Mechanisms of Disease

项目摘要/摘要 得克萨斯大学西南分校疾病机制与转化科学(MOD)研究进展 医学中心(UTSW)将为博士生提供成功参与的核心能力 翻译研究，并为他们在生物医学研究中有价值的职业做好准备。我们将每年任命 6名一年级博士生，每人为期12个月。我们将目标对准这些年轻人口，以便在他们身上打上 翻译科学思维，并提供迭代的长期积极培训，使他们能够寻求 跨学科协作。基本原理。加快生物医学基础科技成果的转化 切实改善人类健康是国家的优先事项。这一需求现在尤其紧迫，因为 当前科学和技术发现的爆炸性增长。使命：国防部将培养新型博士 转化型科学家能够针对他们的研究计划来解决未满足的治疗和 未来的诊断需求。我们的学生将准备过渡到生物医学研究 具有多种专业能力的员工队伍，并带头进行双向和跨学科的翻译 从长凳到床边和背部的各种发现，以改善人类健康。目标：打造创新型 和严谨的课程，以培养批判性思维，严谨和道德的研究设计，跨学科团队 科学，以及多样性和包容性。学生将同时具备“智力”和“实用”两方面的技能 在训练和未来的职业生涯中取得成功。节目设计：MOD是一条“补充”赛道 与现有的11个博士研究生课程重叠。我们创新严谨的课程，激烈的多元 分级指导和职业发展计划将使学生获得全面的能力 需要进行严格的翻译研究并取得成功。学生们将沉浸在独特的 在基础科学和临床科学之间研究人类疾病的机会。他们将会是 通过小组学习接触临床转化科学，在病人护理方面有组织的经验， 和沉浸在临床研究中。国防部将通过提供体验式培训来促进学生的职业发展 在团队科学方面，资助写作、领导力、创业和沟通。学生们被要求 在临床医生的第三年设计和执行“从床到床”的小型实习，并 鼓励寻求更多的实习机会，以“试驾”未来的潜在职业。此外，我们的翻译版本 正在进行的科学工作模式将汇集不同领域的临床和翻译实习生 研究人员在T0-T4翻译科学领域开展工作。这些互动将促进 交流思想，加速双向翻译。预期结果包括增加学生人数 参与翻译研究，以拨款、出版物、获得学位的时间、跨学科为衡量标准 合作和职业安置。我们的国防部计划是创新的、可持续的和具有成本效益的。MOD有一个 11年的成功历史，并将利用多种机构资源确保未来的成功。

PROJECT SUMMARY/ABSTRACT The Mechanisms of Disease and Translational Science (MoD) Track at the University of Texas Southwestern Medical Center (UTSW) will provide PhD students with core competencies needed to successfully engage in translational research and prepare them for rewarding careers in biomedical research. We will annually appoint 6 first year PhD students for 12 months each. We target this junior population to “imprint” them with the translational science mindset, and to provide iterative long term active training to enable them to seek interdisciplinary collaborations. Rationale. Accelerating the translation of basic biomedical science discoveries to tangible improvements in human health is a national priority. This need is now particularly urgent with the current explosion of scientific and technological discoveries. Mission: MoD will train a new breed of PhD translational scientists capable of targeting their research programs to address unmet therapeutic and diagnostic needs of the future. Our students will be prepared to transition into the biomedical research workforce in multiple professional capacities and to spearhead the bidirectional and interdisciplinary translation of discoveries from the “bench to bedside and back” to improve human health. Objective: Create an innovative and rigorous curriculum to foster critical thinking, rigorous and ethical research design, interdisciplinary team science, and diversity and inclusion. Students will be equipped with both the “intellectual” and “practical” skills to succeed during training and in their future careers. Program Design: MoD is a “supplemental” track overlaid on the 11 existing PhD graduate programs. Our innovative and rigorous curriculum, intense multi- tiered mentoring and career development programs will allow students to achieve a full menu of competencies required to conduct rigorous translational research and to succeed. Students will be immersed in unique opportunities to study human diseases at the interface between basic and clinical sciences. They will be exposed to clinical translational science through small group learning, structured experiences in patient care, and immersion in clinical research. MoD will foster student career development, by offering experiential training in team science, grant writing, leadership, entrepreneurship and communications. Students are required to design and execute the “bench to bedside & back” mini-internship with clinicians in their third year, and are encouraged to seek additional internships to “test-drive” potential future careers. Additionally, our translational science work-in-progress format will bring together a diverse cross-section of clinical and translational trainees and researchers operating across the T0-T4 translational science spectrum. These interactions will promote exchange of ideas and accelerate bidirectional translation. Anticipated outcomes include increasing student engagement in translational research, as measured by grants, publications, time to degree, interdisciplinary collaborations, and career placement. Our MoD plan is innovative, sustainable, and cost-effective. MoD has an eleven-year history of success, and will leverage multiple institutional resources to ensure future success.