Poor sense of smell and the health of older adults
嗅觉差与老年人的健康
基本信息
- 批准号:10363796
- 负责人:
- 金额:$ 57.93万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-06-15 至 2027-02-28
- 项目状态:未结题
- 来源:
- 关键词:AccelerationAdultAffectAfrican American populationAgeAgingAlzheimer&aposs DiseaseAtherosclerosis Risk in CommunitiesBehaviorBlack PopulationsBody CompositionBody Weight decreasedChronicChronic DiseaseChronologyClinicalClinical ManagementCognitiveCollaborationsCollectionCommunitiesDataData CollectionDementiaDetectionDiabetes MellitusDiet and NutritionDiseaseElderlyEpidemiologistExcess MortalityExhibitsHealthImpairmentIndividualIntervention TrialKnowledgeLifeLinkLongevityLungMonitorMoodsNeurocognitiveNeurodegenerative DisordersOlfactory dysfunctionOutcomeParkinson DiseaseParkinson&aposs DementiaParticipantPerformancePhysiologicalPneumoniaPopulationPopulations at RiskPredispositionPrevalenceProspective StudiesPsyche structurePublic HealthPublishingQuality of lifeRaceReproducibilityResearchResearch DesignResearch PersonnelRespiratory DiseaseRiskSafetySample SizeSensorySmell PerceptionSolidSourceStatistical Data InterpretationSymptomsSystemTestingVisitWomanbasebiracialcardiovascular disorder riskclinically significantcognitive functioncohortcomorbidityepigenetic markerexperiencefrailtyfunctional declinehealth datahuman old age (65+)improvedinnovationmenmental functionmortalitymultidisciplinarynovelnutritionprospectivepublic health relevancesexstressorvalidation studies
项目摘要
PROJECT SUMMARY/ABSTRACT
Up to a quarter of older US adults have a poor sense of smell, a sensory impairment which most are unaware
of. We and others found that poor olfaction is an important early symptom of dementia and Parkinson’s disease
(PD), and robustly predicts accelerated mortality. Others also speculate that poor olfaction adversely affects
nutrition, safety, and quality of life, but rigorous empirical data are largely lacking. Our most recent analysis
revealed that dementia, PD, and weight loss combined explained only ~30% of poor olfaction-associated excess
mortality in older adults, leaving a large portion of the potential causes of such increased mortality still unknown.
The proposed project thus aims to leverage the predictive and informational power available via inexpensive,
facile, and noninvasive olfaction testing, by answering two novel and clinically-significant questions: 1) What
adverse health outcomes can a poor sense of smell in older adults potentially herald, in addition to
neurodegenerative diseases? 2) Is poor olfaction a marker of accelerated aging? We will exploit extensive
prospective data from the Health ABC and ARIC-Neurocognitive studies – well-established community-based
biracial cohorts with comparable populations, study design, and data collection. To our knowledge, the proposed
study will be the largest to date, combining the objectively-tested sense of smell and longitudinally assessed
health outcomes in 8,630 US adults aged ≥65 years, including 56.6% women and 27.6% African Americans to
assess sex and racial influences. We hypothesize that, as an early marker and/or contributor, poor olfaction in
older adults signifies elevated risk of multiple major diseases, including but not limited to dementia and PD (Aim
1), declines in physical, pulmonary, and cognitive/mental functions, and frailty (Aim 2), and it is associated with
epigenetic markers of age acceleration (Aim 3). Based on our preliminary findings, we further hypothesize that
sex and race may modify the relationships of dementia, PD, and other adverse health outcomes associated with
a poor sense of smell. The aims are supported by our rigorous published and unpublished preliminary data, and
a multidisciplinary team of epidemiologists, biostatisticians, and clinical researchers with a proven track record
of productive collaborations. Scientific rigor is assured by large sample sizes, meticulously collected health data,
carefully planned statistical analyses, cross-validation of study findings, strategized pooled analyses, and a very
experienced multi-institutional research team. Our innovative proposed analyses and predicted results will
significantly advance understanding of what poor olfaction means for the health of older adults, besides dementia
and PD, and may thus help shift the geriatric clinical paradigm toward assessing olfaction in the elderly during
clinical visits, to monitor and better anticipate risks of impending conditions, to inform the identification of at-risk
populations for novel interventional trials, and ultimately to improve the health and survival of older adults.
项目总结/文摘
项目成果
期刊论文数量(0)
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HONGLEI CHEN其他文献
HONGLEI CHEN的其他文献
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{{ truncateString('HONGLEI CHEN', 18)}}的其他基金
Poor sense of smell and the health of older adults
嗅觉差与老年人的健康
- 批准号:
10633069 - 财政年份:2022
- 资助金额:
$ 57.93万 - 项目类别:
Pesticides, Olfaction, and Neurodegeneration Among US Farmers
美国农民的农药、嗅觉和神经退行性疾病
- 批准号:
10565881 - 财政年份:2019
- 资助金额:
$ 57.93万 - 项目类别:
Pesticides, Olfaction, and Neurodegeneration Among US Farmers
美国农民的农药、嗅觉和神经退行性疾病
- 批准号:
10331301 - 财政年份:2019
- 资助金额:
$ 57.93万 - 项目类别:
Diet, gene-diet interactions and risk of Parkinson's
饮食、基因-饮食相互作用和帕金森病风险
- 批准号:
6768951 - 财政年份:2004
- 资助金额:
$ 57.93万 - 项目类别:
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