Core A: Administrative Core

行政核心(核心A)在本次赠款期间履行了三项主要职能， 并将在这次更新中继续这样做。一个功能是对P01进行全面管理， 这是私家侦探史蒂文·巴尔克的责任，他与管理员一起，并与 其他的私家侦探。这包括解决所有行政问题，组织小组会议， 组织内部和外部审查，并总体上促进沟通和 合作。核心的第二个职能是协助项目努力 确保他们的实验室研究和发现具有生理意义，并最终 将他们的发现转化为患者。这是通过与我们的 临床医生，由我们的内部顾问委员会代表。通过先前/正在进行的临床试验 和组织库的努力，这些临床研究人员已经 从患者的不同阶段收集(并继续收集)有价值的样本 在不同的治疗方法之后。在与项目负责人的讨论中，他们提供了 相关的临床样本用于分析，并提供了对潜在生物学的进一步洞察 实验室发现的意义。第三个核心功能是提供统计支持 每个项目负责人在他们的实验设计中。具体目标是：1)提供 行政支持，以确保项目目标的实现，2)协助 将每个项目的结果转化为临床，3)为每个项目提供生物统计学支持 项目。

The Administrative Core (Core A) has fulfilled three major functions during the current grant, and will continue to do so in this renewal. One function is the overall management of the P01, which is the responsibility of the PI, Steven Balk, with an administrator and in consultation with the other PIs. This includes addressing all administrative issues, organizing group meetings, organizing internal and external reviews, and in general facilitating communications and collaborations. The second function of the Core has been to assist the Projects in efforts to ensure that their laboratory studies and findings are physiologically significant, and ultimately to translate their findings into patients. This has been facilitated by close interactions with our clinicians, represented by our internal advisory board. Through previous/ongoing clinical trials and tissue banking efforts at their respective institutions, these clinical investigators have collected (and continue to collect) valuable samples from patients at varying stages of their disease and after varying therapies. In discussions with the Project Leaders, they have provided relevant clinical samples for analysis and have provided further insight into potential biological significance of laboratory findings. The third Core function is to provide statistical support for each of the Project Leaders in their experimental designs. The Specific Aims are 1) Provide administrative support to insure that the goals of the project are achieved, 2) Assist in translating the results from each Project into the clinic, 3) Provide biostatistical support for each Project.