Post-Vent, the Sequelae: Personalized Prognostic Modeling for Consequences of Neonatal Intermittent Hypoxemia in Preterm Infants at Pre-School Age

排气后的后遗症：学龄前早产儿新生儿间歇性低氧血症后果的个性化预后模型

• 批准号: 10363406
• 负责人: Namasivayam Ambalavanan
• 金额: $ 148.56万
• 依托单位: LURIE CHILDREN'S HOSPITAL OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-12-15 至 2026-11-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10363406
• 关键词: Age; Age-Months; Asthma; Breathing; Bronchopulmonary Dysplasia; Caffeine; Characteristics; Child; Child Care; Childhood; Clinical; Clinical Data; Clinical Treatment; Cognitive; Collaborations; Consent; Data; Development; Diagnosis; Discipline of Nursing; Disease; Early Diagnosis; Early Intervention; Early identification; Emotional; Enrollment; Event; Frequencies; Funding; Future; Goals; Health; Hypoxemia; Impairment; Infant; Infrastructure; Intervention; Intervention Trial; Investigation; Knowledge; Life; Link; Measures; Motor; National Heart, Lung, and Blood Institute; Neonatal; Neonatal Intensive Care; Neonatal Intensive Care Units; Nervous System Physiology; Neurodevelopmental Impairment; Nursery Schools; Outcome; Oxygen; Pathologic; Pathway interactions; Patients; Pattern; Persons; Pharmaceutical Preparations; Physiological; Play; Population; Pregnancy; Premature Birth; Premature Infant; Prevalence; Prevention strategy; Preventive; Prognosis; Prospective Studies; Protocols documentation; Records; Research; Research Personnel; Resolution; Resources; Respiratory physiology; Risk; Role; Sensory; Sleep; Sleep Apnea Syndromes; Structure; Therapeutic; Time; Training; United States National Institutes of Health; Vent; Weaning; Work; advanced analytics; airway hyperresponsiveness; asthma model; base; clinical care; clinical phenotype; cohort; cost; early screening; empowered; experience; improved; infancy; innovation; negative affect; neonatal care; novel therapeutics; peer; postnatal; premature; prognostic; prognostic model; programs; rehabilitation service; respiratory; response; standard of care; supplemental oxygen; targeted treatment

Project Summary / Abstract This is the application from collaborators of the Prematurity-Related Ventilatory Control (Pre-Vent): Role in Respiratory Outcomes NHLBI Collaborative Program. Central to this proposal is a prospective study entitled “Post-Vent, the Sequelae: Personalized Prognostic Modeling for Consequences of Neonatal Intermittent Hypoxemia in Preterm Infants at Pre-school Age”. This multicenter proposal innovatively combines detailed clinical phenotyping with advanced analytics of longitudinal recordings of intermittent hypoxemia (IH) events to develop personalized prognostic models of long-term outcomes that could transform clinical care by allowing for timely identification of at-risk infants and specific pathologic IH patterns for future trials of targeted intervention. Extremely premature birth and various postnatal factors can negatively affect outcome. In a significant proportion of extremely premature infants the sequelae persist beyond infancy with relatively high rates of asthma and sleep disordered breathing (SDB) in childhood and worrisome prevalence of neurodevelopmental impairment (NDI). This multicenter proposal will systematically and innovatively examine the interaction between IH during neonatal intensive care and these sequelae by means of detailed clinical phenotyping and advanced analytics. The proposed investigation will provide personalized prognosis and identification of infants at risk of poor long-term outcome that could transform clinical care and uncover targets for preventive or therapeutic strategies. The main goal of this proposal is to build prognostic models of asthma, SDB, and NDI at pre-school age in former extremely premature infants based on physiologic waveforms and clinical characteristics in the neonatal intensive care unit. To achieve this goal this time-sensitive proposal leverages the population, research structure and expertise, and analytic resources developed for the NHLBI-funded Pre-Vent collaboration.

项目摘要/摘要