Structural biology and molecular biophysics training program

结构生物学和分子生物物理学培训计划

• 批准号: 10192759
• 负责人: Ben E. Black
• 金额: $ 39.01万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10192759
• 关键词: Biophysics; Molecular; Training Programs; structural biology

The central mission of our training program in Structural Biology and Molecular Biophysics (SBMB) is to leverage the immense resources, outstanding faculty, and superb graduate students of the University of Pennsylvania to promote and strengthen advanced education in structural biology and molecular biophysics. Through this training program, we seek to train a cadre of superlative students who will subsequently provide national leadership in both academia and industry in this core area of biomedical research in the United States. Our program is tailored to imbue trainees with not only deep technical training but also to provide the “soft skills” necessary to recognize and respond to the needs of the broader biomedical research effort and to do so in an efficient, productive and responsible way. Not many universities in the United States match the research resources offered by the University of Pennsylvania. Importantly, all schools of the University are located on one contiguous campus providing a significant advantage for collaborative interactions across disciplines. The University of Pennsylvania has established a broadly based research effort in structural biology and molecular biophysics, which significantly impacts the training program. In 1927 the University received an endowment to establish a foundation in medical physics, which has evolved to support a range of technologies and capabilities including structural and computational biophysics, high-resolution NMR spectroscopy, mass spectrometry, calorimetry, electron microscopy and single molecule biophysics - approaches that form the backbone of our pre-doctoral training program. It is in this strong technical framework that the training program resides. A focused group of dedicated faculty trainers provides excellent coverage of the various subfields of structural biology and molecular biophysics but is of a size that permits extensive interaction between trainees and trainers. The training program is structured around two intensive year-long series of meetings. The first will serve as a vehicle to introduce students to not only the technical aspects of SBMB but also to a range of “soft skills” and topics directly relevant to career and professional development. Open to all qualified students, this series of meetings will impact the biomedical community far beyond the trainees that are directly supported. The second series of meetings will expose trainees to more intense scientific development and aid the transition of the novice to the more independent and advanced graduate student. Emphasis will be placed on rigorous experimental design and analysis. Trainees will be drawn largely from the outstanding pool of students in the Chemistry and Biochemistry & Molecular Biophysics (BMB) graduate groups. Refined mechanisms for program oversight, mentoring and evaluation are in place. In summary, the breadth of institutional support available combined with the strength of the trainer faculty and the depth of the trainee population ensures that our record of success for recruitment and pre-doctoral training in structural biology and molecular biophysics will continue.

我们的结构生物学和分子生物物理学（SBMB）培训计划的中心使命是 利用大学的巨大资源，优秀的教师和优秀的研究生， 促进和加强结构生物学和分子生物物理学的高等教育。 通过这一培训计划，我们力求培养一批最优秀的学生，他们将随后提供 在美国生物医学研究的这一核心领域，学术界和工业界都处于国家领导地位。 我们的计划是量身定制的，不仅为学员提供深入的技术培训，而且还提供“软 技能”，以认识和应对更广泛的生物医学研究工作的需要，并这样做， 一种高效、富有成效和负责任的方式。美国没有多少大学能与这项研究相匹配 宾夕法尼亚大学提供的资源。重要的是，大学的所有学校都位于 一个连续的校园为跨学科的协作互动提供了显着的优势。的 宾夕法尼亚大学在结构生物学和分子生物学方面建立了广泛的研究工作， 生物物理学，这对培训计划产生了重大影响。1927年，该大学获得了一笔捐赠， 建立医学物理学基础，该基础已经发展到支持一系列技术和能力 包括结构和计算生物物理学，高分辨率核磁共振光谱学，质谱学， 量热法，电子显微镜和单分子生物物理学-方法，形成了我们的骨干， 博士前培训计划正是在这个强大的技术框架中，培训计划才得以实施。一 专注的教师培训师小组提供了结构的各个子领域的良好覆盖面 生物学和分子生物物理学，但其大小允许受训者之间进行广泛的互动， 教练.培训计划围绕两个为期一年的密集系列会议展开。第一个将 作为一种工具，不仅向学生介绍SBMB的技术方面，而且还介绍一系列“软 技能”和与职业和专业发展直接相关的主题。向所有合格的学生开放，这 一系列会议对生物医学界的影响将远远超出直接支助的受训人员。 第二系列会议将使受训者接触到更深入的科学发展，并帮助他们了解科学发展的趋势。 从新手到更独立、更高级的研究生的过渡。重点将放在 严格的实验设计和分析。受训人员将主要从下列优秀人才库中挑选： 化学和生物化学与分子生物物理学（BMB）研究生组的学生。成品 方案监督、指导和评价机制已经到位。总而言之， 提供机构支持，结合培训教师的力量和学员的深度 人口确保了我们在结构生物学招聘和博士前培训方面的成功记录 分子生物物理学将继续发展。