Core A: Administrative Core

行政核心（核心A）在目前的赠款期间履行了三大职能， 并将继续这样做，在这一更新。一个功能是P01的整体管理， 这是PI Steven Balk与管理员的责任，并与 其他的私家侦探这包括解决所有行政问题，组织小组会议， 组织内部和外部审查，并在一般情况下促进沟通， 合作。核心小组的第二项职能是协助项目努力， 确保他们的实验室研究和发现具有生理学意义，并最终 将他们的发现应用到病人身上与我们的密切互动促进了这一点。 临床医生，由我们的内部顾问委员会代表。通过既往/正在进行的临床试验 和组织库的工作，这些临床研究者 收集（并继续收集）有价值的样本，从病人在不同阶段的， 疾病和不同的治疗后。在与项目负责人的讨论中，他们提供了 相关临床样本进行分析，并提供了进一步了解潜在的生物学 实验室检查结果的重要性。第三个核心职能是为以下方面提供统计支持： 每个项目负责人在他们的实验设计。具体目标是：（1）提供 行政支持，以确保项目目标的实现，2）协助 将每个项目的结果转化为临床，3）为每个项目提供生物统计支持 项目

The Administrative Core (Core A) has fulfilled three major functions during the current grant, and will continue to do so in this renewal. One function is the overall management of the P01, which is the responsibility of the PI, Steven Balk, with an administrator and in consultation with the other PIs. This includes addressing all administrative issues, organizing group meetings, organizing internal and external reviews, and in general facilitating communications and collaborations. The second function of the Core has been to assist the Projects in efforts to ensure that their laboratory studies and findings are physiologically significant, and ultimately to translate their findings into patients. This has been facilitated by close interactions with our clinicians, represented by our internal advisory board. Through previous/ongoing clinical trials and tissue banking efforts at their respective institutions, these clinical investigators have collected (and continue to collect) valuable samples from patients at varying stages of their disease and after varying therapies. In discussions with the Project Leaders, they have provided relevant clinical samples for analysis and have provided further insight into potential biological significance of laboratory findings. The third Core function is to provide statistical support for each of the Project Leaders in their experimental designs. The Specific Aims are 1) Provide administrative support to insure that the goals of the project are achieved, 2) Assist in translating the results from each Project into the clinic, 3) Provide biostatistical support for each Project.