Post-Vent, the Sequelae: Personalized Prognostic Modeling for Consequences of Neonatal Intermittent Hypoxemia in Preterm Infants at Pre-School Age

项目摘要/摘要 这是早产相关呼吸控制(PREVENT)合作者的应用： 呼吸结果NHLBI合作计划。这项建议的核心是一项前瞻性研究，题为 《后遗症：新生儿间歇性后果的个性化预测模型》 学龄前早产儿的低氧血症“。该多中心方案创新性地结合了详细的 间歇性低氧血症(IH)事件纵向记录的临床表型和高级分析 开发个性化的长期结果预测模型，通过允许 及时识别高危婴儿和特定的病理IH模式，为将来的靶向干预试验做准备。 极早产和各种出生后因素会对结局产生负面影响。在相当大的比例中 极早产儿的后遗症持续到婴儿期以后，哮喘和睡眠的发生率相对较高。 儿童时期的呼吸紊乱(SDB)和令人担忧的神经发育障碍(NDI)的流行。 这一多中心方案将系统地和创新性地研究新生儿期间IH之间的相互作用 重症监护和这些后遗症通过详细的临床表型和先进的分析手段。这个 拟议的调查将提供个性化的预后和对长期处于不良风险的婴儿的识别 可能改变临床护理并发现预防或治疗策略的目标的结果。 这项建议的主要目标是建立哮喘、SDB和NDI在学龄前儿童中的预后模型 极早产儿的生理波形与新生儿临床特征 重症监护室。为了实现这一目标，这项时间敏感的提案利用了人口、研究结构 和专业知识，以及为NHLBI资助的事件前合作开发的分析资源。

Project Summary / Abstract This is the application from collaborators of the Prematurity-Related Ventilatory Control (Pre-Vent): Role in Respiratory Outcomes NHLBI Collaborative Program. Central to this proposal is a prospective study entitled “Post-Vent, the Sequelae: Personalized Prognostic Modeling for Consequences of Neonatal Intermittent Hypoxemia in Preterm Infants at Pre-school Age”. This multicenter proposal innovatively combines detailed clinical phenotyping with advanced analytics of longitudinal recordings of intermittent hypoxemia (IH) events to develop personalized prognostic models of long-term outcomes that could transform clinical care by allowing for timely identification of at-risk infants and specific pathologic IH patterns for future trials of targeted intervention. Extremely premature birth and various postnatal factors can negatively affect outcome. In a significant proportion of extremely premature infants the sequelae persist beyond infancy with relatively high rates of asthma and sleep disordered breathing (SDB) in childhood and worrisome prevalence of neurodevelopmental impairment (NDI). This multicenter proposal will systematically and innovatively examine the interaction between IH during neonatal intensive care and these sequelae by means of detailed clinical phenotyping and advanced analytics. The proposed investigation will provide personalized prognosis and identification of infants at risk of poor long-term outcome that could transform clinical care and uncover targets for preventive or therapeutic strategies. The main goal of this proposal is to build prognostic models of asthma, SDB, and NDI at pre-school age in former extremely premature infants based on physiologic waveforms and clinical characteristics in the neonatal intensive care unit. To achieve this goal this time-sensitive proposal leverages the population, research structure and expertise, and analytic resources developed for the NHLBI-funded Pre-Vent collaboration.