Purdue University Molecular Biophysics Training Program

普渡大学分子生物物理培训计划 项目总结 2015年，寨卡病毒爆发成为一场国际公共卫生危机。不到一年的时间，科学家们 在普渡大学发表了成熟寨卡病毒衣壳的结构，为免疫学家提供了药物 对如何合理开发选择性抗病毒药物有着复杂分子理解的发现专家 探员们。从发现一种新疾病到原子模型的这一惊人的快速转变 通过尖端的电子显微镜设备，对理论和应用的深入了解 生物物理学，以及由一名训练有素的博士生带头的多样化的研究团队。成功 分子生物物理学培训计划将向学员灌输许多与此相同的品质 这样的例子很有效。为此，普渡大学分子生物物理学培训项目的使命 是将来自六个不同部门的27名导师聚集在一起，培养一批优秀的毕业生 学生掌握前沿生物物理技术的基本理论和实践。该项目的负责人 目标是：(1)加强分子生物物理学在严格和 以可复制的方式解决人类健康和疾病方面的现代问题；(2)促进有效和包容性 团队合作，以及(Iii)提供根据受训人员个人目标量身定制的职业发展机会。至 达到这些目标，选定的受训人员(每年6名，通常从他们的第二年开始 学习和支持长达2年)将参加一个新的为期两学期的入门课程，将理论与团队相结合- 基于项目设计和实施，参与并帮助实施跨部门生物物理学 研讨会系列将展示学生邀请的外部演讲者和实习生在校园内的研究，并计划， 开发和实施普渡年度生物物理学研讨会，名为《搭便车指南》 生物分子星系。支持这些受训人员专业发展的关键活动的例子有 在项目课程和研讨会计划中融入团队合作的练习，积极发展和 执行详细的个人发展计划，每年审查和修订，与 导师，个性化教学和/或实习机会，针对生物物理主题量身定做的赠款撰写课程， 负责任地开展研究以及参与招聘和保留 代表不足和/或残疾学生。通过利用普渡在生物教育和自我教育方面的专业知识 评估、培训计划及其个人活动将每年进行评估和改进，以确保 该计划正在满足其目标和科学界的需求。

Purdue University Molecular Biophysics Training Program PROJECT SUMMARY In 2015, the Zika virus outbreak emerged as an international public health crisis. In less than a year, scientists at Purdue University published the structure of the mature Zika virus capsid, providing immunologists and drug discovery experts with a sophisticated molecular understanding of how to rationally develop selective anti-viral agents. This remarkably fast transition from the discovery of a novel disease to an atomic model was made possible by a cutting-edge electron microscopy facility, a deep understanding of the theory and application of biophysics, and a diverse team of researchers spearheaded by a well-trained predoctoral student. Successful molecular biophysics training programs will instill upon its trainees many of the same qualities that made this example so effective. To this end, the mission of the Purdue University Molecular Biophysics Training program is to bring together 27 preceptors from six different departments to train an outstanding cohort of graduate students in the underlying theory and practice of cutting-edge biophysical techniques. The program's chief objectives are: (i) to provide enhanced training in the application of molecular biophysics in a rigorous and reproducible way to modern problems in human health and disease, (ii) to foster effective and inclusive teamwork, and (iii) to provide career development opportunities tailored to the goals of individual trainees. To achieve these objectives, selected trainees (6 in each year of the award, typically beginning in their 2nd year of study and supported for up to 2 years) will take a new two-semester gateway class that merges theory with team- based project design and implementation, participate in and help implement an interdepartmental biophysics seminar series that will showcase student-invited external speakers and trainee research on campus, and plan, develop, and implement Purdue's annual biophysics symposium called the Hitchhiker's Guide to the Biomolecular Galaxy. Examples of key activities that support the professional development of these trainees are exercises in teamwork built into program coursework and symposium planning, active development and implementation of detailed individual development plans reviewed and revised annually in collaboration with the mentor, personalized teaching and/or internship opportunities, a grant-writing class tailored to biophysical topics, training in the responsible conduct of research, and participation in the recruitment and retention of underrepresented and/or disabled students. By leveraging Purdue's expertise in Biology Education and self- assessment, the training program and its individual activities will be evaluated annually and refined to ensure that the program is meeting its objectives and the needs of the scientific community.