Mechanisms of Disease

疾病机制

• 批准号: 10189651
• 负责人: HELEN L YIN
• 金额: $ 22.15万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10189651
• 关键词: Disease

PROJECT SUMMARY/ABSTRACT The Mechanisms of Disease and Translational Science (MoD) Track at the University of Texas Southwestern Medical Center (UTSW) will provide PhD students with core competencies needed to successfully engage in translational research and prepare them for rewarding careers in biomedical research. We will annually appoint 6 first year PhD students for 12 months each. We target this junior population to “imprint” them with the translational science mindset, and to provide iterative long term active training to enable them to seek interdisciplinary collaborations. Rationale. Accelerating the translation of basic biomedical science discoveries to tangible improvements in human health is a national priority. This need is now particularly urgent with the current explosion of scientific and technological discoveries. Mission: MoD will train a new breed of PhD translational scientists capable of targeting their research programs to address unmet therapeutic and diagnostic needs of the future. Our students will be prepared to transition into the biomedical research workforce in multiple professional capacities and to spearhead the bidirectional and interdisciplinary translation of discoveries from the “bench to bedside and back” to improve human health. Objective: Create an innovative and rigorous curriculum to foster critical thinking, rigorous and ethical research design, interdisciplinary team science, and diversity and inclusion. Students will be equipped with both the “intellectual” and “practical” skills to succeed during training and in their future careers. Program Design: MoD is a “supplemental” track overlaid on the 11 existing PhD graduate programs. Our innovative and rigorous curriculum, intense multi- tiered mentoring and career development programs will allow students to achieve a full menu of competencies required to conduct rigorous translational research and to succeed. Students will be immersed in unique opportunities to study human diseases at the interface between basic and clinical sciences. They will be exposed to clinical translational science through small group learning, structured experiences in patient care, and immersion in clinical research. MoD will foster student career development, by offering experiential training in team science, grant writing, leadership, entrepreneurship and communications. Students are required to design and execute the “bench to bedside & back” mini-internship with clinicians in their third year, and are encouraged to seek additional internships to “test-drive” potential future careers. Additionally, our translational science work-in-progress format will bring together a diverse cross-section of clinical and translational trainees and researchers operating across the T0-T4 translational science spectrum. These interactions will promote exchange of ideas and accelerate bidirectional translation. Anticipated outcomes include increasing student engagement in translational research, as measured by grants, publications, time to degree, interdisciplinary collaborations, and career placement. Our MoD plan is innovative, sustainable, and cost-effective. MoD has an eleven-year history of success, and will leverage multiple institutional resources to ensure future success.

项目概要/摘要 德克萨斯大学西南分校疾病机制和转化科学 (MoD) 方向 医学中心 (UTSW) 将为博士生提供成功从事相关工作所需的核心能力 转化研究，并为他们在生物医学研究领域的高回报职业做好准备。我们每年都会任命 6 名一年级博士生，每人 12 个月。我们针对这些年轻群体，让他们“铭记” 转化科学思维，并提供迭代的长期主动培训，使他们能够寻求 跨学科合作。理由。加速生物医学基础科学发现的转化 切实改善人类健康是国家优先事项。现在这一需求尤为迫切 当前科学技术发现的爆炸式增长。使命：国防部将培养新一代博士生 转化科学家能够将他们的研究计划定位于解决未得到满足的治疗和 未来的诊断需求。我们的学生将准备好过渡到生物医学研究 具有多种专业能力的员工队伍，并引领双向和跨学科翻译 从“工作台到床边再到背部”的一系列发现来改善人类健康。目标：打造创新型 严格的课程培养批判性思维、严谨和道德的研究设计、跨学科团队 科学、多样性和包容性。学生将同时具备“智力”和“实践”技能 在培训期间和未来的职业生涯中取得成功。程序设计：MoD是一个“补充”赛道 覆盖现有的 11 个博士研究生项目。我们创新而严谨的课程，激烈的多元 分层指导和职业发展计划将使学生获得全面的能力 需要进行严格的转化研究并取得成功。学生将沉浸在独特的 在基础科学和临床科学之间研究人类疾病的机会。他们将是 通过小组学习、结构化的患者护理经验接触临床转化科学， 并沉浸于临床研究。国防部将通过提供体验式培训来促进学生的职业发展 团队科学、资助写作、领导力、创业和沟通。学生必须 在第三年与临床医生一起设计并执行“从工作台到床边和背部”的迷你实习，并且是 鼓励寻求更多实习机会来“试驾”潜在的未来职业。此外，我们的翻译 正在进行的科学工作形式将汇集不同领域的临床和转化实习生 以及跨 T0-T4 转化科学领域开展工作的研究人员。这些互动将促进 交流思想并加速双向翻译。预期成果包括增加学生 参与转化研究，通过资助、出版物、获得学位的时间、跨学科来衡量 合作和职业安置。我们的国防部计划是创新的、可持续的且具有成本效益的。国防部有一个 十一年的成功历史，并将利用多种机构资源来确保未来的成功。