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Structural biology and molecular biophysics training program

Structural biology and molecular biophysics training program
结构生物学和分子生物物理学培训计划
批准号:
10630348
负责人:
Ben E. Black
金额:
$40.61万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2019
资助国家:
美国
项目状态:
已结题
起止时间:
2019-07-01 至 2024-06-30

项目摘要

项目成果

Ben E. Black的其他基金

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中文摘要
翻译
我们的结构生物学和分子生物物理学(SBMB)培训计划的中心使命是 利用大学的巨大资源,优秀的教师和优秀的研究生, 促进和加强结构生物学和分子生物物理学的高等教育。 通过这一培训计划,我们力求培养一批最优秀的学生,他们将随后提供 在美国生物医学研究的这一核心领域,学术界和工业界都处于国家领导地位。 我们的计划是量身定制的,不仅为学员提供深入的技术培训,而且还提供"软 技能",以认识和应对更广泛的生物医学研究工作的需要,并这样做, 一种高效、富有成效和负责任的方式。美国没有多少大学能与这项研究相匹配 宾夕法尼亚大学提供的资源。重要的是,大学的所有学校都位于 一个连续的校园为跨学科的协作互动提供了显着的优势。的 宾夕法尼亚大学在结构生物学和分子生物学方面建立了广泛的研究工作, 生物物理学,这对培训计划产生了重大影响。1927年,该大学获得了一笔捐赠, 建立医学物理学基础,该基础已经发展到支持一系列技术和能力 包括结构和计算生物物理学,高分辨率核磁共振光谱学,质谱学, 量热法,电子显微镜和单分子生物物理学-方法,形成了我们的骨干, 博士前培训计划培训计划正是在这个强大的技术框架中进行的。一 专注的教师培训师小组提供了结构的各个子领域的良好覆盖面 生物学和分子生物物理学,但其大小允许受训者之间进行广泛的互动, 教练.培训计划围绕两个为期一年的密集系列会议展开。第一个将 作为一种工具,不仅向学生介绍SBMB的技术方面,而且还介绍一系列"软 技能"和与职业和专业发展直接相关的主题。向所有合格的学生开放,这 一系列会议对生物医学界的影响将远远超出直接支助的受训人员。 第二系列会议将使受训者接触到更深入的科学发展,并帮助他们了解科学发展的趋势。 从新手到更独立、更高级的研究生的过渡。重点将放在 严格的实验设计和分析。受训人员将主要从下列优秀人才库中挑选: 化学和生物化学与分子生物物理学(BMB)研究生组的学生。成品 方案监督、指导和评价机制已经到位。总而言之, 提供机构支持,结合培训教师的力量和学员的深度 人口确保了我们在结构生物学招聘和博士前培训方面的成功记录 分子生物物理学将继续发展。
英文摘要
The central mission of our training program in Structural Biology and Molecular Biophysics (SBMB) is to leverage the immense resources, outstanding faculty, and superb graduate students of the University of Pennsylvania to promote and strengthen advanced education in structural biology and molecular biophysics. Through this training program, we seek to train a cadre of superlative students who will subsequently provide national leadership in both academia and industry in this core area of biomedical research in the United States. Our program is tailored to imbue trainees with not only deep technical training but also to provide the “soft skills” necessary to recognize and respond to the needs of the broader biomedical research effort and to do so in an efficient, productive and responsible way. Not many universities in the United States match the research resources offered by the University of Pennsylvania. Importantly, all schools of the University are located on one contiguous campus providing a significant advantage for collaborative interactions across disciplines. The University of Pennsylvania has established a broadly based research effort in structural biology and molecular biophysics, which significantly impacts the training program. In 1927 the University received an endowment to establish a foundation in medical physics, which has evolved to support a range of technologies and capabilities including structural and computational biophysics, high-resolution NMR spectroscopy, mass spectrometry, calorimetry, electron microscopy and single molecule biophysics - approaches that form the backbone of our pre-doctoral training program. It is in this strong technical framework that the training program resides. A focused group of dedicated faculty trainers provides excellent coverage of the various subfields of structural biology and molecular biophysics