Metal-catalyzed transformations of unsaturated compounds

不饱和化合物的金属催化转化

• 批准号: 10198951
• 负责人: Gojko Lalic
• 金额: $ 30.48万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10198951
• 关键词: Alkenes; Alkynes; Area; Biological; Biology; Boranes; Bromine; Complex; Copper; Coupling; Development; Exhibits; Geometry; Goals; Health; Human; Hydrogen Bonding; Lead; Medicine; Metals; Methods; Mind; Modern Medicine; Modification; Organic Chemistry; Organic Synthesis; Palladium; Pharmacologic Substance; Play; Process; Property; Reaction; Research; Role; Scientist; Structure; Transition Elements; base; catalyst; cost effective; drug development; functional group; novel; pi bond; tool

Project summary Organic molecules play an important role in a number of research areas relevant to human health, including biology, medicine, and drug development. One of the goals of synthetic organic chemistry is to facilitate discovery in these fields by providing access to organic molecules of increasing complexity and variety, and by expanding our ability to efficiently manipulate their structure and their properties. A critical part of the efforts toward this goal is the development of new organic transformations. The goal of the research described in this proposal is the development of two new classes of reactions: 1) anti-selective hydroalkylation of terminal alkynes. 2) Differential dihydrofunctionalization of alkynes. Once successfully developed, these transformations will greatly increase the complexity and versatility of products that can be obtained directly from alkynes. Considering the importance of alkynes as reactive intermediate in organic chemistry, this will have significant impact on the synthesis of biologically relevant compounds.

项目总结