进沟通德克萨斯大学医学分公司，P01的主要机构和参与机构。