but is of a size that permits extensive interaction between trainees and trainers. The training program is structured around two intensive year-long series of meetings. The first will serve as a vehicle to introduce students to not only the technical aspects of SBMB but also to a range of “soft skills” and topics directly relevant to career and professional development. Open to all qualified students, this series of meetings will impact the biomedical community far beyond the trainees that are directly supported. The second series of meetings will expose trainees to more intense scientific development and aid the transition of the novice to the more independent and advanced graduate student. Emphasis will be placed on rigorous experimental design and analysis. Trainees will be drawn largely from the outstanding pool of students in the Chemistry and Biochemistry & Molecular Biophysics (BMB) graduate groups. Refined mechanisms for program oversight, mentoring and evaluation are in place. In summary, the breadth of institutional support available combined with the strength of the trainer faculty and the depth of the trainee population ensures that our record of success for recruitment and pre-doctoral training in structural biology and molecular biophysics will continue.
期刊论文(8)
专著(0)
科研奖励(0)
会议论文
DOI: 10.1016/j.bbrep.2021.101125
发表时间: 2021-12
期刊: Biochemistry and biophysics reports
影响因子: 2.7
作者: [Odango RJ, Camberos J, Fregoso FE, Fischhaber PL]
通讯作者: Fischhaber PL
DOI: 10.1016/j.molcel.2021.12.022
发表时间: 2022-01-20
期刊: Molecular cell
影响因子: 16
作者: [Bond C, Santiago-Ruiz AN, Tang Q, Lakadamyali M]
通讯作者: Lakadamyali M
A fine kinetic balance of interactions directs transcription factor hubs to genes.
相互作用的良好动力学平衡将转录因子中枢引导至基因。
DOI: 10.1101/2024.04.16.589811
发表时间: 2024
期刊: bioRxiv : the preprint server for biology
影响因子: --
作者: [Mukherjee,Apratim, Fallacaro,Samantha, Ratchasanmuang,Puttachai, Zinski,Joseph, Boka,Alan, Shankta,Kareena, Mir,Mustafa]
通讯作者: Mir,Mustafa
Developing RNA Therapeutics for TDP-43 Proteinopathy in ALS/FTD.
开发针对 ALS/FTD 中 TDP-43 蛋白病的 RNA 疗法。
DOI: --
发表时间: 2022
期刊: FASEB journal : official publication of the Federation of American Societies for Experimental Biology
影响因子: --
作者: [Copley,KatieE, Smirnov,Ashleigh, Shorter,James]
通讯作者: Shorter,James
Core 2: Mammalian Artificial Chromosome (MAC)
  • 批准号:
    10626286
  • 项目类别:
  • 资助金额:
    $36.48万
  • 财政年份:
    2023
  • 负责人:
    Ben E. Black
  • 依托单位:
Tuning PARP-1 retention and release on DNA breaks
  • 批准号:
    10363534
  • 项目类别:
  • 资助金额:
    $59.95万
  • 财政年份:
    2022
  • 负责人:
    Ben E. Black
  • 依托单位:
Tuning PARP-1 retention and release on DNA breaks
  • 批准号:
    10581522
  • 项目类别:
  • 资助金额:
    $55.66万
  • 财政年份:
    2022
  • 负责人:
    Ben E. Black
  • 依托单位:
Mendelian inheritance of artificial chromosomes
  • 批准号:
    10666591
  • 项目类别:
  • 资助金额:
    $116.96万
  • 财政年份:
    2021
  • 负责人:
    Ben E. Black
  • 依托单位:
国内基金
海外基金
Kidney injury molecular(KIM-1)介导肾小管上皮细胞自噬在糖尿病肾病肾间质纤维化中的作用
  • 批准号:
    81300605
  • 项目类别:
    青年科学基金项目
  • 资助金额:
    23.0万元
  • 批准年份:
    2013
  • 负责人:
    唐琳
  • 依托单位:
Molecular Plant
Molecular Interaction Reconstruction of Rheumatoid Arthritis Therapies Using Clinical Data
Molecular Plant