Poor sense of smell and the health of older adults

嗅觉差与老年人的健康

• 批准号: 10363796
• 负责人: HONGLEI CHEN
• 金额: $ 57.93万
• 依托单位: MICHIGAN STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-15 至 2027-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10363796
• 关键词: Acceleration; Adult; Affect; African American population; Age; Aging; Alzheimer' s Disease; Atherosclerosis Risk in Communities; Behavior; Black Populations; Body Composition; Body Weight decreased; Chronic; Chronic Disease; Chronology; Clinical; Clinical Management; Cognitive; Collaborations; Collection; Communities; Data; Data Collection; Dementia; Detection; Diabetes Mellitus; Diet and Nutrition; Disease; Elderly; Epidemiologist; Excess Mortality; Exhibits; Health; Impairment; Individual; Intervention Trial; Knowledge; Life; Link; Longevity; Lung; Monitor; Moods; Neurocognitive; Neurodegenerative Disorders; Olfactory dysfunction; Outcome; Parkinson Disease; Parkinson' s Dementia; Participant; Performance; Physiological; Pneumonia; Population; Populations at Risk; Predisposition; Prevalence; Prospective Studies; Psyche structure; Public Health; Publishing; Quality of life; Race; Reproducibility; Research; Research Design; Research Personnel; Respiratory Disease; Risk; Safety; Sample Size; Sensory; Smell Perception; Solid; Source; Statistical Data Interpretation; Symptoms; System; Testing; Visit; Woman; base; biracial; cardiovascular disorder risk; clinically significant; cognitive function; cohort; comorbidity; epigenetic marker; experience; frailty; functional decline; health data; human old age (65+); improved; innovation; men; mental function; mortality; multidisciplinary; novel; nutrition; prospective; public health relevance; sex; stressor; validation studies

PROJECT SUMMARY/ABSTRACT Up to a quarter of older US adults have a poor sense of smell, a sensory impairment which most are unaware of. We and others found that poor olfaction is an important early symptom of dementia and Parkinson’s disease (PD), and robustly predicts accelerated mortality. Others also speculate that poor olfaction adversely affects nutrition, safety, and quality of life, but rigorous empirical data are largely lacking. Our most recent analysis revealed that dementia, PD, and weight loss combined explained only ~30% of poor olfaction-associated excess mortality in older adults, leaving a large portion of the potential causes of such increased mortality still unknown. The proposed project thus aims to leverage the predictive and informational power available via inexpensive, facile, and noninvasive olfaction testing, by answering two novel and clinically-significant questions: 1) What adverse health outcomes can a poor sense of smell in older adults potentially herald, in addition to neurodegenerative diseases? 2) Is poor olfaction a marker of accelerated aging? We will exploit extensive prospective data from the Health ABC and ARIC-Neurocognitive studies – well-established community-based biracial cohorts with comparable populations, study design, and data collection. To our knowledge, the proposed study will be the largest to date, combining the objectively-tested sense of smell and longitudinally assessed health outcomes in 8,630 US adults aged ≥65 years, including 56.6% women and 27.6% African Americans to assess sex and racial influences. We hypothesize that, as an early marker and/or contributor, poor olfaction in older adults signifies elevated risk of multiple major diseases, including but not limited to dementia and PD (Aim 1), declines in physical, pulmonary, and cognitive/mental functions, and frailty (Aim 2), and it is associated with epigenetic markers of age acceleration (Aim 3). Based on our preliminary findings, we further hypothesize that sex and race may modify the relationships of dementia, PD, and other adverse health outcomes associated with a poor sense of smell. The aims are supported by our rigorous published and unpublished preliminary data, and a multidisciplinary team of epidemiologists, biostatisticians, and clinical researchers with a proven track record of productive collaborations. Scientific rigor is assured by large sample sizes, meticulously collected health data, carefully planned statistical analyses, cross-validation of study findings, strategized pooled analyses, and a very experienced multi-institutional research team. Our innovative proposed analyses and predicted results will significantly advance understanding of what poor olfaction means for the health of older adults, besides dementia and PD, and may thus help shift the geriatric clinical paradigm toward assessing olfaction in the elderly during clinical visits, to monitor and better anticipate risks of impending conditions, to inform the identification of at-risk populations for novel interventional trials, and ultimately to improve the health and survival of older adults.

项目总结/文摘