STOP BPD

停止BPD

基本信息

项目摘要

 DESCRIPTION (provided by applicant): Bronchopulmonary dysplasia (BPD) is a common morbidity in extremely low birth weight (ELBW) infants. Our research group has considerable expertise in translational research on BPD. We have: (a) developed models using only limited clinical information to predict BPD or death by postnatal age or respiratory illness severity in ELBW infants, (b) prospectively evaluated pulmonary hypertension in BPD and (c) identified biomarkers associated with BPD/death in a cohort of 1067 ELBW infants using multiple clinical variables and 25 cytokines in blood. More recently, we have made novel observations on the genetic basis of BPD by genome-wide analysis in 751 ELBW infants. In additional ongoing studies, we have identified novel proteomic biomarkers of BPD, and have determined alterations in the airway microbiome in BPD. The overall objective of "STOP BPD" (Signature of Top Omic Profiles in BPD) is to prospectively define and validate clinical and "omic" signatures associated with resilience against, or risk for development of BPD. To address this objective, we will build upon our recent studies on genomics, proteomics, respiratory microbiome, and model development in BPD. We will evaluate a prospective cohort (Generic Database or GDB cohort of the NICHD Neonatal Research Network) of 300 preterm infants <29 weeks gestation born in 2015-2017 (n=213 in 2013 alone, with 80%+ enrollment) by the following Specific Aims: Specific Aim 1- Development and validation of a personalized genomic risk/resilience score for BPD and severe BPD using a combination of genome-wide expression analysis and targeted SNP profiling in blood collected within 72h of birth Specific Aim 2 - (a) Development and validation of a personalized urinary proteomic risk/resilience score for BPD and severe BPD measured in the first postnatal week (b) Development and validation of a personalized plasma proteomic and cytokine risk/resilience score for BPD and severe BPD measured within 72h of birth Specific Aim 3 - Development and validation of a personalized airway microbiome risk/resilience score for BPD and severe BPD using tracheal aspirates collected in the first postnatal week Specific Aim 4 - Development of a combined "Omic" scoring system combining the genomic, proteomic, and microbiomic scores with the clinical model We will develop and determine the accuracy of the various models in the Development cohort (n=150), and validate them in the Validation cohort (n=150). These novel models can be used to define the target population for future interventions, assess efficacy of specific interventions, develop a "lab on chip", and support future studies on the biology of BPD.
 描述(由申请人提供):支气管肺发育不良(BPD)是极低出生体重(ELBW)婴儿的常见病症。我们的研究小组在 BPD 转化研究方面拥有丰富的专业知识。我们已经:(a)仅使用有限的临床信息开发了模型,根据 ELBW 婴儿的出生后年龄或呼吸系统疾病严重程度来预测 BPD 或死亡,(b)前瞻性评估 BPD 中的肺动脉高压,以及(c)使用多种临床变量和血液中的 25 种细胞因子,在 1067 名 ELBW 婴儿的队列中确定了与 BPD/死亡相关的生物标志物。最近,我们通过对 751 名 ELBW 婴儿进行全基因组分析,对 BPD 的遗传基础进行了新的观察。在其他正在进行的研究中,我们已经确定了 BPD 的新型蛋白质组生物标志物,并确定了 BPD 中气道微生物组的变化。 “STOP BPD”(BPD 中顶级组学特征的签名)的总体目标是前瞻性地定义和验证与 BPD 的恢复力或发展风险相关的临床和“组学”签名。为了实现这一目标,我们将基于最近在基因组学、蛋白质组学、呼吸道微生物组和 BPD 模型开发方面的研究。我们将通过以下具体目标评估前瞻性队列(NICHD 新生儿研究网络的通用数据库或 GDB 队列),该队列由 2015 年至 2017 年出生的 300 名妊娠 <29 周的早产儿组成(仅 2013 年就有 213 名,入组率超过 80%): 具体目标 1-结合使用以下方法,开发和验证 BPD 和严重 BPD 的个性化基因组风险/弹性评分 对出生后 72 小时内采集的血液进行全基因组表达分析和靶向 SNP 分析 具体目标 2 - (a) 开发和验证 出生后第一周测量的 BPD 和严重 BPD 的个性化尿蛋白质组风险/弹性评分 (b) 开发和验证出生 72 小时内测量的 BPD 和严重 BPD 的个性化血浆蛋白质组和细胞因子风险/弹性评分 具体目标 3 - 使用气管开发和验证 BPD 和严重 BPD 的个性化气道微生物组风险/弹性评分 具体目标 4 - 开发将基因组、蛋白质组和微生物组评分与临床模型相结合的组合“Omic”评分系统 我们将开发并确定开发队列 (n=150) 中各种模型的准确性,并在验证队列 (n=150) 中对其进行验证。这些新颖的模型可用于定义未来干预措施的目标人群、评估特定干预措施的功效、开发“芯片实验室”并支持未来 BPD 生物学研究。

