Structural biology and molecular biophysics training program

结构生物学和分子生物物理学培训计划

• 批准号: 10630348
• 负责人: Ben E. Black
• 金额: $ 40.61万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10630348
• 关键词: Biophysics; Molecular; Training Programs; structural biology

The central mission of our training program in Structural Biology and Molecular Biophysics (SBMB) is to leverage the immense resources, outstanding faculty, and superb graduate students of the University of Pennsylvania to promote and strengthen advanced education in structural biology and molecular biophysics. Through this training program, we seek to train a cadre of superlative students who will subsequently provide national leadership in both academia and industry in this core area of biomedical research in the United States. Our program is tailored to imbue trainees with not only deep technical training but also to provide the “soft skills” necessary to recognize and respond to the needs of the broader biomedical research effort and to do so in an efficient, productive and responsible way. Not many universities in the United States match the research resources offered by the University of Pennsylvania. Importantly, all schools of the University are located on one contiguous campus providing a significant advantage for collaborative interactions across disciplines. The University of Pennsylvania has established a broadly based research effort in structural biology and molecular biophysics, which significantly impacts the training program. In 1927 the University received an endowment to establish a foundation in medical physics, which has evolved to support a range of technologies and capabilities including structural and computational biophysics, high-resolution NMR spectroscopy, mass spectrometry, calorimetry, electron microscopy and single molecule biophysics - approaches that form the backbone of our pre-doctoral training program. It is in this strong technical framework that the training program resides. A focused group of dedicated faculty trainers provides excellent coverage of the various subfields of structural biology and molecular biophysics but is of a size that permits extensive interaction between trainees and trainers. The training program is structured around two intensive year-long series of meetings. The first will serve as a vehicle to introduce students to not only the technical aspects of SBMB but also to a range of “soft skills” and topics directly relevant to career and professional development. Open to all qualified students, this series of meetings will impact the biomedical community far beyond the trainees that are directly supported. The second series of meetings will expose trainees to more intense scientific development and aid the transition of the novice to the more independent and advanced graduate student. Emphasis will be placed on rigorous experimental design and analysis. Trainees will be drawn largely from the outstanding pool of students in the Chemistry and Biochemistry & Molecular Biophysics (BMB) graduate groups. Refined mechanisms for program oversight, mentoring and evaluation are in place. In summary, the breadth of institutional support available combined with the strength of the trainer faculty and the depth of the trainee population ensures that our record of success for recruitment and pre-doctoral training in structural biology and molecular biophysics will continue.

我们在结构生物学和分子生物物理学（SBMB）培训计划的中心任务是

项目成果

SAW1 is increasingly required to recruit Rad10 as SSA flap-length increases from 20 to 50 bases in single-strand annealing in S. cerevisiae.

• DOI: 10.1016/j.bbrep.2021.101125
• 发表时间: 2021-12
• 期刊: Biochemistry and biophysics reports
• 影响因子: 2.7
• 作者: Odango RJ;Camberos J;Fregoso FE;Fischhaber PL
• 通讯作者: Fischhaber PL

Technological advances in super-resolution microscopy to study cellular processes.

• DOI: 10.1016/j.molcel.2021.12.022
• 发表时间: 2022-01-20
• 期刊: Molecular cell
• 影响因子: 16
• 作者: Bond C;Santiago-Ruiz AN;Tang Q;Lakadamyali M
• 通讯作者: Lakadamyali M

A fine kinetic balance of interactions directs transcription factor hubs to genes.

相互作用的良好动力学平衡将转录因子中枢引导至基因。

• DOI: 10.1101/2024.04.16.589811
• 发表时间: 2024
• 期刊: bioRxiv : the preprint server for biology
• 作者: Mukherjee,Apratim;Fallacaro,Samantha;Ratchasanmuang,Puttachai;Zinski,Joseph;Boka,Alan;Shankta,Kareena;Mir,Mustafa
• 通讯作者: Mir,Mustafa

Developing RNA Therapeutics for TDP-43 Proteinopathy in ALS/FTD.

开发针对 ALS/FTD 中 TDP-43 蛋白病的 RNA 疗法。

• 发表时间: 2022
• 期刊: FASEB journal : official publication of the Federation of American Societies for Experimental Biology
• 作者: Copley,KatieE;Smirnov,Ashleigh;Shorter,James
• 通讯作者: Shorter,James