Evaluation of novel markers of exposure and biological response to 1,4-dioxane
1,4-二恶烷暴露和生物反应的新型标记物的评估
基本信息
- 批准号:10361887
- 负责人:
- 金额:$ 40.14万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-09-07 至 2027-06-30
- 项目状态:未结题
- 来源:
- 关键词:AddressAdultAffectAnimalsAreaAwarenessBiologicalBiological AssayBiological MarkersBiological MonitoringBloodBlood specimenCarcinogensChemicalsClinicalCommunicationCommunitiesCountyCross-Sectional StudiesDataData AnalysesDioxanesDiseaseEnvironmentEthylene DichloridesEvaluationExposure toFrightGoalsGuidelinesHazardous SubstancesHealthHepatocarcinogenesisHepatotoxicityHigh PrevalenceHomeHumanIndividualIndustrializationLinkLipidsLiteratureLiverLong IslandMass Spectrum AnalysisMeasuresMunicipalitiesNew YorkNorth CarolinaParticipantPolicy MakerPopulationQuestionnairesResearchResearch PersonnelRiskRiversSamplingSerumSiteSolventsSourceSuperfundSurfaceSystemTechniquesTest ResultTimeTranslational ResearchTrichloroethanesTrichloroethyleneUnited StatesUnited States Environmental Protection AgencyVariantWaterWater PollutantsWater Supplybasecancer riskcandidate selectioncohortcommunity engagementcontaminated drinking waterdata managementdrinking waterexposed human populationground waterhealth datainsightmetabolomemetabolomicsnew technologynovel markernovel strategiespersonal care productspollutantprogramspublic drinkingremediationresponsesensorsuperfund sitetoolvolatile organic compoundwater samplingwater sampling/testingwater testing
项目摘要
Project Summary/Abstract
1,4-Dioxane (1,4-DX) is a synthetic chemical historically used as a stabilizer of chlorinated solvents and
currently used in a range of consumer and personal care products. Over one-fifth of the US public drinking
water supply contains detectable levels of 1,4-DX, and approximately 7% of drinking water samples tested
exceed the federal cancer risk level of 0.35 μg/L. Widespread contamination of drinking water has been
observed in groundwater in Nassau and Suffolk Counties of Long Island, New York, where 75% of population
have water sources with 1,4-DX concentrations exceeding 0.35 μg/L. Furthermore, standard municipal
treatment systems are ineffective at removing 1,4-DX, enabling its persistence in drinking water supplies. The
US Environmental Protection Agency (EPA) has designated 1,4-DX as a “high priority” chemical and classified
it as a probable human carcinogen based on evidence from experimental animal studies, primarily based on
effects on the liver. Despite the high prevalence in the environment and potential human health risks, there is a
paucity of human exposure and health data. We will apply novel approaches to evaluate exposure to 1,4-DX
and co-occurring contaminants (such as the volatile organic compounds 1,1-dichloroethane (DCA),
trichloroethylene (TCE), and 1,1,1-trichloroethane (TCA)) in two communities: Long Island, New York (our
primary study area) and Cape Fear River Watershed, North Carolina (secondary study area). We will use our
newly developed, highly sensitive mass spectrometry-based assay for assessment of exposure to 1,4-DX in
water and blood samples. In addition, we will evaluate associations between exposure to 1,4-DX and co-
contaminants and levels of endogenous metabolites and lipids in blood using both untargeted and targeted
metabolomics. The use of biomonitoring and metabolomics provide powerful tools to assess early exposures
and biological changes in the years preceding clinical manifestation of disease. We propose a cross-sectional
study on Long Island (an area with many Superfund sites potentially contributing to contamination of drinking
water with 1,4-DX) to i) assess human exposure to 1,4-DX and evaluate the relationship between
environmental and biological exposure indicators, ii) evaluate temporal variability of exposure to 1,4-DX and
metabolite levels by comparing data from two different US regions with different water sources (ground water
in NY and surface water in NC), and iii) evaluate the relationship between 1,4-DX exposure and metabolites of
biological responses particularly for liver toxicity and carcinogenesis. This project will greatly enhance our
understanding of the extent of exposure to 1,4-DX (and its co-occurring contaminants) in drinking water and
the potential for human health effects. The results will provide scientific evidence for policy makers to set
guidelines for concentration standards for 1,4-DX and provide researchers in the Superfund Research Program
with new tools to detect hazardous substances in the environment as well as novel technologies for
remediation.
项目总结/文摘
项目成果
期刊论文数量(0)
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科研奖励数量(0)
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Nicole Deziel其他文献
Nicole Deziel的其他文献
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{{ truncateString('Nicole Deziel', 18)}}的其他基金
Evaluation of novel markers of exposure and biological response to 1,4-dioxane
1,4-二恶烷暴露和生物反应的新型标记物的评估
- 批准号:
10698011 - 财政年份:2022
- 资助金额:
$ 40.14万 - 项目类别:
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