项目成果

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科研奖励数量(0)
会议论文数量(0)
专利数量(2)

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Namasivayam Ambalavanan其他文献

Namasivayam Ambalavanan的其他文献

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{{ truncateString('Namasivayam Ambalavanan', 18)}}的其他基金

Let-7b in BPD
BPD 中的 Let-7b
  • 批准号:
    10655734
  • 财政年份:
    2023
  • 资助金额:
    $ 36.75万
  • 项目类别:
Prapela® SVS incubator pad: A cost-effective stochastic vibrotactile device to improve the clinical course of infants with apnea of prematurity.
Prapela® SVS 保温箱垫:一种经济高效的随机振动触觉设备,可改善早产儿呼吸暂停婴儿的临床病程。
  • 批准号:
    10576754
  • 财政年份:
    2023
  • 资助金额:
    $ 36.75万
  • 项目类别:
Vital Signs In Opioid-Exposed Neonates
暴露于阿片类药物的新生儿的生命体征
  • 批准号:
    10493363
  • 财政年份:
    2021
  • 资助金额:
    $ 36.75万
  • 项目类别:
UAB Clinical Site HEAL Neonatal Opioid Withdrawal Pharmacological Treatments
UAB 临床站点 HEAL 新生儿阿片类药物戒断药物治疗
  • 批准号:
    10891299
  • 财政年份:
    2021
  • 资助金额:
    $ 36.75万
  • 项目类别:
Post-Vent, the Sequelae: Personalized Prognostic Modeling for Consequences of Neonatal Intermittent Hypoxemia in Preterm Infants at Pre-School Age
排气后的后遗症:学龄前早产儿新生儿间歇性低氧血症后果的个性化预后模型
  • 批准号:
    10363406
  • 财政年份:
    2021
  • 资助金额:
    $ 36.75万
  • 项目类别:
UAB Clinical Site HEAL Neonatal Opioid Withdrawal Pharmacological Treatments
UAB 临床站点 HEAL 新生儿阿片类药物戒断药物治疗
  • 批准号:
    10372486
  • 财政年份:
    2021
  • 资助金额:
    $ 36.75万
  • 项目类别:
Vital Signs In Opioid-Exposed Neonates
暴露于阿片类药物的新生儿的生命体征
  • 批准号:
    10360908
  • 财政年份:
    2021
  • 资助金额:
    $ 36.75万
  • 项目类别:
Post-Vent, the Sequelae: Personalized Prognostic Modeling for Consequences of Neonatal Intermittent Hypoxemia in Preterm Infants at Pre-School Age
排气后的后遗症:学龄前早产儿新生儿间歇性低氧血症后果的个性化预后模型
  • 批准号:
    10541156
  • 财政年份:
    2021
  • 资助金额:
    $ 36.75万
  • 项目类别:
Acute Renal Injury Sequelae in NICU Graduates (ARISING)
NICU 毕业生的急性肾损伤后遗症 (ARISING)
  • 批准号:
    9899244
  • 财政年份:
    2019
  • 资助金额:
    $ 36.75万
  • 项目类别:
Pre-Vent Apnea
预防呼吸暂停
  • 批准号:
    10006023
  • 财政年份:
    2016
  • 资助金额:
    $ 36.75万
  • 项目类别:

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